Prevalence and Distribution of High-Risk Human Papillomavirus Genotypes in Invasive Carcinoma of the Uterine Cervix in Uruguay. An update on clinical outcome
Main Article Content
Nora Berois
http://orcid.org/0000-0002-6372-2540
Fernanda Nozar
Diego Greif
Agustina Franciulli
Enrique Barrios
Eduardo Osinaga
http://orcid.org/0000-0002-6372-2540
Fernanda Nozar
Diego Greif
Agustina Franciulli
Enrique Barrios
Eduardo Osinaga
Abstract
Although the causal role of HPV in cervical cancer CC is accepted, controversial reports have been published about the prognostic significance of different genotypes. Our aim was to evaluate the HPV-status and its relationship with clinical-pathological variables and clinical outcome in invasive cervical cancer of Uruguayan women. Main prevalent genotypes were HPV16 (63.6%), HPV18 and HPV45 (8.3% each genotype), while other genotypes (HPV31, 33, 35, 39, 51, 52, 58, 66, 73 and one undetermined genotype) account for 12.4%, and in 8.3% HPV DNA could not be detected. With a mean follow-up of ten years, we found a significant correlation of overall survival with FIGO staging and lymph node metastasis. Relating to HPV, three prognostic groups were observed. The better clinical outcome was related to genotypes other than HPV16/18/45, while HPV16/18 genotypes belong to an intermediate risk group and the worse prognosis was related to HPV negative and HPV45. HPV independent tumors have been suggested as a different entity compared with virally driven ones. Improvement in knowledge of molecular pathogenesis could impact in CC patients care. In conclusion, worse prognosis was related to HPV negative and HPV45 related tumors. More research is warranted for better understanding molecular basis of virally driven or independent cervical cancer oncogenesis.
Article Details
How to Cite
BEROIS, Nora et al.
Prevalence and Distribution of High-Risk Human Papillomavirus Genotypes in Invasive Carcinoma of the Uterine Cervix in Uruguay. An update on clinical outcome.
Medical Research Archives, [S.l.], v. 5, n. 6, june 2017.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/1303>. Date accessed: 26 dec. 2024.
Keywords
Human Papillomavirus; cervical cancer; prognosis
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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Gadducci A, Barsotti C, Laliscia C, Cosio S, Fanucchi A, Tana R, Fabrini MG. Dose-dense Paclitaxel- and Carboplatin-based NeoadjuvantChemotherapy Followed by Surgery or Concurrent Chemo-radiotherapy in Cervical Cancer: a Preliminary Analysis. Anticancer Res. 2017; 37:1249-55.
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Huang LW, Chao SL, Hwang JL. Human papillomavirus-31-related types predict better survival in cervical carcinoma. Cancer. 2004;100(2):327-34.
Jiamset I, Hanprasertpong J. Risk Factors for Parametrial Involvement in Early-Stage Cervical Cancer and Identification of Patients Suitable for Less Radical Surgery. Oncol Res Treat. 2016; 39(7-8):432-8. doi: 10.1159/000447335.
Kang WD, Kim CH, Cho MK, Kim JW, Cho HY, Kim YH, Choi HS, Kim SM. HPV-18 is a poor prognostic factor, unlike the HPV viral load, in patients with stage IB-IIA cervical cancer undergoing radical hysterectomy. Gynecol Oncol. 2011; 121(3):546-50. doi: 10.1016/j.ygyno.2011.01.015.
Lai CH, Chang CJ, Huang HJ, Hsueh S, Chao A, Yang JE, Lin CT, Huang SL, Hong JH, Chou HH, Wu TI, Huang KG, Wang CC, Chang TC. Role of human papillomavirus genotype in prognosis of early-stage cervical cancer undergoing primary surgery. J Clin Oncol. 2007; 25(24):3628-34.
Lai CH, Chou HH, Chang CJ, Wang CC, Hsueh S, Huang YT, Chen YR, Chang HP, Chang SC, Lin CT, Chao A, Qiu JT, Huang KG, Chen TC, Jao MS, Chen MY, Liou JD, Huang CC, Chang TC, Patsner B. Clinical implications of human papillomavirus genotype in cervical adeno-adenosquamous carcinoma. Eur J Cancer. 2013; 49(3):633-41. doi: 10.1016/j.ejca.2012.09.008.
Landoni F, Colombo A, Milani R, Placa F, Zanagnolo V, Mangioni C. Randomized study between radical surgery and radiotherapy for the treatment of stage IB-IIA cervical cancer: 20-year update. J Gynecol Oncol. 2017; 28:e34. doi.org/10.3802/jgo.2017.28.e34
Lau YM, Cheung TH, Yeo W, Mo F, Yu MY, Lee KM, Ho WC, Yeung AC, Law PT, Chan PK. Prognostic implication of human papillomavirus types and species in cervical cancer patients undergoing primary treatment. PLoS One. 2015; 10(4):e0122557. doi: 10.1371/journal.pone.0122557.
Liu H, Li J, Zhou Y, Hu Q, Zeng Y, Mohammadreza MM. Human papillomavirus as a favorable prognostic factor in a subset of head and neck squamous cell carcinomas: A meta-analysis. J Med Virol. 2017; 89(4):710-725. doi: 10.1002/jmv.24670.
Liu J, Westin SN. Rational selection of biomarker driven therapies for gynecologic cancers: The more we know, the more we know we don't know. Gynecol Oncol. 2016; 141:65-71. doi: 10.1016/j.ygyno.2016.01.003.
Lombard I, Vincent-Salomon A, Validire P, Zafrani B, de la Rochefordière A, Clough K, Favre M, Pouillart P, Sastre-Garau X. Human papillomavirus genotype as a major determinant of the course of cervical cancer. J Clin Oncol. 1998; 16(8):2613-9.
Mabuchi S, Okazawa M, Matsuo K, Kawano M, Suzuki O, Miyatake T, Enomoto T, Kamiura S, Ogawa K, Kimura T. Impact of histologicalsubtype on survival of patients with surgically-treated stage IA2-IIB cervical cancer: adenocarcinoma versus squamous cell carcinoma. Gynecol Oncol. 2012; 127(1):114-20. doi: 10.1016/j.ygyno.2012.06.021
Mai S, Welzel G, Ottstadt M, Lohr F, Severa S, Prigge ES, Wentzensen N, Trunk MJ, Wenz F, von Knebel-Doeberitz M, Reuschenbach M. Prognostic Relevance of HPV Infection and p16 Overexpression in Squamous Cell Anal Cancer. Int J Radiat Oncol Biol Phys. 2015; 93(4):819-27. doi: 10.1016/j.ijrobp.2015.08.004.
Mao S, Dong J, Li S, Wang Y, Wu P. Prognostic significance of number of nodes removed in patients with node-negative early cervical cancer. J Obstet Gynaecol Res. 2016; 42(10):1317-1325. doi: 10.1111/jog.13058.
Meng XY, Liao Y, Liu XP, Li S, Shi MJ, Zeng XT. Concurrent cisplatin-based chemoradiotherapy versus exclusive radiotherapy in high-risk cervical cancer: a meta-analysis. Onco Targets Ther. 2016; 9:1875-88. doi: 10.2147/OTT.S97436.
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