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This narrative review analyzes the body of literature on known physiological mechanisms impacting bipolar disorder (BD) and how patient-centered nutrition in conjunction with prescribed medications may positively impact patient health outcomes. Additional topics include understanding the current state of research on nutrition and BD, impact of specific micronutrient imbalances on BD, dietary tendencies including current research on whole dietary patterns and potential applications for patients with BD. The totality of research included in this review indicate that inflammatory processes play a central role impacting health outcomes in patients with BD which can be addressed with not only medication, but also with targeted nutrition therapy.