Attenuating the coagulation cascade with annexin A5

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James Kennedy


Membrane displayed phosphatidylserine (PS) on platelets, microparticles, endothelial cells and erythrocytes is the platform for the coagulation cascade and annexin A5’s great affinity for PS allows it to bind to it and form a shield that can block the cascade. In spite of this significant anticoagulant ability annexin A5 has no therapeutic anticoagulant application. Why?  

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How to Cite
KENNEDY, James. Attenuating the coagulation cascade with annexin A5. Medical Research Archives, [S.l.], n. 3, july 2015. ISSN 2375-1924. Available at: <>. Date accessed: 25 sep. 2023.
phosphatidylserine, annexin A5, infarct, protein C, coagulation


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