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Circadian rhythms are significant in coordinating and adjusting daily behavioural and physiological activities from bacteria to humans. The molecular component of the circadian rhythms in D. melanogaster is widely studied. This system is made up of transcriptional-translational autoregulatory feedback loops. Recent studies reveal there is a general homologue of circadian genes found within the molecular clock; however, the results shown in other holometabolous insects could somewhat differ from that of D. melanogaster. There has been tremendous progress in the identification of genes over the years, which regulates transcription has broadened the scope of our understanding revealing cellular and molecular mechanisms, yet the roles these genes play in holometabolous insects are not well discussed. In this review, we tend to prefer to display an outline of the present comprehension of the roles circadian rhythms play in holometabolous insects.
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