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In the present text, it is exposed about the physical and mental health problems generated by the leadership style in Mexico with respect to work based on an analysis of the National Institute of Public Health and the World Health Organization, as well as a theoretical reflection. and empirical research on its possible causes and an analysis of a speech on the national and international implications of the phenomenon that has been called the great resignation and the silent resignation. Above all, the typology between the relationship that exists between the type of toxic leadership, both in its causes, theoretical, and explanatory models, as well as in the consequences and dynamic relationships of the organizational system and the implications in economic matters, and in the health of workers for the formulation and analysis of public policies, which implies challenges and opportunities.