Helicobacter pylori infection eradication: An effective treatment to increase platelet count in patients with chronic immune thrombocytopenic purpura for at least 6 months after treatment
Main Article Content
Abstract
This before-and-after randomized clinical trial examined the impact of Helicobacter pylori elimination on the number of platelets among 23 patients (< 20 years) with chronic immune thrombocytopenic purpura (CITP). In order to detect H. pylori infections, urea breath test was performed. Based on the findings, the subjects were divided into 2 groups: uninfected (13 cases) and infected (10 cases). The groups were not significantly different regarding sex, age, anti-D treatment, history of splenectomy, or prednisolone use. None of the patients had a history of fatal diseases. Two out of 10 infected patients did not respond to H. pylori eradication treatment (resistant to treatment), while 8 patients responded to the treatment (responder group). The platelet count was assessed at baseline, as well as 3 and 6 months posttreatment. However, a steady increase was reported in the platelet count only in the responder group. A major increase was observed at 6 months after treatment versus the baseline (56.2±22.2 vs. 233±85.6 ×103/mcL; P< 0.01). Therefore, treatment was successful in CITP patients below 20 years and resulted in increased platelet count for at least 6 months.
Keywords:
13C-urea breath test, , Chronic immune thrombocytopenic purpura, Eradication therapy, Helicobacter pylori (H. pylori), Platelet count
Article Details
How to Cite
AMIRI, Mohamadreza.
Helicobacter pylori infection eradication: An effective treatment to increase platelet count in patients with chronic immune thrombocytopenic purpura for at least 6 months after treatment.
Medical Research Archives, [S.l.], v. 6, n. 1, jan. 2018.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/1653>. Date accessed: 15 dec. 2024.
doi: https://doi.org/10.18103/mra.v6i1.1653.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
References
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24.Treepongkaruna, S., Sirachainan, N., Kanjanapongkul, S., Winaichatsak, A., Sirithorn, S., Sumritsopak, R., & Chuansumrit, A. (2009). Absence of platelet recovery following Helicobacter pylori eradication in childhood chronic idiopathic thrombocytopenic purpura: A multi-center randomized controlled trial. Pediatric Blood & Cancer, 53(1), 72-77. http://dx.doi.org/10.1002/pbc.21991.
25.Vafaeimanesh, J., Hejazi, S.F. Damanpak, V., Vahedian, M., Sattari, M.A., & Seyyedmajidi, M.A. (2014). Association of Helicobacter pylori Infection with Coronary Artery Disease: Is Helicobacter pylori a Risk Factor? The Scientific World Journal, vol. 2014, Article ID 516354, 6 pages, http://dx.doi.org/10.1155/2014/516354.
26.Veres, G., Karóczkai, I., Bodánszky, H., Marosi, A., Magyarossi, E., Dezsőfi, A., & Arató, A. (2009). The role of Helicobacter pylori infection in children with chronic immune thrombocytopenic purpura. Orvosi Hetilap, 150(17), 801-804. http://dx.doi.org/10.1556/OH.2009.2858.
27.Wucherpfennig, K.W. (2001). Mechanisms for the induction of autoimmunity by infectious agents. The Journal of Clinical Investigations. 108(8): 1097–1104. doi: 10.1172/JCI14235.
2.Bonyadi, M., Ghaznavi-Rad, E., Mosayebi, G.h., Rafiei, M., Molaee, N., & Abtahi, H. (2017).Development of an arCagA Antigen-Based Assay for the Detection of Helicobacter pylori in Stool Specimens.Jundishapur Journal of
Microbiology. 10(1):e39119.DOI:10.5812/jjm.39119
3.Ciancarelli, I., Di Massimo, C., Tozzi-Ciancarelli, M., De Matteis, G., Marini, C., & Carolei, A. (2002). Helicobacter pylori infection and migraine. Cephalalgia, 22(3), 222-225. http://dx.doi.org/10.1046/j.1468-2982.2002.00354.x.
4.Emilia, G., Longo, G., Luppi, M., Gandini, G., Morselli, M., Ferrara, L., Amarri, S., Cagossi, K., & Torelli, G. (2001). Helicobacter pylorieradication can induce platelet recovery in idiopathic thrombocytopenic purpura. Blood, 97(3):812-4. doi: https://doi.org/10.1182/blood.V97.3.812.
5.Ferrara, M., Capozzi, L., & Russo, R. (2009). Effect of Helicobacter pylori eradication on platelet count in children with chronic idiopathic thrombocytopenic purpura. Hematology,14(5), 282-285. http://dx.doi.org/10.1179/102453309X12473408860181.
6.Franchini, M., Cruciani, M., Mengoli, C., Pizzolo, G., & Veneri, D. (2007). Effect of Helicobacter pylori eradication on platelet count in idiopathic thrombocytopenic purpura: a systematic review and meta-analysis.J Antimicrob Chemother .60 (2): 237-246. https://doi.org/10.1093/jac/dkm195.
7.Gasbarrini, A., Franceschi, F., Tartaglione, R., Landolfi, R., Pola, P., & Gasbarrini, G. (1998). Regression of autoimmune thrombocytopenia after eradication of Helicobacter pylori. Lancet. 12;352(9131):878. DOI: 10.1016/S0140-6736(05)60004-9.
8.Gisbert, J. P., & Pajares, J. M. (2001). Diagnosis of Helicobacter pylori infection by stool antigen determination:a systematic review. The American Journal of Gastroenterology, 96(10), 2829-2838. http://dx.doi.org/10.1111/j.1572-0241.2001.04235.x.
9.Jarque I., Andreu, R., Llopis, I., De la Rubia, J., Gomis, F., Senent, L., Jiménez, C., Martín, G., Martínez, J.A., Sanz, G.F., Ponce, J., Sanz, M.A. (2001).Absence of platelet response after eradication of Helicobacter pylori infection in patients with chronic idiopathic thrombocytopenic purpura.Br J Haematol, 115(4):1002-3.DOI: 10.1046/j.1365-2141.2001.03194.x.
10.Kohda, K., Kuga, T., Kogawa, K., Kanisawa, Y., Koike, K., Kuroiwa, G., Hirayama, Y., Sato, Y., & Niitsu, Y. ( 2002). Effect of Helicobacter pylori eradication on platelet recovery in Japanese patients with chronic idiopathic thrombocytopenic purpura and secondary autoimmune thrombocytopenic purpura. Br J Haematol. 118(2):584-8.DOI: 10.1046/j.1365-2141.2002.03612.x.
11.Lanzkowsky, Ph. (2005). Manual of pediatric hematology and oncology (5th ed.). California Elsevier: Academicpress. http://dx.doi.org/10.1016/B978-012088524-4/50006-6.
12.Maeda, S., Kanai, F., Ogura, K., Yoshida, H., Ikenoue, T., Takahashi, M., Kawabe, T., Shiratori, Y., & Omata, M. (1997).High seropositivity of anti-CagA antibody in Helicobacter pylori-infected patients irrelevant to peptic ulcers and normal mucosa in Japan.Digestive Diseases and Sciences,42(9):1841-7.DOI: 10.1023/A:1018846723379.
13.Muccio, Z., & Jackson, G. P. (2009). Isotope ratio mass spectrometry. The Analyst, 134(2), 213-222. http://dx.doi.org/10.1039/B808232D.
14.Paul Scott, J., Montgomery, R., Blanchard, S. S., & Czinn, S. J., (2007). Chronic ITP and H. Pylori eradication.In E. Behrman Richard, M. Kleigman Robert, B. Stanton, et al. (Eds.), Nelson textbook of pediatrics (19th ed., Chapters 327, 428), Philadelphia WB Saunders.
15.Pérez-Pérez, G.I., Bhat, N., Gaensbauer, J., Fraser, A., Taylor, D.N., Kuipers, E.J., Zhang, L., You, W.C., & Blaser, M.J. (1997). Country-specific constancy by age in cagA+ proportion of Helicobacter pylori infections. International Journal of Cancer, 72(3):453-6. DOI:10.1002/(SICI)1097-0215(19970729)72:3<453::AID IJC13>3.0.CO;2-D.
16. Roitt, I., Brostoff, J. & Male, D. (eds.) (1998) Immunology. Mosby International Ltd. London, UK.
17.Rostami, N., Keshtkar-Jahromi, M., Rahnavardi, M., Keshtkar-Jahromi, & M., Esfahani, F.S. (2008). Effect of eradication of Helicobacter pylori on platelet recovery in patients with chronic idiopathic thrombocytopenic purpura: a controlled trial. Am J Hematol, 83(5):376-81. DOI: 10.1002/ajh.21125.
18.Rowland, M., Bourke, B., & Drumm, B. (2004). Chapter 29. In W. A. Walker, O. Goulet, R. E. Kleinman, et al.(Eds.), pediatric gastrointestinal disease (4th ed.). USA: BCDechehr.
19.Sato, R., Murakami, K., Watanabe, K., Okimoto, T., Miyajima, H., Ogata, M., … Nasu, M. (2004). Effect of Helicobacter pylori Eradication on Platelet Recovery in Patients With Chronic Idiopathic Thrombocytopenic Purpura. Archives of Internal Medicine, 164(17), 1904. http://dx.doi.org/10.1001/archinte.164.17.1904.
20.Stasi, R., Rossi, Z., Stipa, E., Amadori, S., Newland, A.C., & Provan, D. (2005). Helicobacter pylori eradication in the management of patients with idiopathic thrombocytopenic purpura. The American Journal of Medicine, 118(4):414-9. http://dx.doi.org/10.1016/j.amjmed.2004.09.014.
21.Stasi, R., & Provan, D. (2008). Helicobacter pylori and Chronic ITP. Hematology, 2008(1), 206-211.
http://dx.doi.org/10.1182/asheducation-2008.1.206.
22.Suzuki, T.1., Matsushima, M., Masui, A., Watanabe, K., Takagi, A., Ogawa, Y., Shirai, T., & Mine T. (2005). Effect of Helicobacter pylori eradication in patients with chronic idiopathic thrombocytopenic purpura-a randomized controlled trial. Am J Gastroenterol. 100(6):1265-70. DOI: 10.1111/j.1572-0241.2005.41641.x.
23.Takahashi, T., Yujiri, T., Shinohara, K., Inoue, Y. (2003).Molecular mimicry by Helicobacter pylori CagA protein may be involved in the pathogenesis of H.pylori-associated chronic idiopathic thrombocytopenic purpura.Br J Haematol, 124 (1), 91-96.DOI: 10.1046/j.1365-2141.2003.04735.x.
24.Treepongkaruna, S., Sirachainan, N., Kanjanapongkul, S., Winaichatsak, A., Sirithorn, S., Sumritsopak, R., & Chuansumrit, A. (2009). Absence of platelet recovery following Helicobacter pylori eradication in childhood chronic idiopathic thrombocytopenic purpura: A multi-center randomized controlled trial. Pediatric Blood & Cancer, 53(1), 72-77. http://dx.doi.org/10.1002/pbc.21991.
25.Vafaeimanesh, J., Hejazi, S.F. Damanpak, V., Vahedian, M., Sattari, M.A., & Seyyedmajidi, M.A. (2014). Association of Helicobacter pylori Infection with Coronary Artery Disease: Is Helicobacter pylori a Risk Factor? The Scientific World Journal, vol. 2014, Article ID 516354, 6 pages, http://dx.doi.org/10.1155/2014/516354.
26.Veres, G., Karóczkai, I., Bodánszky, H., Marosi, A., Magyarossi, E., Dezsőfi, A., & Arató, A. (2009). The role of Helicobacter pylori infection in children with chronic immune thrombocytopenic purpura. Orvosi Hetilap, 150(17), 801-804. http://dx.doi.org/10.1556/OH.2009.2858.
27.Wucherpfennig, K.W. (2001). Mechanisms for the induction of autoimmunity by infectious agents. The Journal of Clinical Investigations. 108(8): 1097–1104. doi: 10.1172/JCI14235.