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The goal of this work is to construct a mobile application device that has a wide variety of functions which has clinical planning and decision making for heart-lung machine controlling and to assess the users’ level of satisfaction. The app was constructed according to the steps of design, algorithm, and validation, which is based on the ionic framework. The levels of satisfaction with the developed mobile app among 20 perfusionists were assessed by a questionnaire. The project researchers have officially assigned this medical mobile application with the name is Perfusion Assistant app. that can be accessed and used effectively cross platform on iOS and Android. The application is comprised of 5 main categories which includes: a perfusion calculator, myocardial protection chart, drugs details, priming solution, and parameters values. This finding shown that all cardiovascular parameters did not significant differ from Perfusion Assistant app. when compared to manual calculation. User’s satisfaction was at 3.64 ± 0.76 in the first evaluation. After modification with feedback from experts, the satisfaction of this application was evaluated with a 4.13 ± 0.56. Thereby, Perfusion Assistant app. is an application designed in clinical planning and decision of heart-lung machine controlling for perfusionists and medical staff that work in an opened heart surgery arena. Perfusion Assistant app. offers a variety of calculations related to cardiopulmonary bypass including blood flow rate, systemic vascular resistant, priming volume, and predicted hematocrit. Furthermore, Perfusion Assistant app. provides a quick, easy access, and real-time application for cardiopulmonary bypass that user’s satisfaction was a good level.