Oral dryness caused by calcium blocker -Comparison with saliva of healthy elderly persons and patients with Sjögren’s syndrome-
Main Article Content
http://orcid.org/0000-0002-0699-0637
Kaoru Koide
Shuji Toya
Tomoko Nashida
Abstract
Background: In this aging society, many elderly dental patients have subjective dry mouth. The most common cause of oral dryness is the use of particular medicines, and calcium blocker is widely taken as the treatment of hypertension. The purpose of this study was to evaluate the saliva of oral dryness patients taking calcium blocker in comparison with that of the healthy elderly persons and the patients with Sjögren’s syndrome.
Methods: Forty six subjects were enrolled in this study (fifteen patients taking calcium blocker, fifteen patients with Sjögren’s syndrome, and sixteen healthy elderly persons). The unstimulated salivary flow rate was examined by ejecting gathered saliva from the mouth into a test tube for 10 min. Stimulated salivary flow rate was measured by gum-chewing with gathered saliva ejected into the test tube over a 10-min period.The total protein concentration of the saliva was determined with a protein assay kit. The differences in unstimulated salivary flow rate, protein concentration, and flow rate of protein among the three groups was analyzed with Kruskal Wallis test. The difference in stimulated saliva was analyzed with one-way analysis of variance.
Results: Unstimulated salivary flow rate and the flow rate of protein on unstimulated saliva was significantly lower on patients taking calcium blocker and patients with Sjögren’s syndrome than that on healthy elderly persons (P < 0.01). Stimulated salivary flow rate was significantly lower on patients taking calcium blocker than that on healthy elderly persons (P < 0.05), and significantly lower on patients with Sjögren’s syndrome than that on healthy elderly persons (P < 0.01).
Conclusion: The results of this study suggested that the condition of salivary gland in oral dryness patients is different from healthy elderly. Furthermore, it was considered that the submaxillary gland in patients taking calcium blocker would be affected by the calcium blocker.Article Details
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References
Hattori T, Wang PL. Calcium antagonists cause dry mouth by inhibiting resting saliva secretion. Life Sci. 2007; 81:683-690. [PubMed: 17688889]
He XJ, Wu XZ, Wellner RB, Baum BJ. Muscarinic receptor regulation of Ca2+ mobilization in a human salivary cell line. Pflugers Arch. 1989; 413:505-510. [PubMed: 2787018]
Llena-Puy C. The role of saliva in maintaining oral health and as an aid to diagnosis. Med Oral Patol Oral Cir Bucal. 2006; 11:E449-455. [PubMed: 16878065]
Márton K, Boros I, Fejérdy P, Madléna M. Evaluation of unstimulated flow rates of whole and palatal saliva in healthy patients wearing complete dentures and in patients with Sjogren's syndrome. J Prosthet Dent. 2004; 91:577-581. [PubMed: 15211301]
Mizuhashi F, Koide K, Toya S, Takahashi M, Mizuhashi R, Shimomura H. Levels of the antimicrobial proteins lactoferrin and chromogranin in the saliva of individuals with oral dryness. J Prosthet Dent. 2015; 113:35-38. [PubMed: 25300178]
Mizuhashi F, Koide K, Toya S, Nashida T. Salivary level of antimicrobial protein chromogranin A in relation to the salivary flow rate and swallowing function. Medical Research Archives. 2016; 4:1-13.
Navazesh M, Christensen CM. A comparison of whole mouth resting and stimulated salivary measurement procedures. J Dent Res. 1982; 61:1158-1162. [PubMed: 6956596]
Navazesh M, Christensen C, Brightman V. Clinical criteria for the diagnosis of salivary gland hypofunction. J Dent Res. 1992; 71:1363-1369. [PubMed: 1629451]
Orellana MF, Lagravère MO, Boychuk DG, Major PW, Flores-Mir C, Ortho C. Prevalence of xerostomia in population-based samples: a systematic review. J Public Health Dent. 2006; 66:152-158. [PubMed: 16711637]
Porter SR, Scully C, Hegarty AM. An update of the etiology and management of xerostomia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004; 97:28-46. [PubMed: 14716254]
Proctor GB. The physiology of salivary secretion. Periodontol 2000. 2016; 70:11-25. [PubMed: 26662479]
Salo T, Oikarinen KS, Oikarinen AI. Effect of phenytoin and nifedipine on collagen gene expression in human gingival fibroblasts. J Oral Pathol Med. 1990; 19:404-407. [PubMed: 2176691]
Seymour RA, Thomason JM, Nolan A. Oral lesions in organ transplant patients. J Oral Pathol Med. 1997; 26:297-304. [PubMed: 9250928]
Sreebny LM. Saliva in health and disease: an appraisal and update. Int Dent J. 2000; 50:140-161. [PubMed: 10967766]
Toljanic JA, Siddiqui AA, Patterson GL, Irwin ME. An evaluation of a dentifrice containing salivary peroxidase elements for the control of gingival disease in patients with irradiated head and neck cancer. J Prosthet Dent. 1996; 76:292-296. [PubMed: 8887803]