Chronic Pulmonary Complications of Sickle Cell Disease
Improvement of Obstructive Sleep Apnea (OSA) therapy with Pressure Oscillation
OSA is on one of the leading lung diseases worldwide. There is no cure for such a disease despite many limited partially successful surgical operations. The gold standard for OSA therapy is the Continuous positive airway (CPAP) device. … The CPAP therapy has many advantages including reducing the Apnea-hypopnea index and helping patients to breath better during their sleep. However, this is associated with many side effects including but are limited to upper airways dryness and the high titration pressure. Our hypothesis is that superimposed pressure oscillation on a reduced titration pressure will help to modulate the upper airways muscles and stimulate the salivary glands to produce more saliva. This will lead to a new therapy approach. Clinical trials have clearly showed the advantage of this therapy over the traditional CPAP approach.