The European Society of Medicine launched this policy framework to address a growing threat to public health. In the face of a persistent decline in vaccine confidence, Europe confronts a critical juncture in its vaccination strategy. Despite the availability of effective vaccines, undervaccination remains a pressing issue, with significant implications for community health and safety. Most initiatives to increase vaccination rates focus on accessibility but fail to address the public’s lack of confidence in vaccines. The framework calls for collaboration between governments, healthcare providers, patient advocacy groups and the private sector to change this.