A Review – In Vitro Bile Acid Binding of Various Vegetables

Main Article Content

Talwinder Kahlon Mei-Chen M Chui Mei-Chen M Chui

Abstract

Health promoting potential (cholesterol lowering and cancer risk reduction) of various vegetables could be determined by evaluating their bile acid binding capacity.  Bile acid binding of sixteen vegetable raw (uncooked), steamed, sautéed, microwave, microwave with water and boiled were reported in six studies.  Highest bile acid binding values were observed with steaming and boiling resulted in lowest values. The Steamed vegetable would retain most of the phytonutrients.  By steaming observed bile acid bindings were for Turnips 1.2%, Green Bell Pepper and Cabbage 4%, Cauliflower, Green Beans, Carrots, Spinach, Brussels Sprouts and Broccoli 6-8%, Asparagus, Collard Greens, Mustard Greens and Kale 10-13%, Eggplant 14%, Okra 16% and Beets 18%.  Various vegetables when consumed regularly after steam cooking, combined with low fat diet would result in potential lower risk of premature degenerative diseases (heart disease and cancer), improve public health and advance human nutrition research.

Keywords: bile acid binding, vegetables, steaming, sauteing, microwave, boiling

Article Details

How to Cite
KAHLON, Talwinder; CHUI, Mei-Chen M; CHUI, Mei-Chen M. A Review – In Vitro Bile Acid Binding of Various Vegetables. Medical Research Archives, [S.l.], v. 6, n. 2, feb. 2018. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/1686>. Date accessed: 26 dec. 2024. doi: https://doi.org/10.18103/mra.v6i2.1686.
Section
Review Articles

References

[1]. Mathers CD, Lopez AD, Murray CJL. “The Burden of Disease and Mortality by Condition: Data, Methods, and Results for 2001.” In Global Burden of Disease and Risk Factors, eds. Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJL. New York: Oxford University Press.
[2]. Hofmann AF. 1977. The enterohepatic circulation of bile acids in man. Clin
Gastroenterol. 6, 3-24.
[3]. Hageman J, Herrema H, Groen AK, Kuipers F. 2010. A role of bile salt receptor FXR in atherosclerosis. Athero. Throm. And Vascular Biol. 30, 1519-1528.
[4]. Trowell HC. In: Burkitt, Trowell, editors. 1975. Refined foods and disease. London: Academic Press; p. 195-226.
[5]. Lund EK, Gee JM., Brown JC, Wood PJ, Johnson IT. 1989. Effect of oat gum on the physical properties of the gastrointestinal contents and on the uptake of D-galactose and cholesterol by rat small intestine in vitro. Br J Nutr 62, 91-101.
[6]. Anderson JW, Siesel AE. 1990. Hypocholesterolemic effects of oat products. In: Furda I, Brine CJ, editors. New developments in dietary fiber: physiological, physiochemical, and analytical aspects. New York: Plenum Press; p. 17-36.
[7]. Costarelli V, Key TJ, Appleby PN, Allen DS, Fentiman IS, Sanders TA. 2002. A prospective study of serum bile acid concentrations and colorectal cancer risk in post-menopausal women on the island of Guernsey. Br. J. Cancer 86, 1741-1744.
[8] Suckling KE, Benson GM, Bond B, Gee A, Glen A, Haynes C, et al. 1991. Cholesterol lowering and bile acid excretion in the hamster with cholestyramine treatment. Atherosclerosis 89, 183-190.
[9]. Nakamura T, Matsuzawa Y. 1994. Drug treatment of hyperlipoproteinemia: bile acid–binding resins. Nippon Rinsho 52, 3266-3270.
[10]. Daggy BP, O'Connell NC, Jerdack GR, Stinson BA, Setchell KD. 1997. Additive hypocholesterolemic effect of psyllium and cholestyramine in the hamster: influence on fecal sterol and bile acid profiles. J. Lipid Res. 38, 491-502.
[11]. Kahlon TS, Chow FI. 2000. In vitro binding of bile acids by rice bran, oat bran, wheat bran and corn bran. Cereal Chem. 77, 518-521.
[12]. Kahlon TS, Chow FI. 2000. In vitro binding of bile acids by rice bran, oat bran, wheat bran, and corn bran. Cereal Chem. 7, 518-521.
[13]. Kritchevsky D, Story JA. 1974. Binding of bile salts in vitro by nonnutritive fiber. Nutr. 104, 458-462.
[14]. Kahlon TS, Woodruff CL. 2003a. In vitro Binding of Bile Acids by Rice Bran, Oat Bran, Barley and -Glucan Enriched Barley. Cereal Chem. 80, 260-263.
[15]. Kahlon TS, Woodruff CL. 2003b. In vitro binding of bile acids by various ready to eat breakfast cereals. Cereal Foods World. 48, 73-75.
[16]. Carey MC, Small DM. 1970. The characteristics of mixed micellar solutions with particular reference to bile. Am. J. Med. 49, 590-608.
[17]. Rossi SS, Converse JL, Hoffman AF. 1987. High pressure liquid chromatography analysis of conjugated bile acids in human bile: Simultaneous resolution of sulfated and unsulfated lithocholyl amidates and the common conjugated bile acids. J. Lipid Res. 28: 589-595.
[18]. Kahlon TS, Chapman MH, Smith GE. 2007a. In vitro binding of bile acids by spinach, kale, brussels sprouts, broccoli, mustard greens, green bell pepper, cabbage and collards. Food Chemistry 100: 1531–1536.
[19] Kahlon TS, Chapman MH, Smith GE. 2007b. In vitro binding of bile acids by okra, beets, asparagus, eggplant, turnips, green beans, carrots and cauliflower. Food Chemistry 103:676-680.
[20] Kahlon TS, Chiu MM, Chapman MH. 2007c. Steam cooking significantly improves in vitro bile acid binding of beets, eggplant, asparagus, carrots, green beans and cauliflower. Nutrition Research 27:750-755.
[21] Kahlon TS, Chiu MM, Chapman MH. 2008. Steam cooking significantly improves in vitro bile acid binding of collard greens, kale, mustard greens, broccoli, green bell pepper and cabbage. Nutrition Research 28:351-357.
[22] Kahlon T, Milczarek RR, Chiu MM. 2012a. In vitro bile acid binding of mustard greens, kale, broccoli, cabbage and green bell pepper improves with sautéing compared with raw or other methods of preparation. Food and Nutrition Sciences 3:951-958.
[23] Kahlon TS, Milczarek RR, Chiu MM. 2012b. In vitro bile acid binding of kale, mustard greens, broccoli, cabbage and green bell pepper improves with microwave cooking. Vegetos 25:29-36.
[24] Gregor M. 2014. Which Vegetable Binds Bile Best? Michael Greger M.D. FACLM August 6th, Volume 20 https://nutritionfacts.org/video/which-vegetable-binds-bile-best/.