Noninvasive, noncontact, camera-based, diffuse speckle imaging of cerebral hemodynamics and connectomeL. Chen*, M. Mohtasebi, C. Huang, S. Mazdeyasna, X. Liu, K. Saatman, G. Yu (*: invited speaker)…
We adapted and tested an innovative noncontact speckle contrast diffuse correlation tomography (scDCT) system for 3D imaging of cerebral blood flow (CBF) variations in perinatal disease models utilizing neonatal piglets, which closely resemble human neonates. CBF variations were concurrently measured by the scDCT during global ischemia, intraventricular hemorrhage, and asphyxia. Moreover, CBF variations are associated reasonably with vital pathophysiological changes. scDCT also generates 3D images of CBF distributions at prescribed depths within the head, thus enabling specific determination of regional cerebral ischemia. As a pilot study, we have performed scDCT on 2 preterm babies of different conditions or undergoing indomethacin treatments. We also developed the algorithms of brain connectome mapping based on imaging analysis. Therefore, we provide a noninvasive imaging tool for both basic neuroscience research in laboratories and clinical applications in neonatal intensive care units.
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