In vivo Near Infrared Spectroscopy: a novel approach for simultaneously estimating molecules and hemodynamic parameters in the human and rat brain: a review
Main Article Content
Abstract
There have been great advances in optical brain imaging over the last 50 years and the technique has grown into a richly diverse field. In vivo recording and imaging using light provides extraordinary sensitivity to functional changes through intrinsic contrast, blood, and can even exploit the growing availability of exogenous optical contrast agents. Light can be used to analyze microscopic structures and function in vivo in the exposed animal brain, while also allowing noninvasive imaging of hemodynamics and metabolism in a clinical setting. This review is an overview of approaches that have been applied in vivo optical brain recording, in both animals and humans. The basic principles of each technique are described, emphasizing the techniques used in our laboratory.
Techniques include imaging of exposed cortex, in vivo functional spectroscopy of the living brain using optic fibers, and the broad range of noninvasive topography and tomography approaches to near-infrared imaging of the human brain. The basic principles of each technique are described, followed by examples of current applications to cutting-edge neuroscience research. In summary, it is shown that optical brain recording continues to grow and evolve, embracing new technologies and advancing to address ever more complex and important neuroscientific questions.
Keywords:
Spectroscopy, optical imaging, two-photon microscopy, near-infrared spectroscopy, diffuse optical tomography, neuroimaging, neurovascular coupling
Article Details
How to Cite
GONZÁLEZ-MORA, José Luis et al.
In vivo Near Infrared Spectroscopy: a novel approach for simultaneously estimating molecules and hemodynamic parameters in the human and rat brain: a review.
Medical Research Archives, [S.l.], v. 6, n. 2, feb. 2018.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/1696>. Date accessed: 26 dec. 2024.
doi: https://doi.org/10.18103/mra.v6i2.1696.
Section
Review Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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15. Hernández SE, Rodríguez VD, Pérez J, Martín FA, Castellano MA, Gonzalez-Mora JL. Diffuse reflectance spectroscopy characterization of hemoglobin and intralipid solutions: in vitro measurements with continuous variation of absorption and scattering. J Biomed Opt. 2009;14(3):34026.
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17. Martín FA, Rojas-Díaz D, Morales CA, Camacho J, González–Mora JL, Castellano MA. Simultaneous In Vivo Measurements of Methemoglobin and Other Endogenous Chromophores by Visible Spectroscopy.
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20. Felipe A. Martin Simeona J. Alonso, Eduardo Navarro, Miguel A JLG-M. Fiber optic spectroscopy to study neurovascular coupling in small areas of the rat brain. In: Progress in Optical Fibers Research. 2007. p. 369–89.
21. Feelisch M Werringloer J KD. The oxyhemoglobin assay. In: Methods in nitric oxide research. 1996. p. 455–78.
22. Martín FA, Rojas-Díaz D, Luis-García ML, González-Mora JL, Castellano MA. Simultaneous monitoring of nitric oxide, oxyhemoglobin and deoxyhemoglobin from small areas of the rat brain by in vivo visible spectroscopy and a least-square approach. J Neurosci Methods. 2004;140(1):75–80.
23. Espinosa N, Cudeiro J, Mariño J. Spectroscopic measurement of cortical nitric oxide release induced by ascending activation. Neuroscience. 2015;285:303–11.
24. de Labra C. Different sources of nitric oxide mediate neurovascular coupling in the lateral geniculate nucleus of the cat. Front Syst Neurosci [Internet]. 2009;3(September):2–3. Available from: http://journal.frontiersin.org/article/10.3389/neuro.06.009.2009/abstract
25. Hyde DC, Boas DA, Blair C, Carey S. Near-infrared spectroscopy shows right parietal specialization for number in pre-verbal infants. Neuroimage [Internet]. 2010;53(2):647–52. Available from: http://www.sciencedirect.com/science/article/pii/S1053811910008748
26. Okada F, Tokumitsu Y, Hoshi Y, Tamura M. Impaired interhemispheric integration in brain oxygenation and hemodynamics in schizophrenia. Eur Arch Psychiatry Clin Neurosci [Internet]. 1994;244(1):17–25. Available from: http://dx.doi.org/10.1007/BF02279807
27. Ferrari M, Quaresima V. A brief review on the history of human functional near-infrared spectroscopy (fNIRS) development and fields of application. Neuroimage. 2012;63(2):921–35.
28. Afergan DA. Implicit Brain-Computer Interfaces for Adaptive Systems: Improving Performance through Physiological Sensing. Tufts University; 2015.
29. Kirilina E, Jelzow A, Heine A, Niessing M, Wabnitz H, Brühl R, et al. The physiological origin of task-evoked systemic artefacts in functional near infrared spectroscopy. Neuroimage. 2012;61(1):70–81.
30. Saager R, Berger A. Measurement of layer-like hemodynamic trends in scalp and cortex: implications for physiological baseline suppression in functional near-infrared spectroscopy. J Biomed Opt. 2008;13(3):10.
31. Turkeltaub PE, Coslett HB. Localization of sublexical speech perception components. Brain Lang. 2010;114(1):1–15.
32. Yang J, Andric M, Mathew MM. The neural basis of hand gesture comprehension: a meta-analysis of functional magnetic resonance imaging studies. Neurosci Biobehav Rev. 2015;57:88–104.
33. Samara Z, Evers EAT, Goulas A, Uylings HBM, Rajkowska G, Ramaekers JG, et al. Human orbital and anterior medial prefrontal cortex: Intrinsic connectivity parcellation and functional organization. Brain Struct Funct. 2017;1–20.
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