Surgical Management of Incidental Appendiceal Paraganglioma A Rare Case Report and Review of Literature

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Andrew Scott Brown Pamela McCloskey Andrea Matson Raul Lopez


We report a case of paraganglioma of the appendix in a 78-year-old male who presented with right upper quadrant pain, gallstones, and nausea.  To the best of these author’s knowledge, this is the one of the first cases of a pure paraganglioma of the appendix reported in the literature.  The rarity of this disease makes it difficult to isolate clear predictors of malignancy. Lifelong follow up in patients with chromaffin cell tumors is mandatory.  Immunohistochemical analysis is considered a crucial step in diagnosis of paraganglioma.  These tumors stain positive for a wide variety of markers including synaptophysin, chromogranin, and S100, along with demonstrating a low nucleus to cytoplasm ratio. We do believe that an accurate diagnosis of paraganglioma of appendix was rendered.

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BROWN, Andrew Scott et al. Surgical Management of Incidental Appendiceal Paraganglioma. Medical Research Archives, [S.l.], v. 7, n. 7, july 2019. ISSN 2375-1924. Available at: <>. Date accessed: 25 oct. 2021. doi:
Case Reports


1. van Eeden, Offerhaus, Peterse, Dingemans and G Blaauwgeers. Gangliocytic paraganglioma of the appendix. Histopathology. 2000;36(1):47-49.

2. Abdelbaqi M, Tahmasbi M, Ghayouri M. Gangliocytic paraganglioma of the appendix with features suggestive of malignancy, a rare case report and review of the literature. Internal Journal of Clinical Exp Pathology. 2013;6(9):1948-1952.

3. Tischler A, deKrijger R. 15 YEARS OF PARAGANGLIOMA: Pathology of pheochromocytoma and paraganglioma. Endocr Relat Cancer. 2015;22(4):T123-T133.

4. Bura R. Gastric paraganglioma: case report and review of the literature. Giornale di Chirurgia – Journal of Surgery. 2017;38(2):84.

5. Westbrook K, Bridger W, Williams G. Malignant nonchromaffin paraganglioma of the stomach. The American Journal of Surgery. 1972;124(3):407-409.

6. Chrisoulidou A, Kaltsas G, Ilias I, Grossman A. The diagnosis and management of malignant phaeochromocytoma and paraganglioma. Endocr Relat Cancer. 2007;14(3):569-585.

7. Schmid C, Beham A, Steindorfer P, Auböck L, Waltner F. Non-functional malignant paraganglioma of the stomach. Virchows Archiv A Pathological Anatomy and Histopathology. 1990;417(3):261-266.

8. Laforga J, Vaquero M, Juanpere N. Paragastric paraganglioma: A case report with unusual alveolar pattern and myxoid component. Diagn Cytopathol. 2011;40(9):815-819.

9. Pickhardt P, Levy A, Rohrmann C, Kende A. Primary Neoplasms of the Appendix: Radiologic Spectrum of Disease with Pathologic Correlation. RadioGraphics. 2003;23(3):645-662.

10. Clark D, Stocks J, Wilkis J. Mesoappendiceal paraganglioma. American Journal of Gastroenterology. 1985;5(80):340-432.