Neurodegenerative diseases are increasingly prevalent in Europe, posing significant challenges to healthcare systems and economies. This policy framework provides a roadmap for tackling these complex conditions through a multifaceted approach that includes advancements in diagnostics, treatment modalities, long-term management strategies and equitable access to care. It calls on governments to allocate the resources needed to support research, to equip healthcare providers with advanced diagnostic and treatment tools, and to ensure equitable access to care for all populations, especially the vulnerable and underserved.