"Desert Chemotypes": The Potential of Desert Plants-Derived Metabolome to Become a Sustainable Resource for Drug Leads
Main Article Content
Abstract
Plants secondary metabolites that are essential for plant survival in its environment are a useful resource for drug discovery in the area of combination therapy. Desert plants, in particular, have a lot to offer; they experience stress conditions and activation/repression of pathways that lead to biosynthesis of unique compounds.
The current knowledge on the effectiveness of combination therapy as compared to single treatment support the use of active plant-derived extracts or fractions composed of several metabolites.
A set of metabolites, termed "metabolite signature", within an active fraction, will serve as a guide in the process of desert plants domestication. The combination of modern methods of transcriptome, proteome and metabolome analyses with precision agriculture, will pave the way to produce sustainable plant biomass for pharmaceutical industries.
Keywords:
plant metabolite, combined therapy, Terpenes, Flavonoids
Article Details
How to Cite
OFIR, Rivka.
"Desert Chemotypes": The Potential of Desert Plants-Derived Metabolome to Become a Sustainable Resource for Drug Leads.
Medical Research Archives, [S.l.], v. 8, n. 7, july 2020.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/2169>. Date accessed: 03 dec. 2024.
doi: https://doi.org/10.18103/mra.v8i7.2169.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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3. Veeresham C. Natural products derived from plants as a source of drugs. Journal of Advanced Pharmaceutical Technology & Research 2012;3(4):200-01.
4. Lampariello LR, Cortelazzo A, Guerranti R, Sticozzi C, Valacchi G. The Magic Velvet Bean of Mucuna pruriens. Journal of traditional and complementary medicine 2012;2(4):331-39.
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6. Hackney AC. Chapter 8 - Pharmacologic and Nutritional Substances to Enhance Performance or Produce Weight Loss. In: Hackney AC, editor. Exercise, Sport, and Bioanalytical Chemistry: Elsevier; 2016. p. 83-96.
7. Devaux CA, Rolain J-M, Colson P, Raoult D. New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? International journal of antimicrobial agents 2020:105938-38.
8. Thirumaran R, Prendergast GC, Gilman PB. Chapter 7 - Cytotoxic Chemotherapy in Clinical Treatment of Cancer. In: Prendergast GC, Jaffee EM, editors. Cancer Immunotherapy. Burlington: Academic Press; 2007. p. 101-16.
9. Coyle J, Kershaw P. Galantamine, a cholinesterase inhibitor that allosterically modulates nicotinic receptors: effects on the course of Alzheimer’s disease. Biological Psychiatry 2001;49(3):289-99.
10. Moses T, Goossens A. Plants for human health: greening biotechnology and synthetic biology. Journal of Experimental Botany 2017;68(15):4009-11.
11. Harlev E, Nevo E, Lansky EP, Lansky S, Bishayee A. Anticancer attributes of desert plants: a review. Anticancer Drugs 2012;23(3):255-71.
12. Walker KA. Inflammation and neurodegeneration: chronicity matters. Aging 2018;11(1):3-4.
13. Chitnis T, Weiner HL. CNS inflammation and neurodegeneration. The Journal of clinical investigation 2017;127(10):3577-87.
14. DeLegge MH, Smoke A. Neurodegeneration and Inflammation. Nutrition in Clinical Practice 2008;23(1):35-41.
15. Wang G, Tang W, Bidigare RR. Terpenoids As Therapeutic Drugs and Pharmaceutical Agents. In: Zhang L, Demain AL, editors. Natural Products: Drug Discovery and Therapeutic Medicine. Totowa, NJ: Humana Press; 2005. p. 197-227.
16. Cox-Georgian D, Ramadoss N, Dona C, Basu C. Therapeutic and Medicinal Uses of Terpenes. Medicinal Plants: From Farm to Pharmacy 2019:333-59.
17. Geron C, Guenther A, Greenberg J, Karl T, Rasmussen R. Biogenic volatile organic compound emissions from desert vegetation of the southwestern US. Atmospheric Environment 2006;40(9):1645-60.
18. Ibrahim MA, Mäenpää M, Hassinen V, et al. Elevation of night-time temperature increases terpenoid emissions from Betula pendula and Populus tremula. Journal of Experimental Botany 2010;61(6):1583-95.
19. Hai LL, Wen BJ, Meng XX. Flavonoids: Recent Advances as Anticancer Drugs. Recent Patents on Anti-Cancer Drug Discovery 2010;5(2):152-64.
20. Hassan AR, Amer KF, El-Toumy SA, Nielsen J, Christensen SB. A new flavonol glycoside and other flavonoids from the aerial parts of Taverniera aegyptiaca. Nat Prod Res 2019;33(8):1135-39.
21. Rauf A, Imran M, Khan IA, et al. Anticancer potential of quercetin: A comprehensive review. Phytotherapy Research 2018;32(11):2109-30.
22. Ajebli M, Eddouks M. Flavonoid-Enriched Extract from Desert Plant Warionia saharae Improves Glucose and Cholesterol Levels in Diabetic Rats. Cardiovascular & hematological agents in medicinal chemistry 2019;17(1):28-39.
23. Yoshikawa M, Xu F, Morikawa T, Ninomiya K, Matsuda H. Anastatins A and B, new skeletal flavonoids with hepatoprotective activities from the desert plant Anastatica hierochuntica. Bioorg Med Chem Lett 2003;13(6):1045-9.
24. Sak K. Anticancer effects of flavonoids on melanoma cells: are murine cells more sensitive compared to humans? 2014 2014;5(4):5.
25. Wishart DS FY, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. . DrugBank 5.0: a major update to the DrugBank database for 2018. . Nucleic Acids Res. 2017 Nov 8. doi: 10.1093/nar/gkx1037 2018.
26. Chahar MK, Sharma N, Dobhal MP, Joshi YC. Flavonoids: A versatile source of anticancer drugs. Pharmacognosy reviews 2011;5(9):1-12.
27. Wenzel U. Flavonoids as drugs at the small intestinal level. Current Opinion in Pharmacology 2013;13(6):864-68.
28. Hayat M AM, Munir F, et al. . Potential of plant flavonoids in pharmaceutics and nutraceutics. . J Biomol Biochem November-2017; 1(1): 12-17. 2017.
29. Podolak I, Galanty A, Sobolewska D. Saponins as cytotoxic agents: a review. Phytochemistry reviews : proceedings of the Phytochemical Society of Europe 2010;9(3):425-74.
30. Tian X, Tang H, Lin H, et al. Saponins: the potential chemotherapeutic agents in pursuing new anti-glioblastoma drugs. Mini Rev Med Chem 2013;13(12):1709-24.
31. Ferreira D, Gross GG, Hagerman AE, Kolodziej H, Yoshida T. Tannins and related polyphenols: perspectives on their chemistry, biology, ecological effects, and human health protection. Phytochemistry 2008;69(18):3006-8.
32. Krochmal A, Sherman P. Canaigre: A Desert Source of Tannin. Economic Botany 1951;5(4):367-77.
33. Ogawa S, Yazaki Y. Tannins from Acacia mearnsii De Wild. Bark: Tannin Determination and Biological Activities. Molecules 2018;23(4).
34. Haslam E. Natural Polyphenols (Vegetable Tannins) as Drugs: Possible Modes of Action. Journal of Natural Products 1996;59(2):205-15.
35. Mukherjee PK. Chapter 4 - Qualitative Analysis for Evaluation of Herbal Drugs. In: Mukherjee PK, editor. Quality Control and Evaluation of Herbal Drugs: Elsevier; 2019. p. 79-149.
36. Wong Paz JE, Muñiz Márquez DB, Martínez Ávila GCG, Belmares Cerda RE, Aguilar CN. Ultrasound-assisted extraction of polyphenols from native plants in the Mexican desert. Ultrasonics Sonochemistry 2015;22:474-81.
37. Najjaa H, Arfa AB, Máthé Á, Neffati M. Aromatic and Medicinal Plants of Tunisian Arid and Desert Zone Used in Traditional Medicine, for Drug Discovery and Biotechnological Applications. In: Neffati M, Najjaa H, Máthé Á, editors. Medicinal and Aromatic Plants of the World - Africa Volume 3. Dordrecht: Springer Netherlands; 2017. p. 157-230.
38. Elmann A, Mordechay S, Erlank H, et al. Anti-neuroinflammatory effects of the extract of Achillea fragrantissima. BMC complementary and alternative medicine 2011;11:98-98.
39. Elmann A, Telerman A, Mordechay S, et al. Downregulation of microglial activation by achillolide A. Planta Med 2015;81(3):215-21.
40. Elmann A, Telerman A, Mordechay S, et al. 3,5,4'-Trihydroxy-6,7,3'-trimethoxyflavone protects astrocytes against oxidative stress via interference with cell signaling and by reducing the levels of intracellular reactive oxygen species. Neurochem Int 2014;78:67-75.
41. Elmann A, Telerman A, Ofir R, Kashman Y. Glutamate Toxicity to Differentiated Neuroblastoma N2a Cells Is Prevented by the Sesquiterpene Lactone Achillolide A and the Flavonoid 3,5,4'-Trihydroxy-6,7,3'-Trimethoxyflavone from Achillea fragrantissima. J Mol Neurosci 2017;62(1):99-105.
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