Comparison of glues, sutures, and other commercially available methods of skin closure: A review of literature

Main Article Content

Christopher David Jones Weiguang Ho Michael Samy Steven Boom Wee Leon Lam


Objectives: Octyl-2-cyanoacrylate (Dermabond) is a soft tissue adhesive that has been approved for topical use to close traumatic lacerations and surgical incisions.   We review paediatric and adult human studies that compared octyl-2-cyanoacrylate with conventional closure techniques in a variety of wounds.

Methods: Medline were searched using a combination of ‘tissue adhesives’, ‘cyanoacrylates’, ‘sutures’, ‘surgical staplers’ and ‘surgical tape’ for paediatric and adult studies comparing skin adhesives with other methods of wound closure. A review was performed using search results screened using predetermined inclusion and exclusion criteria.

Results: We found and summarized 17 studies comparing octyl-2-cyanoacrylate skin glue to conventional methods of skin closure.

Conclusions: Octyl-2-cyanoacrylate skin adhesive produces similar cosmetic results to sutures and other current wound closure techniques while being cost effective, quick and easy to use. Studies suggest that it may be a preferable alternative to sutures.

Article Details

How to Cite
JONES, Christopher David et al. Comparison of glues, sutures, and other commercially available methods of skin closure: A review of literature. Medical Research Archives, [S.l.], v. 5, n. 7, july 2017. ISSN 2375-1924. Available at: <>. Date accessed: 27 feb. 2024.
Tissue adhesives; cyanoacrylates; surgical tape; sutures; wounds; surgical staplers
Review Articles


1. Ellis H. A history of surgery. London: Greenwich Medical Media; 2001.

2. Braun B (2010). A Century of Excellence. Available: Last accessed 10 May 2010.

3. Massachusetts Institute of Technology (2004). Super Glue. Available: Last accessed 10 May 2010.

4. Maloney J, Rogers GS, Kapadia M. Surgical corner: a prospective randomized evaluation of cyanoacrylate glue devices in the closure of surgical wounds. J Drugs Dermatol. 12(7):810-4, 2013 Jul 1.

5. Quinn J, Wells G, Sutcliffe T, et al. Randomized Trial Comparing Octylcyanoacrylate Tissue Adhesive and Sutures in the Management of Lacerations. Journal of the American Medical Association. 1997;277(19):1527-1530.

6. Toriumi DM, O'Grady K, Desai D, et al. Use of Octyl-2-Cyanoacrylate for Skin Closure in Facial Plastic Surgery. Plastic and Reconstructive Surgery. 1998;102(6):2209-2219.

7. Bernard L, Doyle J, Friedlander SF, et al. Prospective Comparison of Octyl Cyanoacrylate Tissue Adhesive (Dermabond) and Suture for the Closure of Excisional Wounds in Children and Adolescents. Arch Dermatol. 2001;137:1177-1180.

8. Hollander JE, Singer AJ, Valentine S, et al. Wound registry: development and validation. Annals of Emergency Medicine. 1995;25:675-685.

9. Gennari R, Rotmensz N, Ballardini B, et al. A prospective, randomized, controlled clinical trial of tissue adhesive (2-octylcyanoacrylate) versus standard wound closure in breast surgery. Surgery. 2004;136(3):593-599.

10. Khan RJK, Fick D, Yao F, et al. A comparison of three methods of wound closure following arthroplasty. Journal of Bone and Joint Surgery. 2005;88-B(2):238-242.

11. Handschel JGK, Depprich RA, Dirksen D, et al. A prospective comparison of octyl-2-cyanoacrylate and suture in standardized facial wounds. International Journal of Oral Maxillofacial Surgery. 2006;35:318–323.

12. Scott GR, Carson CL, Borah GL. Dermabond Skin Closures for Bilateral Reduction Mammaplasties: A Review of 255 Consecutive Cases. Journal of Plastic and Reconstructive Surgery. 2007;120(6):1460-1465.

13. Nipshagen MD, Hage JJ, Beekman WH. Use of 2-Octyl Cyanoacrylate Skin Adhesive (Dermabond) for Wound Closure following Reduction Mammaplasty: A Prospective, Randomized Intervention Study. Journal of Plastic and Reconstructive Surgery. 2008;122(1):10-18.

14. Strombeck JO. Mammaplasty: Report of a new technique based on the two-pedicle procedure. Br. J. Plast. Surg. 13 79, 1960.

15. Knott PD, Zins JE, Banbury J, et al. A Comparison of Dermabond Tissue Adhesive and Sutures in the Primary Repair of the Congenital Cleft Lip. Annals of Plastic Surgery. 2007;58:121-125.

16. Krishnamoorthy B, Najam O, Khan UA, et al. Randomized Prospective Study Comparing Conventional Subcuticular Skin Closure With Dermabond Skin Glue After Saphenous Vein Harvesting. Annals of Thoracic Surgery. 2009;88:1445–50.

17. Ridgway DM, Mahmood F, Moore L, et al. A blinded, randomised, controlled trial of stapled versus tissue glue closure of neck surgery incisions. Annals of the Royal College of Surgeons of England. 2007;89:242–246.

18. Chibbaro S, Tacconi L. Use of skin glue versus traditional wound closure methods in brain surgery: A prospective, randomized, controlled study. Journal of Clinical Neuroscience. 2009;16:535–539.

19. Mattick B, Clegg G, Beattie T, et al. A randomised, controlled trial comparing a tissue adhesive (2-octylcyanoacrylate) with adhesive strips (Steristrips) for paediatric laceration repair. Emergency Medical Journal. 2002;19:405-407.

20. Shamiyeh A, Schrenk P, Stelzer T, et al. Prospective Randomized Blind Controlled Trial Comparing Sutures, Tape, and Octylcyanoacrylate Tissue Adhesive for Skin Closure After Phlebectomy. American Society for Dermatologic Surgery. 2001;27:877-880.

21. De Roos KP, Neumann HA. Muller’s ambulatory phlebectomy for varicose veins of the foot. Dermatol Surg. 1998;24:465–70.

22. Hivnor CM, Hudkins ML. Allergic Contact Dermatitis After Postsurgical Repair With 2-Octylcyanoacrylate. Arch Dermatol. 2008;144(6):814-815.

23. Edmonson B. Foreign Body Reactions to Dermabond. American Journal of Emergency Medicine. 2001;19(3):240-241.

24. Sebesta MJ, Bishoff JT. Octylcyanoacrylate skin closure in laparoscopy. Journal of Endourology. 2003;17(10):899-903.

25. King's Fund (2007). 18-Week Waiting Times Target. London: King's Fund. Available at: (accessed 26th May 2010).

26. Moy RL, Waldman B, Hein DW. A review of sutures and suturing techniques. Journal of Dermatology and Surgical Oncology. 1992;18:785-795.