Prognostic utility of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio for cancer patients with brain metastasis

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Bernardo Cacho-Díaz, Dr. Héctor Spínola-Maroño, Dr. Javier Mexi Yaotzin Prado-Peredo Karen Salmerón-Moreno, Dr. Laura Georgina Mendoza-Olivas Myrna Candelaria-Hernández, Dr. Ytel Jazmin Garcilazo-Reyes, Dr.


This study aims to determine the utility of the neutrophil-to-lymphocyte-ratio (NLR) and platelet-to-lymphocyte-ratio (PLR) as prognostic markers for brain metastasis (BM). Employing NLR cutoff values at BM diagnosis, 550 patients were divided into groups I-III (I:<3, II: 3–4.49, III: >4.5), and median overall survival (MOS) was calculated (I: 20 months, II: 13.9 months, and III: 7.5 months). Groups divided by a PLR cutoff (I:250, II:≥250 also differed in MOS (13.9 vs. 9.3 months). After multivariable analysis, only NLR was a significant independent predictor of MOS [I vs. II: 1.5 Hazard Ratio (HR); I vs. III: 1.9 HR].

Keywords: survival, prognosis, platelet-to-lymphocyte ratio, brain metastasis

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CACHO-DÍAZ, Bernardo et al. Prognostic utility of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio for cancer patients with brain metastasis. Medical Research Archives, [S.l.], v. 8, n. 5, may 2020. ISSN 2375-1924. Available at: <>. Date accessed: 25 mar. 2023. doi:
Research Articles


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