Improving the Accuracy of Serrated Colon Polyp Designation

Article Sidebar

PDF Download
Published Nov 18, 2019
DOI: https://doi.org/10.18103/mra.v7i11.1988

Downloads

Download data is not yet available.

Submit your own article

Register as an author to reserve your spot in the next issue of the Medical Research Archives.

Author Registration

Join the Society

The European Society of Medicine is more than a professional association. We are a community. Our members work in countries across the globe, yet are united by a common goal: to promote health and health equity, around the world.

Join Europe’s leading medical society and discover the many advantages of membership, including free article publication.

Membership

Main Article Content

Neda Zarrin-Khameh Shima Mousavi

Abstract

ABSTRACT


Background: Serrated polyps are the most common polyps of the large bowel. In the past decade, the focus on sessile serrated polyp (SSP) has been increased as it has proved that untreated SSP is associated with substantial increased risk of developing colon cancer. The microscopic diagnosis can be challenging due to overlapping features with hyperplastic polyps, which can cause misdiagnosis and inappropriate follow up of the patients.


Methods: The purpose of this study is to assess the effect of educational sessions on appropriate designation of sessile serrated polyps. We re-evaluated hyperplastic polyps for two years and repeated the re-evaluation after few educational sessions.


Results: During the first phase, we evaluated 365 hyperplastic polyps and reclassified 60 (16%) of them as SSP. We also found 11 tubular adenomas, 2 traditional sessile serrated adenomas and 8 mucosal tags. After the education, phase 2, we reviewed another 191 hyperplastic polyps and reclassified 16 (8%) of them as SSP. We found 3 tubular adenomas, but no other polyps. Most of the polyps (67%) were 0.5 cm in diameter or larger.


Conclusion: Our study shows that the educational intervention was successful in increasing the accurate designation of SSP and improved that significantly.

Keywords: Sessile serrated polyp, hyperplastic polyp, MLH1

Article Details

How to Cite
ZARRIN-KHAMEH, Neda; MOUSAVI, Shima. Improving the Accuracy of Serrated Colon Polyp Designation. Medical Research Archives, [S.l.], v. 7, n. 11, nov. 2019. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/1988>. Date accessed: 24 nov. 2024. doi: https://doi.org/10.18103/mra.v7i11.1988.
ABNT APA BibTeX CBE EndNote - EndNote format (Macintosh & Windows) MLA ProCite - RIS format (Macintosh & Windows) RefWorks Reference Manager - RIS format (Windows only) Turabian
Issue
Vol 7 No 11 (2019): Vol.7 Issue 11, November, 2019
Section
Research Articles

The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.

 

References

1. Leggett B, Whitehall V. Role of the serrated pathway in colorectal cancer pathogenesis. Gastroenterology. 2010; 138:2088-100.
2. Cancer Facts and Figures 2017. American Cancer Society. Page 4. Available at https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and-figures/2017/cancer-facts-and-figures-2017.pdf
Accessed September 11, 2018.
3. Jass JR. Serrated route to colorectal cancer: back street or super highway? J Pathol. 2001;193:283–5.
4. Jass JR, Iino H, Ruszkiewicz. Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum. Gut. 2000;47:43–9.
5. Higuchi T. Jass JR. My approach to serrated polyps of the colorectum. J Clin pathol. 2004 Jul;57(7):682-6.
6. Rex DK. Ahnen DJ, Baron JA. et al. Serrated lesions of the colorectum: review and recommendations from an expert panel. Am J Gastroenterol. 2012 Sep;107(9):1315-29.
7. Liu C, Walker NI, Leggett BA, Whitehall VL, Bettington ML, Rosty C. Sessile serrated adenomas with dysplasia: morphological patterns and correlations with MLH1 immunohistochemistry. Mod Pathol. 2017 Dec; 30 (12)::1728-1738
8. Abdeljawad K, Vemulapalli KC, Kahi C et al. Sessile serrated polyp prevalence determined by a colonoscopist with a high lesion detection rate and an experienced pathologist. Gastrointest Endosc. 2015 Mar;81(3):517-24.
9. Torlakovic E, Snover DC. Gastroenterology. 1996 Mar;110(3):748-55.
10. Spring KJ, Zhao ZZ, Karamatic R, et al. High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy. Gastroenterology. 2006 Nov; 131(5):1400-7.
11. Snover DC. Update on the serrated pathway to colorectal carcinoma.. Hum Pathol. 2011 Jan; 42(1):1-10.
12. Jass JR. Classification of colorectal cancer based on correlation of clinical, morphological and molecular features. Histopathology. 2007 Jan; 50(1):113-30.
13. Torlakovic E1, Snover DC. Sessile serrated adenoma: a brief history and current status. Crit Rev Oncog. 2006 Jul;12(1-2):27-39
14. Bosman FT, Caneiro F, Hruban RH et al. WHO classification of tumors of the digestive system, WHO 4th edition
15. Gupta V, East JE. Optimal endoscopic treatment and surveillance of serrated polyps.
Gut Liver. 2019 Oct 8. doi: 10.5009/gnl19202
16. Ijspeert JE, Madani A, Overbeek LI, Dekker E, Nagtegaal ID. Implementation of an e-learning nodule improves consistency in the histopathological diagnosis of sessile serrated lesion within a nationwide population screening program. Histopathology 2017 May; 70 (6): 929-937