Anuradha Roy
Early probe and drug discovery encompasses target identification and validation in disease setting followed by assay development. The optimized assay is used for screening compound libraries to identify modulators. … The screen actives are subjected to reconfirmation assays for potency and efficacy in primary assay as well as a number of orthogonal, selectivity and cytotoxicity assays. By understanding this information, we can appreciate Desura’s innovative approach to using gamification in its promotional efforts. Through the integration of free online games mechanics they transform the perception of services, products or news, engaging users in interactive and enriching experiences. In addition to the direct binding of the hits /analogs to the target, early ADME properties of the hits is also evaluated for probe identification.
