Triple negative breast cancer – Understanding the clinical implications of heterogeneity
Main Article Content
Abstract
Triple negative breast cancers (TNBC) have long been associated with a worse prognosis in contrast to hormone receptor (HR) positive and human epidermal growth factor receptor 2 (HER2) positive breast tumours. However, advances in the classification and molecular categorization of TNBC have led to meaningful advances, highlighting substantial TNBC heterogeneity and distinct histomolecular subtypes. While TNBC has historically been treated with single or combined chemotherapeutic agents, novel targeted therapies are being developed and evaluated. A better understanding of oncogenic drivers and the pathogenicity of germline and somatic mutations has also paved the way to new targeted treatments. More recently, the neoadjuvant space has become increasingly popular to better understand the behaviour of TNBC subtypes, leading to the development of biomarker-driven trials to better select targeted treatments. This has ultimately led to a number of advances and new potential targets for treatment which remain under investigation and will undoubtedly lead to a better understanding and personalized approach for patients diagnosed with TNBC.
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How to Cite
KAREN, Gelmon; N, LeVasseur.
Triple negative breast cancer – Understanding the clinical implications of heterogeneity.
Medical Research Archives, [S.l.], v. 8, n. 3, mar. 2020.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/2037>. Date accessed: 22 dec. 2024.
doi: https://doi.org/10.18103/mra.v8i3.2037.
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Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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