The cardiovascular implications of COVID-19: A Comprehensive Review 

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Shumail Fatima Syed Bukhari John Pacella


The coronavirus disease of 2019 (COVID-19) is a global medical crisis that has posed immense challenges to the medical fraternity worldwide. COVID-19 is caused by Severe Acute Respiratory Syndrome - Corona Virus - 2 (SARS-CoV-2) that targets the host’s Angiotensin Converting Enzyme -2 (ACE2) receptors present in the lungs, heart, blood vessels, kidneys and intestines. Symptoms are primarily respiratory in origin but the disease has the propensity to involve all organ systems quickly to cause multi-organ failure and death. The patients with pre-existing cardiovascular diseases are more prone to contracting infection, and the involvement of cardiovascular system itself has been linked to increased morbidity and mortality in COVID-19 patients. Therefore, learning about the cardiovascular implications of SARS-CoV-2 infection is of paramount importance for the cardiology world at this juncture. Herein, we review the initial literature relevant to SARS-CoV-2 associated cardiovascular pathology, highlighting cardiac manifestations, biomarker utility and therapeutic landscape in the present era of COVID-19. 


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FATIMA, Shumail; BUKHARI, Syed; PACELLA, John. The cardiovascular implications of COVID-19: A Comprehensive Review . Medical Research Archives, [S.l.], v. 8, n. 5, may 2020. ISSN 2375-1924. Available at: <>. Date accessed: 29 jan. 2023. doi:
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