Application of a β-mannanase enzyme in diets with a reduced net energy content in post-weaning piglets resulted in equal performance and an additional economic benefit

Main Article Content

Frédéric ACJ Vangroenweghe Sarah Goethals Delphine Van Zele Anne de Bruijn

Abstract

β-Mannans are strongly anti-nutritive polysaccharide fibers found in most vegetable feed ingredients. The estimated content of soluble β-mannans in common swine diets range from 0.15 to 0.40%. In vitro studies have demonstrated that as little as 0.05% soluble β-mannan content in feed can elicit a strong innate immune response. Hemicell HT (Elanco Animal Health) is a β-mannanase enzyme for animal feed that breaks down β-mannans, thereby preventing economic losses from the wasteful immune response to β-mannans. The present study aimed to compare pig performance on a control diet and a reformulated diet with a lower energy content – 45 kcal/kg NE reduction – and the inclusion of a β-mannanase enzyme. A six-week feeding trial was conducted on a commercial post-weaning facility with DanBred x Belgian Piétrain pigs starting at 21 days of age. Standard three-phase control diets were compared to reformulated diets with an energy reduction of 45 kcal NE/kg and inclusion of a β-mannanase enzyme (Hemicell HT; Elanco) at 300 g/tonne. Standard production data were collected. The data were analyzed using JMP 15.0 statistical program. Overall, performance data did not differ significantly between trial groups in both Phase 1 and Phase 2, and overall, during the entire post-weaning period. Mortality was only numerically, but not significantly higher in the Control as compared to the Hemicell HT group. Hemicell HT had an overall benefit of € 1.69 per piglet and € 15.18 per tonne of feed due to the 45 kcal/kg NE reduction. The current trial demonstrated that the inclusion of Hemicell HT in reformulated diets with a lower energy content (45 kcal NE/kg) was able to retain production performance in post-weaned piglets with an economic benefit.

Keywords: β-mannanase, post-weaned pigs, net energy reduction, equal performance, economic benefit

Article Details

How to Cite
VANGROENWEGHE, Frédéric ACJ et al. Application of a β-mannanase enzyme in diets with a reduced net energy content in post-weaning piglets resulted in equal performance and an additional economic benefit. Medical Research Archives, [S.l.], v. 11, n. 6, june 2023. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/3954>. Date accessed: 15 may 2024. doi: https://doi.org/10.18103/mra.v11i6.3954.
Section
Research Articles

References

1. Klein J, Williams M, Brown B, Rao S, Lee TJ. Effects of dietary inclusion of a cocktail NSPase and β-mannanase separately and in combination in low energy diets on broiler performance and processing parameters. J Appl Poult Res. 2015;24:489-501.

2. Ferrel J, Anderson, DM, Hsiao, H-Y. Content of soluble non-starch polysaccharides β-mannan and xylan in legume meals, non-legume meals, and cereal grains or cereal grain by-products. J Anim Sci. 2014; 92:Abstract #328

3. Hsiao H-Y, Anderson DM, Dale NM. Levels of β-mannan in soybean meal. Poult Sci. 2006;85:1430-1432.

4. Jackson ME, Geronian K, Knox A, McNab J, McCartney E. A dose-response study with the feed enzyme β-mannanase in broilers provided with corn-soybean meal based diets in the absence of antibiotic growth promoters. Poult Sci. 2004;83:1992-1996.

5. Forsberg NE, Wang Y. Nutrition and immunity in dairy cattle: implications to hemorrhagic bowel syndrome. Proc Mid-South Rum Nutr Conf. 2006;11-20.

6. Sukhithasri V, Nisha N, Biswas L, Kumar VA, Biswas R. Innate immune recognition of microbial cell wall components and microbial strategies to evade such recognitions. Microbiol. Res. 2013;168:396-406.

7. Anderson DM, Hsiao HY, Dale NM. 2008. Identification of an inflammatory compound for chicks in soybean meal. Poult Sci. 2008;88:153-157.

8. Li Y, Chen X, Chen Y, Li Z, Cao Y. Effects of β-mannanase expressed by Pichia pastoris in corn soybean meal diets on broiler performance, nutrient digestibility, energy utilization and immunoglobulin levels. Anim Feed Sci. Technol. 2010;159:59-67.

9. Arsenault RJ, Lee JT, Latham R, Carter B, Kogut MH. Changes in immune and metabolic gut response in broilers fed β-mannanase in β-mannan-containing diets. Poult Sci. 2017;96:4307-3216.

10. La Rosa SL, Leth ML, Michalak L, Hansen ME, Pudlo NA, Glowacki R, Pereira G, Workman CT, Arntzen MØ, Pope PB, Martens EC, Hachem MA, Westereng B. The human gut Firmicute Roseburia intestinalis is a primary degrader of dietary β-mannans. Nat Commun. 2019;10:905-918.

11. Rainbird AL, Low AG, Zebrowska T. Effect of guar gum on glucose and water absorption from isolated loops of jejunum in conscious growing pigs. Br J Nutr. 1984;52:489-498.

12. Pettey LA, Carter SD, Senne BW, Shriver JA. Effects of beta-mannanase addition to corn-soybean meal diets on growth performance, carcass traits, and nutrient digestibility of weanling and growing-finishing pigs. J. Anim. Sci. 2002;80:1012-1019.

13. Balasubramanian B, Ingale SL, Park JH, Rathi PC, Shanmugam S. Kim IH. Inclusion of dietary β-mannanase improves performance and ileal digestibility and reduces ileal digesta viscosity of broilers fed corn-soybean meal-based diet. Poult Sci. 2018;97:3097-3101.

14. Jackson ME, Anderson DM, Hsiao HY, Mathis GF, Fodge DW. Beneficial effect of β-mannanase feed enzyme on performance of chicks challenged with Eimeria sp. and Clostridium perfringens. Av Dis. 2003;47:759-763.

15. Kim JS, Ingale SL, Hosseindoust AR, Lee SH, Lee JH, Chae BJ. Effects of mannan level and β-mannanase supplementation on growth performance, apparent total tract digestibility and blood metabolites of growing pigs. Animal 2017;11:202-208.

16. Jo JK, Ingale SL, Kim JS, Kim YW, Kim KH, Lohakare JD. Lee JH, Chae BJ. Effects of exogenous enzyme supplementation to corn- and soybean meal-based or complex diets on growth performance, nutrient digestibility, and blood metabolites in growing pigs. J Anim Sci. 2012;90:3041-3048.

17. Lv JN, Chen YQ, Guo XJ, Piao XS, Cao YH, Dong B. 2013. Effects of supplementation of β-mannanase in corn-soybean meal diets on performance and nutrient digestibility in growing pigs. Asian-Aust J Anim Sci. 2013;26:579-587.

18. Upadhaya SD, Park JW, Lee JH, Kim IH. 2016. Efficacy of β-mannanase supplementation to corn-soya bean meal-based diets on growth performance, nutrient digestibility, blood urea nitrogen, faecal coliform and lactic acid bacteria and feacal noxious gas emission in growing pigs. Arch Anim Nutr. 2016;70:33-43.

19. Ibuki M, Fukui K, Kanatani H, Mine Y. Anti-inflammatory effects of mannanase-hydrolyzed copra meal in a porcine model of colitis. J Vet Med Sci. 2014;76:645-651.

20. Humphrey BD, Klasing KC. The acute phase response alters cationic amino acid transporter expression in growing chickens (Gallus gallus domesticus). Comp Biochem Physiol A Mol Integr Physiol. 2005;142:485-494.

21. Vangroenweghe F, Poulsen K, Thas O. Supplementation of a β-mannanase enzyme reduces post-weaning diarrhea and antibiotic use in piglets on an alternative diet with additional soybean meal. Porc. Health Man. 2021;7:8-19.

22. Hsiao H-Y, Anderson DM, Jin FL, Mathis GF. Efficacy of β-mannanase (Hemicell) in broiler chickens infected with necrotic enteritis. Poult Res. 2004;1790.