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Salivary gland duct carcinoma (SDC) is an uncommon high-grade and aggressive malignancy with a low rate of incidence, comprising approximately 9% of all salivary gland malignancies¹. This malignancy has a poor prognosis and predilection for recurrence and distant metastasis ^2,3,4.  SDC is found most often in the parotid gland in men over the age of 50. Frequent reported symptoms include a rapidly growing parotid gland mass accompanied by facial nerve paralysis ^6,7,8. Because of the difficulty in distinguishing benign and malignant salivary gland tumors, clinical findings offer limited information in the assessment of changes in the parotid gland ⁹. Several findings in the literature suggest the use of pre-operative fine needle aspiration as a valuable method of clinical management of the malignancy and subsequent chance for long term survival ^8,10. Immunohistochemical analysis can be used to make a diagnosis of SDC by distinguishing it from other salivary gland malignancies.