Oral tissue engineering has focused on the reconstruction of hard and soft tissues associated with chronic disease or trauma. Successful reconstruction involves requisite cells, scaffolds and proper environmental… factors to induce tissue regeneration. Soft tissue augmentation clinical procedures have evolved past autogenous treatment and research is underway to investigate modalities to enhance cell proliferation and migration. Likewise, oral bone augmentation procedures and tissue engineering advancements include bone morphogenic proteins and mesenchymal stem cells to improve osteogenic potential. This presentation will review current as well as investigational therapies in oral tissue engineering.