Platelet Rich Plasma: Current Indications and Use In Orthopaedic Care
Main Article Content
Abstract
“Platelet Rich Plasma” (PRP) is a ubiquitous term for a type of therapy that applies autologous platelets collected from whole blood and then concentrated via centrifuge that are re-applied to injured musculoskeletal tissue. The intent of most PRP therapies is to locally create or support a “healing response,” that instigates earlier healing, or to initiate a response in chronic degenerative and painful tissue. Complicating research efforts are the high number of different types and methods of PRP therapies, and the multiple anatomic and tissue sites of treatment that may potentially benefit from PRP. One of the greatest challenges in the development of PRP therapy have been translating promising laboratory and animal study results to clinical studies’ outcomes. While enthusiasm for PRP therapy has often exceeded the evidence to support therapeutic benefits, recent studies and experience does support the use of specific types of PRP therapy in specific degenerative and injury patterns.
Article Details
How to Cite
ROBINS, Richard Judd.
Platelet Rich Plasma: Current Indications and Use In Orthopaedic Care.
Medical Research Archives, [S.l.], v. 5, n. 6, june 2017.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/1293>. Date accessed: 16 dec. 2024.
Keywords
Platelet Rich Plasma; Tendinosis; Osteoarthritis; Injection Therapy
Section
Review Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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3. Braun, H. J., Kim, H. J., Chu, C. R., & Dragoo, J. L. (2014). The effect of platelet-rich plasma formulations and blood products on human synoviocytes: implications for intra-articular injury and therapy. Am J Sports Med, 42(5), 1204-1210. doi:10.1177/0363546514525593
4. Cerza, F., Carni, S., Carcangiu, A., Di Vavo, I., Schiavilla, V., Pecora, A., . . . Ciuffreda, M. (2012). Comparison between hyaluronic acid and platelet-rich plasma, intra-articular infiltration in the treatment of gonarthrosis. Am J Sports Med, 40(12), 2822-2827. doi:10.1177/0363546512461902
5. Charousset, C., Zaoui, A., Bellaiche, L., & Bouyer, B. (2014). Are multiple platelet-rich plasma injections useful for treatment of chronic patellar tendinopathy in athletes? a prospective study. Am J Sports Med, 42(4), 906-911. doi:10.1177/0363546513519964
6. Cole, B. J., Karas, V., Hussey, K., Pilz, K., & Fortier, L. A. (2017). Hyaluronic Acid Versus Platelet-Rich Plasma: A Prospective, Double-Blind Randomized Controlled Trial Comparing Clinical Outcomes and Effects on Intra-articular Biology for the Treatment of Knee Osteoarthritis. Am J Sports Med, 45(2), 339-346. doi:10.1177/0363546516665809
7. Creaney, L., & Hamilton, B. (2008). Growth factor delivery methods in the management of sports injuries: the state of play. Br J Sports Med, 42(5), 314-320. doi:10.1136/bjsm.2007.040071
8. Dai, W. L., Zhou, A. G., Zhang, H., & Zhang, J. (2017). Efficacy of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Meta-analysis of Randomized Controlled Trials. Arthroscopy, 33(3), 659-670 e651. doi:10.1016/j.arthro.2016.09.024
9. Davenport, K. L., Campos, J. S., Nguyen, J., Saboeiro, G., Adler, R. S., & Moley, P. J. (2015). Ultrasound-Guided Intratendinous Injections With Platelet-Rich Plasma or Autologous Whole Blood for Treatment of Proximal Hamstring Tendinopathy: A Double-Blind Randomized Controlled Trial. J Ultrasound Med, 34(8), 1455-1463. doi:10.7863/ultra.34.8.1455
10. de Almeida, A. M., Demange, M. K., Sobrado, M. F., Rodrigues, M. B., Pedrinelli, A., & Hernandez, A. J. (2012). Patellar tendon healing with platelet-rich plasma: a prospective randomized controlled trial. Am J Sports Med, 40(6), 1282-1288. doi:10.1177/0363546512441344
11. de Jonge, S., de Vos, R. J., Weir, A., van Schie, H. T., Bierma-Zeinstra, S. M., Verhaar, J. A., . . . Tol, J. L. (2011). One-year follow-up of platelet-rich plasma treatment in chronic Achilles tendinopathy: a double-blind randomized placebo-controlled trial. Am J Sports Med, 39(8), 1623-1629. doi:10.1177/0363546511404877
12. de Vos, R. J., Weir, A., van Schie, H. T., Bierma-Zeinstra, S. M., Verhaar, J. A., Weinans, H., & Tol, J. L. (2010). Platelet-rich plasma injection for chronic Achilles tendinopathy: a randomized controlled trial. JAMA, 303(2), 144-149. doi:10.1001/jama.2009.1986
13. de Vos, R. J., Windt, J., & Weir, A. (2014). Strong evidence against platelet-rich plasma injections for chronic lateral epicondylar tendinopathy: a systematic review. Br J Sports Med, 48(12), 952-956. doi:10.1136/bjsports-2013-093281
14. DeLong, J. M., Russell, R. P., & Mazzocca, A. D. (2012). Platelet-rich plasma: the PAW classification system. Arthroscopy, 28(7), 998-1009. doi:10.1016/j.arthro.2012.04.148
15. Dines, J. S., Williams, P. N., ElAttrache, N., Conte, S., Tomczyk, T., Osbahr, D. C., . . . Ahmad, C. S. (2016). Platelet-Rich Plasma Can Be Used to Successfully Treat Elbow Ulnar Collateral Ligament Insufficiency in High-Level Throwers. Am J Orthop (Belle Mead NJ), 45(5), 296-300.
16. Dragoo, J. L., Wasterlain, A. S., Braun, H. J., & Nead, K. T. (2014). Platelet-rich plasma as a treatment for patellar tendinopathy: a double-blind, randomized controlled trial. Am J Sports Med, 42(3), 610-618. doi:10.1177/0363546513518416
17. Durant, T. J., Dwyer, C. R., McCarthy, M. B., Cote, M. P., Bradley, J. P., & Mazzocca, A. D. (2017). Protective Nature of Platelet-Rich Plasma Against Chondrocyte Death When Combined With Corticosteroids or Local Anesthetics. Am J Sports Med, 45(1), 218-225. doi:10.1177/0363546516664161
18. Filardo, G., Di Matteo, B., Kon, E., Dhillon, M. S., Patel, S., & Marwaha, N. (2013). Platelet-rich plasma for knee osteoarthritis. Am J Sports Med, 41(9), NP42-43. doi:10.1177/0363546513502635
19. Filardo, G., Di Matteo, B., Kon, E., Merli, G., & Marcacci, M. (2016). Platelet-rich plasma in tendon-related disorders: results and indications. Knee Surg Sports Traumatol Arthrosc. doi:10.1007/s00167-016-4261-4
20. Filardo, G., Kon, E., Buda, R., Timoncini, A., Di Martino, A., Cenacchi, A., . . . Marcacci, M. (2011). Platelet-rich plasma intra-articular knee injections for the treatment of degenerative cartilage lesions and osteoarthritis. Knee Surg Sports Traumatol Arthrosc, 19(4), 528-535. doi:10.1007/s00167-010-1238-6
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