Autophagy in Cardiac Development
Main Article Content
Abstract
The heart is the first functional organ to form during embryogenesis. Cardiac development is a multifactorial complex process requiring precise control of proliferation, differentiation, migration and survival of diverse cell types by interactive networks of genetic and environmental factors. Autophagy is a conserved catabolic pathway that degrades cytoplasmic contents in lysosomes for reutilization. It is well established that autophagy regulates the development of nervous system, osseous tissue, adipose tissue and lymphocyte. Recent evidences on the basis of in vitro cell culture systems as well as in vivo animal models suggest essential roles of autophagy in cardiogenesis. In this review, we summarize the major findings regarding emerging roles of autophagy and autophagy-related genes in cardiac development, which implicates autophagy in human congenital heart disease, the leading human birth defect worldwide.
Article Details
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.