Fluoridation Practices - A Missing Link in the Vaccine Autism Connection?

Main Article Content

Robert Jay Rowen


Autism Spectrum Disorder (ASD) rates around the world are skyrocketing for unknown reasons. Parents have fingered vaccines but studies have failed to confirm a link. Concurrently, aluminum, from vaccine adjuvants, has been found actively transported to the brains of animals inciting inflammation. Fluoride has been implicated in children’s brain dysfunction, and, fluoride has been shown to potentiate aluminum toxicity. No vaccine study to date has controlled for a practice widespread around the world – water fluoridation. Autism is more prevalent in United States cities that fluoridate their water supplies, and less prevalent in rural non-fluoridated areas even with high vaccination rates. This manuscript presents basic science and a hypothesis that fluoride could be potentiating the toxic neurological effects of aluminum in vaccines. This effect could lead to skewed data and confounding vaccine safety statistics by omission of this critical control factor. 

Article Details

How to Cite
ROWEN, Robert Jay. Fluoridation Practices - A Missing Link in the Vaccine Autism Connection?. Medical Research Archives, [S.l.], v. 5, n. 2, feb. 2017. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/1041>. Date accessed: 30 july 2021.
autism; autism spectrum disorders; fluoride; aluminum; vaccines
Review Articles


Kern JK, Geier DA, Sykes LK, Haley BE, Geier MR, The relationship between mercury and autism: A comprehensive review and discussion. Trace Elem Med Biol. 2016 Sep;37:8-24. .
Plotkin, S., Section Editor, Jeffrey S. Gerber, J.S., and Paul A. Offit, Vaccines and Autism: A Tale of Shifting Hypotheses, Clinical Infectious Diseases 2008; Volume 48, Issue 4:. 456-461.
National Academies Press (US); 2011 Aug 25 (http://www.ncbi.nlm.nih.gov/pubmed/24624471)
Schubert J, Riley EJ, Tyler SA. Combined effects in toxicology - a rapid systematic testing procedure: cadmium, mercury, and lead. J Toxicol Environ Health 1978; 4: 763–776.
Aluminum Toxicity in Infants and Children, Committee on Nutrition,American Academy of Pediatrics, Pediatrics Volume 97, Number 3 March, 1996, pp. 413-416
Shaw CA1, Tomljenovic L. Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity. Immunol Res. 2013; Jul;56(2-3):304-16.
Tomljenovic L1, Shaw CA. Do aluminum vaccine adjuvants contribute to the rising prevalence of autism? J Inorg Biochem. 2011; Nov;105(11):1489-99.
Gherardi, R., Eidi, H., Crépeaux, G., Authier, F., Cadusseau, J., Biopersistence and brain translocation of aluminum adjuvants of vaccines. Front. Neurol., 05 February 2015
Inbar, R., Weiss, R., Tomljenovic, L., Arango, MT, Deri, Y., Shaw, C., Chapman, J., Blank, M., Shoenfeld, Y., Behavioral abnormalities in female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil, Immunol Res (2016). doi:10.1007/s12026-016-8826-6
Miller, N., Aluminum in childhood vaccines is Unsafe. Journal of American Physicians and Surgeons Volume 21 Number 4 Winter 2016
Perricone, C., Colafrancesco, S., Mazor R., Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) 2013: Unveiling the pathogenic, clinical and diagnostic aspects. J Autoimmun 2013;47(Dec):1-16.
Choi, A., Guifan, S., Zhang, Y., Grandjean, P., Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis. Environ. Health Perspectives, October 2012, vol. 120, issue 10
Choi AL, Zhang Y, Sun G, Bellinger DC, Wang K, Yang XJ, Li JS, Zheng Q, Fu Y, Grandjean P. Lifetime fluoride exposure and cognitive functions in Chinese children. Association of lifetime exposure to fluoride and cognitive functions in Chinese children: a Pilot Study. Neurotoxicol Teratol. 2015; Jan-Feb;47:96-101. (And, Fluoride 48(2)179-180
April-June 2015.)
Kaur T, Bijarnia RK, Nehru B.,Effect of concurrent chronic exposure of fluoride and aluminum on rat brain. Drug & Chem. Toxicol. (2009); 32(3): 215-21.
Malin AJ, Till C., Exposure to fluoridated water and attention deficit hyperactivity disorder prevalence among children and adolescents in the United States: an ecological association. Environ Health. 2015 Feb 27;14:17.
Varner JA, Jensen KF, Horvath W, Isaacson RL. Chronic administration of aluminum-fluoride or sodium-fluoride to rats in drinking water: alterations in neuronal and cerebrovascular integrity. Brain Res. 1998; Feb 16;784(1-2):284-98.
Tennakone K, Wickramanayake S, Fernando CA., Aluminium contamination from fluoride assisted dissolution of metallic aluminium. Environ Pollut. 1988;49(2):133-43.
Maas RP, Patch SC, Christian AM, Coplan MJ. Effects of fluoridation and disinfection agent combinations on lead leaching from leaded-brass parts. Neurotoxicology. 2007; Sep;28(5):1023-31. Epub 2007 Jun 30.
Kennedy D, Seneff S, Davidson RM, Oller Jr JW, Haley BE, et al. (2016) Environmental Toxicants and Infant Mortality in the USA. Peertechz J Biol Res Dev 1(1): 036-061.
Becker, K., Autism and Urbanization. Am J Public Health; 2010 July; 100(7): 1156–1157
Philippe Grandjean, Philip J Landrigan Neurobehavioural effects of developmental toxicity. Lancet Neurol 2014; 13: 330–38.
Choi, A., Sun, G.,, Zhang, Y., Grandjean, P. Environ Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis.
Health Perspect; DOI:10.1289/ehp.1104912.
Malin AJ, Till C. Exposure to fluoridated water and attention deficit hyperactivity disorder prevalence among children and adolescents in the United States: an ecological association. Environ Health. 2015; 14: 17. (And Fluoride 48(2)i-ii April-June 2015.)
Van Meter, K., Christiansen, L., Delwhiche, L, et. al. Geographic Distribution of Autism in California: A Retrospective Birth Cohort. Autism Res. 2010 Feb; 3(1): 19–29.
Bach, JF., “The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases,” NEJM 2002; Vol. 347:911-920, September 19, 2002.
Schmitz, R., Poethko-Müller, Sabine Reiter, S., Schlaud, M., Vaccination Status and Health in Children and Adolescents. Findings of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS). Dtsch Arztebl Int. 2011 Feb; 108(7): 99–104. Published online 2011 Feb 18. doi: 10.3238/arztebl.2011.0099
Wenger, OK, McManus, MD, Bower, JR, Langkamp, DL, Underimmunization in Ohio's Amish: Parental Fears Are a Greater Obstacle Than Access to Care, Pediatrics. 2011 Jul;128(1): 79-85.
42 U.S.C. §§ 300aa-1 to 300aa-34
Nicolson, T., Mellor, H.,Trends, R., Gender differences in drug toxicity, Pharmacological Sciences 31(3):108-14 62, March 2010
Guillermo, M., Pérez-Schael, I., Velázquez, F., Albate, H., Breuer, T., et. al. Safety and Efficacy of an Attenuated Vaccine against Severe Rotavirus Gastroenteritis. N Engl J Med 2006; 354:11-22
Silbergeld EK1, Schwartz J, Mahaffey K., Lead and osteoporosis: mobilization of lead from bone in postmenopausal women., Environ Res. 1988 Oct;47(1):79-94.