Attenuating the coagulation cascade with annexin A5
Main Article Content
Abstract
Membrane displayed phosphatidylserine (PS) on platelets, microparticles, endothelial cells and erythrocytes is the platform for the coagulation cascade and annexin A5’s great affinity for PS allows it to bind to it and form a shield that can block the cascade. In spite of this significant anticoagulant ability annexin A5 has no therapeutic anticoagulant application. Why?
Article Details
How to Cite
KENNEDY, James.
Attenuating the coagulation cascade with annexin A5.
Medical Research Archives, [S.l.], n. 3, july 2015.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/113>. Date accessed: 16 dec. 2024.
Keywords
phosphatidylserine, annexin A5, infarct, protein C, coagulation
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References
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Matsuda R1, Kaneko N, Kikuchi M, Chiwaki F, Toda M, Ieiri T, Horikawa Y, Shimizu M, Shimamoto K. : Clinical significance of measurement of plasma annexin V concentration of patients in the emergency room. Resuscitation. 2003 May;57(2):171-7. (abstract) http://www.ncbi.nlm.nih.gov/pubmed/?term=Matsuda+Clinical+significance+of+measurement+of+plasma+annexin+V+concentration
Rand ML1, Wang H, Pluthero FG, Stafford AR, Ni R, Vaezzadeh N, Allison AC, Kahr WH, Weitz JI, Gross PL.: Diannexin, an annexin A5 homodimer, binds phosphatidylserine with high affinity and is a potent inhibitor of platelet-mediated events during thrombus formation. J Thromb Haemost. 2012 Jun;10(6):1109-19. doi: 10.1111/j.1538-7836.2012.04716.x. (abstract) http://www.ncbi.nlm.nih.gov/pubmed/?term=Diannexin%2C+an+annexin+A5+homodimer%2C+binds+phosphatidylserine+with+high+affinity+Rand
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Tzima E, Trotter PJ, Orchard MA, Walker JH.: Annexin V relocates to the platelet cytoskeleton upon activation and binds to a specific isoform of actin. Eur J Biochem. 2000 Aug;267(15):4720-30 C (abstract) http://www.ncbi.nlm.nih.gov/pubmed/?term=Tzima+E%2C+Trotter+PJ%2C+Orchard+MA%2C+Walker+JH.%3A+Annexin+V+relocates+to+the+platelet+cytoskeleton+upon+activation+and+binds+to+a+specific+isoform+of+actin. (text) http://onlinelibrary.wiley.com/doi/10.1046/j.1432-1327.2000.01525.x/pdf
Van Ryn-McKenna J1, Merk H, Müller TH, Buchanan MR, Eisert WG. The effects of heparin and annexin V on fibrin accretion after injury in the jugular veins of rabbits. Thromb Haemost. 1993 Mar 1;69(3):227-30. (abstract) http://www.ncbi.nlm.nih.gov/pubmed/?term=Van+Ryn-McKenna+J1%2C+Merk+H%2C+M%C3%BCller+TH%2C+Buchanan+MR%2C+Eisert+WG.+The+effects+of+heparin+and+annexin+V+on+fibrin+accretion
van Tits LJ, van Heerde WL, Landburg PP, Boderie MJ, Muskiet FA, Jacobs N, DuitsAJ, Schnog JB.: Plasma annexin A5 and microparticle phosphatidylserine levels are elevated in sickle cell disease and increase further during painful crisis. Biochem Biophys Res Commun. 2009 Dec 4;390(1):161-4. doi: 10.1016/j.bbrc.2009.09.102. Epub 2009 Sep 30. (abstract) http://www.ncbi.nlm.nih.gov/pubmed/?term=Plasma+annexin+A5+and+microparticle+phosphatidylserine+levels+are+elevated+in+sickle+cell+disease
Galili U, Clark MR, Shohet SB: Excessive binding of natural anti-alpha-galactosylimmunoglobin G to sickle erythrocytes may contribute to extravascular cell destruction. J Clin Invest. 1986 Jan;77(1):27-333. (text) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC423303/
Heemskerk JW1, Bevers EM, Lindhout T. Platelet activation and blood coagulation. Thromb Haemost. 2002 Aug;88(2):186-93. (Text) http://williams.medicine.wisc.edu/plateletactivation.pdf
Matsuda R1, Kaneko N, Kikuchi M, Chiwaki F, Toda M, Ieiri T, Horikawa Y, Shimizu M, Shimamoto K. : Clinical significance of measurement of plasma annexin V concentration of patients in the emergency room. Resuscitation. 2003 May;57(2):171-7. (abstract) http://www.ncbi.nlm.nih.gov/pubmed/?term=Matsuda+Clinical+significance+of+measurement+of+plasma+annexin+V+concentration
Rand ML1, Wang H, Pluthero FG, Stafford AR, Ni R, Vaezzadeh N, Allison AC, Kahr WH, Weitz JI, Gross PL.: Diannexin, an annexin A5 homodimer, binds phosphatidylserine with high affinity and is a potent inhibitor of platelet-mediated events during thrombus formation. J Thromb Haemost. 2012 Jun;10(6):1109-19. doi: 10.1111/j.1538-7836.2012.04716.x. (abstract) http://www.ncbi.nlm.nih.gov/pubmed/?term=Diannexin%2C+an+annexin+A5+homodimer%2C+binds+phosphatidylserine+with+high+affinity+Rand
Thiagarajan P1, Tait JF.: Collagen-induced exposure of anionic phospholipid in platelets and platelet-derived microparticles. J Biol Chem. 1991 Dec 25;266(36):24302-7. (abstract) http://www.ncbi.nlm.nih.gov/pubmed/?term=Thiagarajan+P1%2C+Tait+JF.%3A+Collagen-induced+exposure+of+anionic+phospholipid+in+platelets+and+platelet-derived+microparticles (text) http://www.jbc.org/content/266/36/24302.long
Thiagarajan P1, Benedict CR.: Inhibition of arterial thrombosis by recombinant annexin V in a rabbit carotid artery injury model. Circulation. 1997 Oct 7;96(7):2339-47. (abstract) http://www.ncbi.nlm.nih.gov/pubmed/?term=Thiagarajan+P1%2C+Benedict+CR.%3A+Inhibition+of+arterial+thrombosis+by+recombinant+annexin+V (text) http://circ.ahajournals.org/content/96/7/2339.long
Tzima E, Trotter PJ, Orchard MA, Walker JH.: Annexin V relocates to the platelet cytoskeleton upon activation and binds to a specific isoform of actin. Eur J Biochem. 2000 Aug;267(15):4720-30 C (abstract) http://www.ncbi.nlm.nih.gov/pubmed/?term=Tzima+E%2C+Trotter+PJ%2C+Orchard+MA%2C+Walker+JH.%3A+Annexin+V+relocates+to+the+platelet+cytoskeleton+upon+activation+and+binds+to+a+specific+isoform+of+actin. (text) http://onlinelibrary.wiley.com/doi/10.1046/j.1432-1327.2000.01525.x/pdf
Van Ryn-McKenna J1, Merk H, Müller TH, Buchanan MR, Eisert WG. The effects of heparin and annexin V on fibrin accretion after injury in the jugular veins of rabbits. Thromb Haemost. 1993 Mar 1;69(3):227-30. (abstract) http://www.ncbi.nlm.nih.gov/pubmed/?term=Van+Ryn-McKenna+J1%2C+Merk+H%2C+M%C3%BCller+TH%2C+Buchanan+MR%2C+Eisert+WG.+The+effects+of+heparin+and+annexin+V+on+fibrin+accretion
van Tits LJ, van Heerde WL, Landburg PP, Boderie MJ, Muskiet FA, Jacobs N, DuitsAJ, Schnog JB.: Plasma annexin A5 and microparticle phosphatidylserine levels are elevated in sickle cell disease and increase further during painful crisis. Biochem Biophys Res Commun. 2009 Dec 4;390(1):161-4. doi: 10.1016/j.bbrc.2009.09.102. Epub 2009 Sep 30. (abstract) http://www.ncbi.nlm.nih.gov/pubmed/?term=Plasma+annexin+A5+and+microparticle+phosphatidylserine+levels+are+elevated+in+sickle+cell+disease