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01 · ABSTRACT

Abstract

Reliable recognition of casual interactions between processes is an issue particularly prevalent in the Neurosciences. When the structure of a network is not a priori known it is almost impossible to observe and measure all components of a system, and missing certain components could potentially lead to the inference of spurious interactions. The aim of this study is to demonstrate the effect of missing components of a network on the inferred strength of a spurious interaction. Our novel method uses vector autoregressive modelling and renormalised partial directed coherence to show how and why the inferred strength of causal interactions between processes changes when components in a network are missed. In cases where a latent confounder is influencing a network and consequently a spurious interaction appears, it is not possible to rely on estimates of the strength of this link as strength estimation methods are influenced by the noise of the latent confounder. Our novel approach demonstrates precisely how a latent confounder can affect the strength measure using analysis of vector autoregressive models. While it is possible to measure the strength of directed causal influences between processes the estimation of strength can be confounded if not all components of a system have been observed during measurement. 

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02 · OJS METADATA

Keywords

Granger causalityVAR modellingrPDClatent confounders
03 · PUBLICATION RECORD

Article details

JournalMedical Research Archives
IssueVol 5 No Issue 9 (2017): Vol.5 Issue 9, September, 2017
SectionResearch Articles
Published18 September 2017
ISSN2375-1924
04 · RIGHTS & REUSE

Rights & reuse

This article is published under a Creative Commons Attribution License (CC BY 3.0) and may be shared or distributed by anyone as long as attribution is given to the journal.

Authors & affiliations

HS

Helen Shiells

Institute for Complex Systems and Mathematical Biology, University of Aberdeen.

MT

Marco Thiel

Institute for Complex Systems and Mathematical Biology, University of Aberdeen.

CW

Claude Wischik

TauRX Therapeutics, Aberdeen. Old Age Psychiatry, University of Aberdeen.

BS

Björn Schelter

Institute for Complex Systems and Mathematical Biology, University of Aberdeen.

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