Successful treatment with short-course Daptomycin lock and systemic therapy in two cases of catheter-related bloodstream infections due to uncommon pathogensing catheter-related bloodstream infections due to uncommon pathogens

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Jean Michel Dubertrand Nicolas Weiss Serge Scales Pierre Luc Genillier Dominique Neri Brigitte Dunais Regis Kaphan


Short-course Daptomycin lock and systemic therapy for treating catheter-related bloodstream infections due to uncommon pathogens. Treatment of catheter-related bloodstream infections (CRSBI) is one of current major challenges in management of long-term catheters. Daptomycin has proved its efficacy as lock therapy for treating CRSBI due to coagulase negative Staphylococci. Here we describe two cases of successful treatment with short course Daptomycin as lock and systemic therapy for CRSBI due to uncommon pathogens, thus bringing new insights about strategies for a conservative management of devices.

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DUBERTRAND, Jean Michel et al. Successful treatment with short-course Daptomycin lock and systemic therapy in two cases of catheter-related bloodstream infections due to uncommon pathogensing catheter-related bloodstream infections due to uncommon pathogens. Medical Research Archives, [S.l.], v. 5, n. 2, feb. 2017. ISSN 2375-1924. Available at: <>. Date accessed: 20 sep. 2021.
Antibiotic lock therapy; Daptomycin
Case Reports


1. Ziegler MJ, Pellegrini DC, Safdar N. Attributable mortality of central-line associated bloodstream infection: systematic review and meta-analysis. Infection 43; 29-36 (2014)
2. Nesher L, Rolston KV. The current spectrum of infection in cancer patients with chemotherapy related neutropenia. Infection 42; 5-13 (2014)
3. “Preventing central-line associated bloodstream infections. A global challenge, a global Perspective”. (2013). [no author]
4. Fagan RP, Edwards JR, Park BJ, Fridkin SK, Magill SS. Incidence trends in pathogen-specific central line-associated bloodstream infections in US intensive care units, 1990-2000. Infect Control Hosp Epidemiol. 34; 893-9 (2013)
5. R. M. Donlan. Biofilms and device-associated infections. Emerg Infect Dis. 7; 277-81 (2001)
6. L. A. Mermel, M. Allon, E. Bouza, D. E. Craven, P. Flynn et al. Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis. 49; 1-45 (2009)
7. R. Estes, J. Theusch, A. Beck, D. Pitrak, K.M. Mullane. Activity of Daptomycin with or without 25 percent ethanol compared to combinations of Minocycline, EDTA, and 25 percent ethanol against methicillin-resistant Staphylococcus aureus isolates embedded in biofilm. Antimicrob Agents Chemother. 57; 1998-2000 (2013)
8. C. Aumeran, P. Guyot, M. Boisnoir, C. Robin-Hennequin, M. Vidal et al. Activity of ethanol and daptomycin lock on biofilm generated by an in vitro dynamic model using real subcutaneous injections ports. Eur J Clin Microbiol Infect Dis. 32: 199-206 (2013)
9. Y. Meije, B. Almirante, J. L. Del Pozo, M. T. Martin, N. Fernandez-Hidalgo et al. Daptomycin is effective as antibiotic-lock therapy in a model of Staphylococcus aureus catheter-related infection. J Infect. 69; 548-52 (2014)
10. E. Castagnola, L. Amoroso, L. Banov, M. Faraci, A. Loy et al. Activity of linezolid and daptomycin against methicillin-resistant coagulase-negative staphylococci with increased MIC for vancomycin isolated from blood cultures in pediatric patients. J Chemother 26; 273-5 (2015)
11. K. L. LaPlante, L. A. Mermel. In vitro activity of daptomycin and vancomycin lock solutions on staphylococcal biofilms in a central venous catheter model. Nephrol Dial Transplant 22; 2239-46 (2007)
12. J. C. O’Horo, G. L. M. Silva, N. Safdar. Anti-infective locks for treatment of central line-associated bloodstream infection: a systematic review and meta-analysis. Am J Nephrol. 34; 415-22 (2011)
13. N. P. O’Grady, M. Alexander, L. A. Burns, E. P. Dellinger, J. Garland et al. Guidelines for the prevention of intravascular catheter-related infections. Clin Infect Dis. 39; S1-34 (2011)
14. LaPlante KL, Woodmansee S. Activities of daptomycin and vancomycin alone and in combination with rifampin and gentamicin against biofilm-forming methicillin-resistant Staphylococcus aureus isolates in an experimental model of endocarditis. Antimicrob Agents Chemother. 53; 3880-6 (2009)
15. M. Vassallo, P. L. Genillier, B. Dunais, R. Kaphan, L. Saudes et al. Short-course Daptomycin lock and systemic therapy for catheter-related bloodstream infections: a retrospective cohort study in cancer patients with surgically implanted devices. J. Chemother
doi 10.1080/1120009X.2017.1282335 (2017)
16. P. Provonost, D. Needahm, S. Berenholtz. An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med. 355; 2725-32 (2006)
17. A. D. G. Van Praagh, T. Li, S. Zhang, A. Arya, L. Chen et al. Daptomycin antibiotic lock therapy in a rat model of Staphylococcal central venous catheter biofilm infections. Antimicrob Agents Chemother. 55; 4081-9 (2011)
18. J. L. Del Pozo, R. Rodil, A. Aguinada, J. R. Yuste, C. Bustos et al. Daptomycin lock therapy for gram positive long-term catheter-related bloodstream infections. Int J Clin Pract 66; 305-8 (2012)
19. M. B. Bestul, H. L. VandenBussche. Antibiotic lock technique: review of the literature. Pharmacotherapy 25; 211-227 (2005)
20. O. Cirioni, F. Mocchegiani, R. Ghiselli, C. Silvestri, E. Gabrielli et al. Daptomycin and Rifampin alone and in combination prevent vascular graft biofilm formation and emergence of antibiotic resistance in a subcutaneous rat pouch model of Staphylococcal infection. Eur J Vasc Endovasc Surg. 40; 817-22 (2010)
21. A. J. Probst, C. Hertel, L Richter, L. Wassill, W. Ludwig et al. Staphylococcus condimenti sp. nov., from soy sauce mash, and Staphylococcus carnosus (Schleifer and Fischer 1982) subsp. utilis subsp. nov. Int J Syst Bacteriol. 48; 651-8 (1998)
22. Y. Misawa, A. Yoshida, S. Okugawa, K. Moriya. First reported case of Staphylococcus condimenti infection associated with catheter-related bacteraemia. New Microbes New Infect. 3;18-20 (2014)
23. H. S. Yang, Y. J. Kim, S. Y. Cho, E. Shin, H. J. Lee. Central venous catheter-related bloodstream infection by Corynebacterium striatum identified by 16S rRNA and rpoB gene sequencing. Ann Lab Med. 35; 548-50 (2015)
24. C. M. Wojewoda, C. E. Koval, D. A. Wilson, M. H. Chakos, S. M. Harrington. Bloodstream infection caused by nontoxigenic Corynebacterium diphtheriae in an immunocompromised host in the United States. J Clin Microbiol. 50; 2170-2 (2012)
25. F. L. Chen, P. R. Hsueh, S. O. Teng, T. Y. Ou, W. S. Lee. Corynebacterium striatum bacteremia associated with central venous catheter infection. J Microbiol Immunol Infect. 45; 255-8 (2012)
26. S Ghide, Y. Jiang, R. Hachem, A. M. Chaftari, I. Raad. Catheter-related Corynebacterium bacteremia: should the catheter be removed and vancomycin administered? Eur J Clin Microbiol Infect Dis. 29; 153-6 (2010)
27. J. L. Del Pozo, M. Alonso, A. Serrera, S. Hernaez, A. Aguinaga et al. Effectiveness of the antibiotic lock therapy for the treatment of port-related enterococci, Gram-negative, or Gram-positive bacilli bloodstream infections. Diagn Microbiol Infect Dis. 63; 208-12 (2009)
28. P. Tatarelli, A. Parisini, V. Del Bono, M. Mikulska, C. Viscoli. Efficacy of daptomycin lock therapy in the treatment of bloodstream infections related to long-term catheter. Infection. 43; 107-9 (2014)