Negative Pressure Wound Therapy: Basic Science Review
Main Article Content
Abstract
Since the initial publication in 1997 of the basic research behind Negative Pressure Wound Therapy and the additional review in 2006, much additional research has been conducted. This short review highlights some of this additional basic research into the mechanisms and physiological responses to the controlled applicaiton of sub-atmospheric pressure for wound care.
Article Details
How to Cite
MORYKWAS, Michael J; MASSARY, Dominic.
Negative Pressure Wound Therapy: Basic Science Review.
Medical Research Archives, [S.l.], v. 7, n. 7, july 2019.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/1927>. Date accessed: 28 dec. 2024.
doi: https://doi.org/10.18103/mra.v7i7.1927.
Section
Review Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
References
1. Argenta, L.C. and M.J. Morykwas, Vacuum-assisted closure: a new method for wound control and treatment: clinical experience. Ann Plast Surg, 1997. 38(6): p. 563-76; discussion 577.
2. Morykwas, M.J., et al., Vacuum-assisted closure: state of basic research and physiologic foundation. Plast Reconstr Surg, 2006. 117(7 Suppl): p. 121S-126S.
3. Morykwas, M.J., et al., Vacuum-assisted closure: a new method for wound control and treatment: animal studies and basic foundation. Ann Plast Surg, 1997. 38(6): p. 553-62.
4. Assadian, O., et al., Bacterial growth kinetic without the influence of the immune system using vacuum-assisted closure dressing with and without negative pressure in an in vitro wound model. Int Wound J, 2010. 7(4): p. 283-9.
5. Boone, D., et al., Bacterial burden and wound outcomes as influenced by negative pressure wound therapy . Wounds, 2010. 22(2): p. 32-7.
6. Liu, D., et al., Negative-pressure wound therapy enhances local inflammatory responses in acute infected soft-tissue wound. Cell Biochem Biophys, 2014. 70(1): p. 539-47.
7. Zhou, M., et al., Role of different negative pressure values in the process of infected wounds treated by vacuum-assisted closure: an experimental study. Int Wound J, 2013. 10(5): p. 508-15.
8. Tahir, S., et al., The Effect of Negative Pressure Wound Therapy with and without Instillation on Mature Biofilms In Vitro. Materials (Basel), 2018. 11(5).
9. Matiasek, J., et al., The effect of negative pressure wound therapy with antibacterial dressings or antiseptics on an in vitro wound model. J Wound Care, 2017. 26(5): p. 236-242.
10. Motiei, M., et al., Gold nanoparticles for tracking bacteria clearance by regulated irrigation and negative pressure-assisted wound therapy. Nanomedicine (Lond), 2018. 13(15): p. 1835-1945.
11. Guoqi, W., et al., Negative pressure wound therapy reduces the motility of Pseudomonas aeruginosa and enhances wound healing in a rabbit ear biofilm infection model. Antonie Van Leeuwenhoek, 2018. 111(9): p. 1557-1570.
12. Liu, D., et al., Virulence analysis of Staphylococcus aureus in a rabbit model of infected full-thickness wound under negative pressure wound therapy. Antonie Van Leeuwenhoek, 2018. 111(2): p. 161-170.
13. Ludolph, I., et al., Negative pressure wound treatment with computer-controlled irrigation/instillation decreases bacterial load in contaminated wounds and facilitates wound closure. Int Wound J, 2018. 15(6): p. 978-984.
14. Moues, C.M., et al., Bacterial load in relation to vacuum-assisted closure wound therapy: a prospective randomized trial. Wound Repair Regen, 2004. 12(1): p. 11-7.
15. Weed, T., C. Ratliff, and D.B. Drake, Quantifying bacterial bioburden during negative pressure wound therapy: does the wound VAC enhance bacterial clearance? Ann Plast Surg, 2004. 52(3): p. 276-9; discussion 279-80.
16. Wagner, S., et al., Comparison of inflammatory and systemic sources of growth factors in acute and chronic human wounds. Wound Repair Regen, 2003. 11(4): p. 253-60.
17. Lindstedt, S., et al., Topical negative pressure effects on coronary blood flow in a sternal wound model. Int Wound J, 2008. 5(4): p. 503-9.
18. Borgquist, O., et al., Measurements of wound edge microvascular blood flow during negative pressure wound therapy using thermodiffusion and transcutaneous and invasive laser Doppler velocimetry. Wound Repair Regen, 2011. 19(6): p. 727-33.
19. Innocenti, M., et al., Effects of Cutaneous Negative Pressure Application on Perforator Artery Flow in Healthy Volunteers: A Preliminary Study. J Reconstr Microsurg, 2019. 35(3): p. 189-193.
20. Sogorski, A., et al., Improvement of local microcirculation through intermittent Negative Pressure Wound Therapy (NPWT). J Tissue Viability, 2018. 27(4): p. 267-273.
21. Sundby, Ø., et al., Intermittent negative pressure applied to the lower limb increases foot macrocirculatory and microcirculatory blood flow pulsatility in people with spinal cord injury. Spinal Cord, 2018. 56(4): p. 382-391.
22. Sundby, Ø., et al., The acute effects of lower limb intermittent negative pressure on foot macro- and microcirculation in patients with peripheral arterial disease. PLoS One, 2017. 12(6): p. e0179001.
23. Kairinos, N., et al., The flaws of laser Doppler in negative-pressure wound therapy research. Wound Repair Regen, 2014. 22(3): p. 424-9.
24. Jung, J.A., et al., Influence of Negative-Pressure Wound Therapy on Tissue Oxygenation in Diabetic Feet. Adv Skin Wound Care, 2016. 29(8): p. 364-70.
25. Nolff, M., et al., Histomorphometric evaluation of MMP-9 and CD31 expression during healing under Negative Pressure Wound Therapy in dogs. Schweiz Arch Tierheilkd, 2018. 160(9): p. 525-532.
26. Pawar, D.R.L., et al., Influence of negative pressure wound therapy on peri-prosthetic tissue vascularization and inflammation around porous titanium percutaneous devices. J Biomed Mater Res B Appl Biomater, 2019.
27. Chen, X.J., et al., Effects of vacuum sealing drainage on the treatment of cranial bone-exposed wounds in rabbits. Braz J Med Biol Res, 2017. 50(12): p. e5837.
28. Chen, D., et al., Circulating fibrocyte mobilization in negative pressure wound therapy. J Cell Mol Med, 2017. 21(8): p. 1513-1522.
29. Tanaka, T., et al., Negative pressure wound therapy induces early wound healing by increased and accelerated expression of vascular endothelial growth factor receptors. Eur J Plast Surg, 2016. 39: p. 247-256.
30. Yang, S.L., et al., Effect of Negative Pressure Wound Therapy on Cellular Fibronectin and Transforming Growth Factor-β1 Expression in Diabetic Foot Wounds. Foot Ankle Int, 2017. 38(8): p. 893-900.
31. Karam, R.A., et al., Effect of negative pressure wound therapy on molecular markers in diabetic foot ulcers. Gene, 2018. 667: p. 56-61.
32. Borys, S., et al., Negative pressure wound therapy in the treatment of diabetic foot ulcers may be mediated through differential gene expression. Acta Diabetol, 2019. 56(1): p. 115-120.
33. Wang, T., et al., Negative pressure wound therapy inhibits inflammation and upregulates activating transcription factor-3 and downregulates nuclear factor-κB in diabetic patients with foot ulcerations. Diabetes Metab Res Rev, 2017. 33(4).
34. Dwivedi, M.K., et al., Expression of MMP-8 in Pressure Injuries in Spinal Cord Injury Patients Managed by Negative Pressure Wound Therapy or Conventional Wound Care: A Randomized Controlled Trial. J Wound Ostomy Continence Nurs, 2017. 44(4): p. 343-349.
35. Shou, K., et al., Enhancement of Bone-Marrow-Derived Mesenchymal Stem Cell Angiogenic Capacity by NPWT for a Combinatorial Therapy to Promote Wound Healing with Large Defect. Biomed Res Int, 2017. 2017: p. 7920265.
36. Huang, C.H., et al., Negative pressure induces p120-catenin-dependent adherens junction disassembly in keratinocytes during wound healing. Biochim Biophys Acta, 2016. 1863(9): p. 2212-20.
2. Morykwas, M.J., et al., Vacuum-assisted closure: state of basic research and physiologic foundation. Plast Reconstr Surg, 2006. 117(7 Suppl): p. 121S-126S.
3. Morykwas, M.J., et al., Vacuum-assisted closure: a new method for wound control and treatment: animal studies and basic foundation. Ann Plast Surg, 1997. 38(6): p. 553-62.
4. Assadian, O., et al., Bacterial growth kinetic without the influence of the immune system using vacuum-assisted closure dressing with and without negative pressure in an in vitro wound model. Int Wound J, 2010. 7(4): p. 283-9.
5. Boone, D., et al., Bacterial burden and wound outcomes as influenced by negative pressure wound therapy . Wounds, 2010. 22(2): p. 32-7.
6. Liu, D., et al., Negative-pressure wound therapy enhances local inflammatory responses in acute infected soft-tissue wound. Cell Biochem Biophys, 2014. 70(1): p. 539-47.
7. Zhou, M., et al., Role of different negative pressure values in the process of infected wounds treated by vacuum-assisted closure: an experimental study. Int Wound J, 2013. 10(5): p. 508-15.
8. Tahir, S., et al., The Effect of Negative Pressure Wound Therapy with and without Instillation on Mature Biofilms In Vitro. Materials (Basel), 2018. 11(5).
9. Matiasek, J., et al., The effect of negative pressure wound therapy with antibacterial dressings or antiseptics on an in vitro wound model. J Wound Care, 2017. 26(5): p. 236-242.
10. Motiei, M., et al., Gold nanoparticles for tracking bacteria clearance by regulated irrigation and negative pressure-assisted wound therapy. Nanomedicine (Lond), 2018. 13(15): p. 1835-1945.
11. Guoqi, W., et al., Negative pressure wound therapy reduces the motility of Pseudomonas aeruginosa and enhances wound healing in a rabbit ear biofilm infection model. Antonie Van Leeuwenhoek, 2018. 111(9): p. 1557-1570.
12. Liu, D., et al., Virulence analysis of Staphylococcus aureus in a rabbit model of infected full-thickness wound under negative pressure wound therapy. Antonie Van Leeuwenhoek, 2018. 111(2): p. 161-170.
13. Ludolph, I., et al., Negative pressure wound treatment with computer-controlled irrigation/instillation decreases bacterial load in contaminated wounds and facilitates wound closure. Int Wound J, 2018. 15(6): p. 978-984.
14. Moues, C.M., et al., Bacterial load in relation to vacuum-assisted closure wound therapy: a prospective randomized trial. Wound Repair Regen, 2004. 12(1): p. 11-7.
15. Weed, T., C. Ratliff, and D.B. Drake, Quantifying bacterial bioburden during negative pressure wound therapy: does the wound VAC enhance bacterial clearance? Ann Plast Surg, 2004. 52(3): p. 276-9; discussion 279-80.
16. Wagner, S., et al., Comparison of inflammatory and systemic sources of growth factors in acute and chronic human wounds. Wound Repair Regen, 2003. 11(4): p. 253-60.
17. Lindstedt, S., et al., Topical negative pressure effects on coronary blood flow in a sternal wound model. Int Wound J, 2008. 5(4): p. 503-9.
18. Borgquist, O., et al., Measurements of wound edge microvascular blood flow during negative pressure wound therapy using thermodiffusion and transcutaneous and invasive laser Doppler velocimetry. Wound Repair Regen, 2011. 19(6): p. 727-33.
19. Innocenti, M., et al., Effects of Cutaneous Negative Pressure Application on Perforator Artery Flow in Healthy Volunteers: A Preliminary Study. J Reconstr Microsurg, 2019. 35(3): p. 189-193.
20. Sogorski, A., et al., Improvement of local microcirculation through intermittent Negative Pressure Wound Therapy (NPWT). J Tissue Viability, 2018. 27(4): p. 267-273.
21. Sundby, Ø., et al., Intermittent negative pressure applied to the lower limb increases foot macrocirculatory and microcirculatory blood flow pulsatility in people with spinal cord injury. Spinal Cord, 2018. 56(4): p. 382-391.
22. Sundby, Ø., et al., The acute effects of lower limb intermittent negative pressure on foot macro- and microcirculation in patients with peripheral arterial disease. PLoS One, 2017. 12(6): p. e0179001.
23. Kairinos, N., et al., The flaws of laser Doppler in negative-pressure wound therapy research. Wound Repair Regen, 2014. 22(3): p. 424-9.
24. Jung, J.A., et al., Influence of Negative-Pressure Wound Therapy on Tissue Oxygenation in Diabetic Feet. Adv Skin Wound Care, 2016. 29(8): p. 364-70.
25. Nolff, M., et al., Histomorphometric evaluation of MMP-9 and CD31 expression during healing under Negative Pressure Wound Therapy in dogs. Schweiz Arch Tierheilkd, 2018. 160(9): p. 525-532.
26. Pawar, D.R.L., et al., Influence of negative pressure wound therapy on peri-prosthetic tissue vascularization and inflammation around porous titanium percutaneous devices. J Biomed Mater Res B Appl Biomater, 2019.
27. Chen, X.J., et al., Effects of vacuum sealing drainage on the treatment of cranial bone-exposed wounds in rabbits. Braz J Med Biol Res, 2017. 50(12): p. e5837.
28. Chen, D., et al., Circulating fibrocyte mobilization in negative pressure wound therapy. J Cell Mol Med, 2017. 21(8): p. 1513-1522.
29. Tanaka, T., et al., Negative pressure wound therapy induces early wound healing by increased and accelerated expression of vascular endothelial growth factor receptors. Eur J Plast Surg, 2016. 39: p. 247-256.
30. Yang, S.L., et al., Effect of Negative Pressure Wound Therapy on Cellular Fibronectin and Transforming Growth Factor-β1 Expression in Diabetic Foot Wounds. Foot Ankle Int, 2017. 38(8): p. 893-900.
31. Karam, R.A., et al., Effect of negative pressure wound therapy on molecular markers in diabetic foot ulcers. Gene, 2018. 667: p. 56-61.
32. Borys, S., et al., Negative pressure wound therapy in the treatment of diabetic foot ulcers may be mediated through differential gene expression. Acta Diabetol, 2019. 56(1): p. 115-120.
33. Wang, T., et al., Negative pressure wound therapy inhibits inflammation and upregulates activating transcription factor-3 and downregulates nuclear factor-κB in diabetic patients with foot ulcerations. Diabetes Metab Res Rev, 2017. 33(4).
34. Dwivedi, M.K., et al., Expression of MMP-8 in Pressure Injuries in Spinal Cord Injury Patients Managed by Negative Pressure Wound Therapy or Conventional Wound Care: A Randomized Controlled Trial. J Wound Ostomy Continence Nurs, 2017. 44(4): p. 343-349.
35. Shou, K., et al., Enhancement of Bone-Marrow-Derived Mesenchymal Stem Cell Angiogenic Capacity by NPWT for a Combinatorial Therapy to Promote Wound Healing with Large Defect. Biomed Res Int, 2017. 2017: p. 7920265.
36. Huang, C.H., et al., Negative pressure induces p120-catenin-dependent adherens junction disassembly in keratinocytes during wound healing. Biochim Biophys Acta, 2016. 1863(9): p. 2212-20.