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Artificial Intelligent (AI)-powered technology is expected to significantly alter the way healthcare is delivered. Artificial Intelligence tools, such as machine learning and deep learning, have shown promise in supporting diagnostic assessments, recommending treatments, guiding surgical care, monitoring patients, supporting population health management, and enhancing drug development research. These tools at varying stages of maturity can also reduce provider burden and increase efficiency by recording digital notes, optimizing operational processes, and automating laborious tasks. Challenges surrounding AI tools include high-quality data access, potentially biased data, inadequate transparency, and uncertainty over liability. Fundamental changes in governmental oversight of health care, industry-hospital communication, the patient-provider relationship, and human-AI cooperation will be necessary to take advantage of the opportunities and overcome the challenges. We need to be critical and at the same time receptive as we embrace AI tools to deliver healthcare. It would be important to maintain human oversight and control to avoid unintended consequences of runaway machines making life and death decisions.