Insulin-Like Growth Factor I (IGF-I); cytoprotective effects, idea of replacement therapy in the healthy elderly subjects
Main Article Content
Abstract
Insulin-like growth factor-I (IGF-I) is one of the important molecule that has driven great interest in gerontology. The connection between IGF-I and the replacement therapy has been the center for many investigations for the past decade. IGF-I levels decline with age and has been considered to contribute to age-related decline in body activities. As adults age, there is a decline in the concentration of IGF-I. It has been postulated that the declines in both growth hormone (GH) and IGF-I, as it is evident in aged adults, may be associated with increased body fat, reduced muscle strength, decreased bone mass, and reduced lean body mass. This reduction may lead to overall body performance and thus may decrease the quality of life. In the present review, we have viewed the past history of the relevant publications to find a perception that would lead us to come close to the idea of the therapeutic step and provide a view of a possible IGF-I replacement therapy in the healthy elderly subjects. More specifically, this review will summarize and help to understand the effects and benefits of IGF-I system impacting on the aged organ systems. In addition, we aim to discuss the general functional properties of IGF-I and implications of its possible use as a replacement to the healthy elderly subjects and we will emphasis its downfalls and new perceptions.
Article Details
How to Cite
DALCIK, Hakki; DALCIK, Cannur.
Insulin-Like Growth Factor I (IGF-I); cytoprotective effects, idea of replacement therapy in the healthy elderly subjects.
Medical Research Archives, [S.l.], v. 8, n. 6, june 2020.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/2154>. Date accessed: 20 apr. 2024.
doi: https://doi.org/10.18103/mra.v8i6.2154.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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3. Rotwein P. Molecular biology of IGF-I and IGF-II. In: Rosenfeld RG, Roberts Jr CT, eds. The IGF system: molecular biology, physiology and clinical applications, 17th ed. Totowa, NJ: Humana Press. 1999;19-36
4. LeRoith D. Insulin-like growth factors. N Engl J Med. 1997;336:633-640
5. Yakar S, Liu JL, Stannard B, Butler A, Accili D, Sauer B, LeRoith D. Normal growth and development in the absence of hepatic insulin-like growth factor-I. Proc Natl Acad Sci USA. 1999;96:7324-7329
6. Bright GM, Fierro-Renoy JF. A rationale fort he treatment of short stature in children with the combonation of recombonant human growth hormone (rhGH) and recombinant human insulin-like growth factor-I (rhIGF-I). Growth Horm IGF Res. 2020;52:101318-101325
7. Sun LY, Al-Regaiey K, Mastemak MM, Wang J, Bartke A. Local expression of GH and IGF-1 in the hippocampus of GH-deficient long-lived mice. Neurobiol Aging. 2005;26(6):929-37
8. Murphy LJ, Friesen HG. Differential effects of estrogen and growth hormone on uterine and hepatic insulin-like growth factor I gene expression in the ovariectomized hypophysectomized rat. Endocrinol. 1988;122:325-332
9. Hofbauer LC, Rafferzeder M, Janssen OE, Gartner R. Insulin-like growth factor-I messenger ribonucleic acid expression in porcine thyroid follicles is regulated by thyrotropin and iodine. Eur J Endocrinol. 1995;132:605-610
10. Clemmons DR. Insulin-like growth factor binding proteins and their role in controlling IGF actions. Cytokine Growth Factor Rev. 1997;8:45-62
11. Ranke MB, Elmlinger M. Functional role of the insulin-like growth factor binding proteins. Horm Res. 1997;48:9-15
12. Collett-Solberg PF, Cohen P. Genetics, chemistry, and function of the IGF/IGFBP system. Endocrine. 2000;12:121-136
13. Firth SM, McDougall F, McLachlan AJ, Baxter RC. Impaired blockade of insulin-like growth factor I (IGF-I)-induced hypoglycemia by IGF binding protein-3 analog with reduced ternary complex-forming ability. Endocrinology. 2002;143:1669-1676
14. Mohan S, Baylink DJ. IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms. J Endocrinol. 2002;175:19-31
15. Baxter RC. Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities. Am J Physiol Endocrinol Metab. 2000;278:E967–E976
16. Butler AA, Yakar S, Gewolb IH, Karas M, Okubo Y, LeRoith D. Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology. Comp Biochem Physiol Biochem Mol Biol. 1998;121:19-26
17. Lowe Jr WL, Adamo M, Werner H, Roberts Jr CT, LeRoith D. Regulation by fasting of insulin-like growth factor-I and its receptor: effects on gene expression and binding. J Clin Invest. 1989;84:619-626
18. Werner H, Roberts Jr CT, LeRoith D. The regulation of insulin-like growth factor-I receptor gene expression by positive and negative zinc-finger transcription factors. Adv Exp Med Biol. 1993;343:91-103
19. Hernandez-Sanchez C, Werner H, Roberts Jr CT, Woo EJ, Hum DW, Rosenthal SM, LeRoith D. Differential regulation of insulin-like growth factor-I (IGF-I) receptor gene expression by IGF-I and basic fibroblastic growth factor. J Biol Chem. 1997;272:4663-4670
20. Khandwala HM, Mc Cutcheon IE, Flyvbjerg A, Friend KE. The effects of Insulin-like growth factors on tumorigenesis and neoplastic growth. Endocr Rev. 2000;21(3):215-244
21. Puche JE, Castilla-Cortazar I. Human conditions of insülin-like growth factor-I (IGF-I) deficiency. J Trans Med, 2012;10:224-253
22. Parrizas M, Saltiel A, LeRoith D. Insulin-like growth factor I inhibits apoptosis using the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways. J Biol Chem. 1997;272:154-161
23. Peruzzi F, Prisco M, Dews M, Salomoni P, Grassilli E, Romano G, Calabretta B, Baserga R. Multiple signaling pathways of the insulin-like growth factor-1 receptor in protection of apoptosis. Mol Cell Biol. 1999;19:7203-7215
24. Deng X, Ruvolo P, Carr B, May WS. Survival function of ERK 1/2 as IL-3 activated, staurosporine-resistant Bcl-2 kinases. Proc Natl Acad Sci USA. 2000;97:1578-1583
25. Hu CL, Cowan RG, Harman RM, Quirk SM. Cell cycle progression and activation of Akt kinase are required for insulin-like growth factor-I mediated suppression of apoptosis in granulosa cells. Mol. Endocrinol. 2004;18(2):326-338
26. Kasprzak A, Kwasniewski W, Adamek A, Gozdzicka-Jozefiak A. Insulin-like growth factor (IGF) axis in cancerogenesis. Mutat Res Rev Mutat Res. 2016; 772:78-104
27. Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev. 1995;16:3-34
28. Dimitriadis G, Parry-Billings M, Bevan S, Dunger D, Piva T, Krause U, Wegener G, Newsholme EA. Effects of insulin-like growth factor I on the rates of glucose transport and utilization in rat skeletal muscle in vitro. Biochem J. 1992;285:269-274
29. Dalcik C, Yildirim GK, Dalcik H. The effects of ethanol on insulin-like growth factor-I immunoreactive neurons in the central nervous system. Saudi Med J. 2009;30:179-184
30. Selles MC, Fortuna JTS, Zappa-Villar MF, de Faria YPR, Souza AS, Suemoto CK, Leite REP, Rodriguez RD, Grinberg LT, Reggiani PC, Ferreira ST. Adenovirus-mediated transduction of insulin-like growth factor 1 protects hippocampal neurons from the toxicity of Aβ oligomers and prevents memory loss in an Alzheimer Mouse model. Mol Neurobiol. 2020;57(3):1473-1483
31. Ozkan S, Vural B, Filiz S, Costur P, Dalcik H. Placental expression of insulin-like growth factor-I, fibroblast growth factor-basic, and neural cell adhesion molecule in preeclampsia. J Matern Fetal Neonatal Med. 2008;21(11):831-8
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