Home > Medical Research Archives > Issue 149 > Mutations in the CXCR4 gene cause a population shift in the feline lymphoma cell line 3201 surviving feline immunodeficiency virus infection
Published in the Medical Research Archives
Jan 2017 Issue
Mutations in the CXCR4 gene cause a population shift in the feline lymphoma cell line 3201 surviving feline immunodeficiency virus infection
Published on Jan 16, 2017
DOI
Abstract
The feline 3201-S cell line was established from original 3201 cell populations that survived productive infection of feline thymic lymphoma 3201 cells with feline immunodeficiency virus (FIV). The 3201-S cells expressing a mutated CXCR4 are unresponsive to the CXCR4 ligand SDF-1α, and are refractory to FIV reinfection. In this mini-review, possible mechanisms of how the 3201-S cells could restrict FIV infection and could not respond to SDF-1α are described and discussed.
Author info
Tadafumi Tochikura, Kenji Motokawa, Yuko Naito, Kinjiro Morimoto
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