Assessment of a point-of-care device for measuring creatinine in a community screening program for chronic kidney disease

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Published May 18, 2015

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Main Article Content

Brooke Ann Spaeth
Flinders University International Centre for Point-of-Care Testing
Anne K Shephard
Flinders University International Centre for Point-of-Care Testing
Mark DS Shephard
Flinders University International Centre for Point-of-Care Testing
Timothy H Mathew
Kidney Health Australia

Abstract

ABSTRACT

 

Background: Chronic kidney disease (CKD) is a major contemporary global health problem. Creatinine measurement for the calculation of estimated glomerular filtration rate is an important component of assessing CKD risk. A point-of-care test for creatinine using capillary sampling is required as part of a screening assessment.

 

Objectives: Evaluate the analytical performance of a modified point-of-care testing method for whole blood creatinine (Nova Biomedical StatSensor whole blood creatinine analyser) relative to a laboratory method.

 

Design and methods: Conduct a patient comparison study between the point-of-care testing and laboratory methods in a rural community setting. Calculate measures of imprecision and assess the ability of the POCT method to determine staging of CKD compared to the laboratory.

 

Results: Between-device imprecision averaged 8.8%. The StatSensor devices showed a positive bias of approximately 14% for whole blood creatinine measurement compared to the laboratory method, leading to more than 40% of community patients being staged differently for CKD risk with approximately 25% more abnormal results.

 

Conclusions: The StatSensor whole blood creatinine point-of-care device remains analytically unsound for use as a screening device for CKD.

Article Details

How to Cite
SPAETH, Brooke Ann et al. Assessment of a point-of-care device for measuring creatinine in a community screening program for chronic kidney disease. Medical Research Archives, [S.l.], n. 3, may 2015. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/132>. Date accessed: 16 dec. 2024.
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Keywords
chronic kidney disease; point-of-care testing; creatinine; estimated glomerular filtration rate
Issue
No 3 (2015)
Section
Research Articles

The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.

 

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