Successful treatment with short-course Daptomycin lock and systemic therapy in two cases of catheter-related bloodstream infections due to uncommon pathogensing catheter-related bloodstream infections due to uncommon pathogens

Short-course Daptomycin lock and systemic therapy for treating catheter-related bloodstream infections due to uncommon pathogens. Treatment of catheter-related bloodstream infections (CRSBI) is one of current major challenges in management of long-term catheters. Daptomycin has proved its efficacy as lock therapy for treating CRSBI due to coagulase negative Staphylococci. Here we describe two cases of successful treatment with short course Daptomycin as lock and systemic therapy for CRSBI due to uncommon pathogens, thus bringing new insights about strategies for a conservative management of devices.