Current understanding and management of positive lateral lymph nodes in rectal cancer patients
Main Article Content
Abstract
In the context of minimizing local recurrence rates after surgical treatment of rectal cancer, the issue of lateral pelvic lymph node (LPLN) dissection has remained as a controversial issue between West and East surgeons. The aim of the present paper was to review the incidence of lateral nodes, the associated risk factors and all the controversies regarding their management. While in Japan a prophylactic LPLN removal with autonomic nerve preservation (without neoadjuvancy) is considered the standard management of extra-peritoneal advanced rectal cancers, Western patients are usually treated with preoperative chemoradiotherapy (CRT) followed by total mesorectal excision. This choice is based on the effective reduction of local recurrences induced by CRT, culminating with similar outcomes when compared with LPN dissection. On the other side, this procedure is currently performed in Japan where LPN involvement is considered regional disease, so LPLN dissection is considered essential to improve outcomes. There exist suggestions that a selective approach to lateral nodes could be safely adopted in patients exhibiting radiological response after neoadjuvancy. However, others think that a more extended procedure is necessary even after CRT. Thus, the source and the risks of local recurrence must be individually assessed, and further high quality investigations must be developed to evaluate the efficacy of LPLN dissection with or without CRT.
Keywords:
rectal cancer, chemoradiation, lateral pelvic nodes, survival
Article Details
How to Cite
CAMPOS, Fábio Guilherme et al.
Current understanding and management of positive lateral lymph nodes in rectal cancer patients.
Medical Research Archives, [S.l.], v. 8, n. 8, aug. 2020.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/2199>. Date accessed: 23 nov. 2024.
doi: https://doi.org/10.18103/mra.v8i8.2199.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
References
1. Heald RJ, Moran BJ, Ryall RD, et al. Rectal cancer: the Basingstoke experience of total mesorectal excision, 1978 – 1997. Arch Surg. 1998;133:894 – 899.
2. Kodeda K, Johansson R, Zar n, et al. Time trends, improvements and national auditing of rectal cancer management over an 18-year period. Colorectal Dis. 2015;17:o168–o179.
3. Kim TG, Park W, Choi DH, Park HC, Kim SH, Cho YB, Yun SH, Kim HC, Lee WY, Lee J, Park JO, Park YS, Lim HY, Kang WK, Chun HK. Factors associated with lateral pelvic recurrence after curative resection following neoadjuvant chemoradiotherapy in rectal cancer patients. Int J Colorectal Dis. 2014 ;29(2):193-200.
4. Ueno H, Mochizuki H, Hashiguchi Y, Ishiguro M, Miyoshi M, Kajiwara Y, et al. Potential prognostic benefit of lateral pelvic node dissection for rectal cancer located below the peritoneal reflection. Ann Surg 2007;245:80-7.
5. Sato H, Maeda K, Maruta M, Masumori K, Koide Y. Who can get the beneficial effect from lateral lymph node dissection for Dukes C rectal carcinoma below the peritoneal reflection? Dis Colon Rectum 2006;49:S3-12 .
6. Villemin F, Huard P, Montagn’e M. Recherches anatomiques sur les lymphatiques du rectum et de l’anus: leur applications dans le traitement chirurgical du cancer. Rev Chir. 1925;63:39–80.
7. Sauer I, Bacon HE (1952) A new approach for excision of carcinoma of the lower portion of the rectum and anal canal. Surg Gynecol Obstet 95:229–242 .
8. Stearns MWJr, Deddish MR. Five-year results of abdominopelvic lymph node dissection for carcinoma of the rec- tum. Dis Colon Rectum 1959;2:169-172.
9. Takahashi T, Ueno M, Azekura K et al (2000) Lateral node dissection and total mesorectal excision for rectal cancer. Dis Colon Rectum 43:S59–S68 .
10. Wang Z, Loh KY, Tan KY, Woo EC (2012) The role of lateral lymph node dissection in the management of lower rectal cancer. Langenbeck's Arch Surg 397:353–361.
11. Kim JC, Takahashi K, Yu CS, et al. Comparative outcome between chemoradiotherapy and lateral pelvic lymph node dissection following total mesorectal excision in rectal cancer. Ann Surg. 2007;246(5): 754–762.
12. Kusters M, Beets GL, vandeVelde CJ et al. A comparison between the treatment of low rectal cancer in Japan and the Netherlands, focusing on the patterns of local recurrence. Ann Surg. 2009;249(2):229–235.
13. Georgiou P, Tan E, Gouvas N, Antoniou A, Brown G, Nicholls RJ, Tekkis P (2009) Extended lymphadenectomy versus conventional surgery for rectal cancer: a meta-analysis. Lancet Oncol 2009;10: 1053-1062.
14. Cheng H, Deng Z, Wang ZJ et al (2011) Lateral lymph node dissection with radical surgery versus single radical surgery for rectal cancer: a meta-analysis. Asian Pac J Cancer Prev 12:2517–2521.
15. Akiyoshi T, Watanabe T, Miyata S, Kotake K, Muto T and Sugihara K; Japanese Society for Cancer of the Colon and Rectum: Results of a Japanese nationwide multi-institutional study on lateral pelvic lymph node metastasis in low rectal cancer: Is it regional or distant disease? Ann Surg 2012; 255: 1129-1134.
16. Watanabe T, Itabashi M, Shimada Y et al. Japanese society for cancer of the colon and rectum (JSCCR) Guidelines 2014 for treatment of colorectal cancer. Int J Clin Oncol 2015; 20:207–239
17. Fujita S, Mizusawa J, Kanemitsu Y, Ito M, Kinugasa Y, Komori K, Ohue M, Ota M, Akazai Y, Shiozawa M, Yamaguchi T, Bandou H, Katsumata K, Murata K, Akagi Y, Takiguchi N, Saida Y, Nakamura K, Fukuda H, Akasu T, Moriya Y; Colorectal Cancer Study Group of Japan Clinical Oncology Group. Mesorectal Excision With or Without Lateral Lymph Node Dissection for Clinical Stage II/III Lower Rectal Cancer (JCOG0212): A Multicenter, Randomized Controlled, Noninferiority Trial. Ann Surg. 2017; 266(2):201-207.
18. Sugihara K, Kobayashi H, Kato T, et al. Indication and benefit of pelvic sidewall dissection for rectal cancer. Dis Colon Rectum. 2006; 49:1663–1672.
19. Kobayashi H, Mochizuki H, Kato T, et al. Outcomes of surgery alone for lower rectal cancer with and without pelvic sidewall dissection. Dis Colon Rectum. 2009;52:567–576.
20. Ozawa H, Kotake K, Hosaka M, Hirata A, Sigihara K. Impact of Lateral Pelvic Lymph Node Dissection on the Survival of Patients with T3 and T4 Low Rectal Cancer. World J Surg. 2016;40(6):1492-9.
21. Watanabe T, Tsurita G, Muto T, Sawada T, Sunouchi K, Higuchi Y, Komuro Y, Kanazawa T, Iijima T, Miyaki M and Nagawa H: Extended lymphadenectomy and preoperative radiotherapy for lower rectal cancers. Surgery 2002; 132: 27-33.
22. Ishihara S, Watanabe T, fukushima Y, et al. safety and factors contributing to the dificulty of laparoscopic surgery for rectal cancer treated with preoperative chemoradiotherapy. Tech Coloproctol. 2014;18:247–255.
23. Ishihara S, Kanemitsu Y, Murono K, Otani K, Koji Y, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata K, Nozawa H, Kazama S, Yamaguchi H, Sunami E, Sugihara K, Watanabe T. Oncological benefit of lateral pelvic lymph node dissection for rectal cancer treated without preoperative chemoradiotherapy: a multicenter retrospective study using propensity score analysis. Int J Colorectal Dis 2016; 31:1315–1321.
24. Ishihara S, Kawai K, tanaka T, Kiyomatsu T, Hata K, Nozawa H, Morikawa T, Watanabe T. Oncological Outcomes of Lateral Pelvic Lymph Node Metastasis in Rectal Cancer Treated With Preoperative Chemoradiotherapy . Dis Colon Rectum 2017; 60: 469–476.
25. Nagayoshi K, Ueki T, Manabe T, Moriyama T, Yanai K, Oda Y, Tanaka M. Laparoscopic lateral pelvic lymph node dissection is achievable and offers advantages as a minimally invasive surgery over the open approach. Surg Endosc 2015; 30 (5): 1938-47.
26. Watanabe T, Itabashi M, Shimada Y, Tanaka S, Ito Y, Ajioka Y, Hamaguchi T, Hyodo I, Igarashi M, Ishida H, Ishiguro M, Kanemitsu Y, Kokudo N, Muro K, Ochiai A, Oguchi M, Ohkura Y, Saito Y, Sakai Y, Ueno H, Yoshino T, Fujimori T, Koinuma N, Morita T, Nishimura G, Sakata Y, Takahashi K, Takiuchi H, Tsuruta O, Yamaguchi T, Yoshida M, Yamaguchi N, Kotake K, Sugihara K; Japanese Society for Cancer of the Colon and Rectum. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer. Int J Clin Oncol. 2012 Feb;17(1):1-29.
27. Fujita S. Incidence and prognosis of lower rectal cancer with limited extramesorectal lymph node metastasis. Int J Colorectal Dis. 2014 ; 29(9):1077-80.
28. Kim MJ, Kim TH, Kim DY, et al. Can chemoradiation allow for omission of lateral pelvic node dissection for locally advanced rectal cancer? J Surg Oncol. 2015;111:459–464.
29. Kusters M, Slater A, Muirhead R, Hompes R, Guy RJ, Jones OM, George BD, Lindsey I, Mortensen NJ, Cunningham C. What To Do With Lateral Nodal Disease in Low Locally Advanced Rectal Cancer? A Call for Further Reflection and Research. Dis Colon Rectum. 2017 ; 60(6):577-585.
30. Gleeson FC, Clain JE, Rajan E, Topazian MD, Wang KK, Levy MJ. EUS-FNA assessment of extramesenteric lymph node status in primary rectal cancer. Gastrointest Endosc. 2011;74(4):897-905
31. Shihab OC, Taylor F, Bees N, Blake H, Jeyadevan N, Bleehen R, Blomqvist L, Creagh M, George C, Guthrie A, Massouh H, Peppercorn D, Moran BJ, Heald RJ, Quirke P, Tekkis P, Brown G. MERCURY Study Group. Relevance of magnetic resonance imaging-detected pelvic sidewall lymph node involvement in rectal cancer. Br J Surg. 2011 ;98(12):1798-804.
32. Kobayashi H, Kikuchi A, Okazaki S, et al. Diagnostic performance of multidetector row computed tomography for assessment of lymph node metastasis in patients with distal rectal cancer. Ann Surg Oncol. 2015;22:203–208.
33. Ishibe A, Ota M, Watanabe J, et al. Prediction of lateral pelvic lymph-node metastasis in low rectal cancer by magnetic resonance imaging. World J Surg. 2016;40:995–1001.
34. Ogawa S, Hida JI, Ike H, Kinugasa T, Ota M, Shinto E, Itabashi M, Okamoto T, Yamamoto M, Sugihara K, Watanabe T. Prediction of lateral pelvic lymph node metastasis from lower rectal cancer using magnetic resonance imaging and risk factors for metastasis: Multicenter study of the Lymph Node Committee of the Japanese Society for Cancer of the Colon and Rectum. Int J Colorectal Dis. 2017 Oct;32(10):1479-1487.
35. Shihab OC, Taylor F, Bees N et al. Relevance of magnetic resonance imaging-detected pelvic sidewall lymph node involvement in rectal cancer. Br J Surg. 2011;98:1798–1804.
36. Nelson H, Petrelli N, Carlin A, et al. Guidelines 2000 for colon and rectal cancer surgery. J Natl Cancer Inst. 2001;93:583–596.
37. Akiyoshi T, Ueno M, Matsueda K, Konishi T, Fujimoto Y, Nagayama S, Fukunaga Y, Unno T, Kano A, Kuroyanagi H, et al: Selective lateral pelvic lymph node dissection in patients with advanced low rectal cancer treated with preoperative chemoradiotherapy based on pretreatment imaging. Ann Surg Oncol 21: 189-196, 2014.
38. Matsumoto T, Ohue M, Sekimoto M, Yamamoto H, Ikeda M, Monden M. Feasibility of autonomic nerve-preserving surgery for advanced rectal cancer based on analysis of micrometastases. Br J Surg. 2005 ;92(11):1444-8..
39. Coy CS, Meirelles LR, Leal RF et al. Evaluation of lateral lymph node metastases in advanced distal rectal cancer. Hepatogastroenterology 2010; 57:1363–1366
40. Inoue Y, Saigusa S, Hiro J, Toiyama Y, Araki T, Tanaka K, Mohri Y, Kusunoki M. Clinical significance of enlarged lateral pelvic lymph nodes before and after preoperative chemoradiotherapy for rectal cancer. Mol Clin Oncol. 2016 ;4(6):994-1002.
41. Ishihara S, Kawai K, Tanaka T, Kiyomatsu T, Hata K, Nozawa H, Morikawa T, Watanabe T. Oncological Outcomes of Lateral Pelvic Lymph Node Metastasis in Rectal Cancer Treated With Preoperative Chemoradiotherapy. Dis Colon Rectum. 2017; 60(5):469-476
42. Moriya Y, Sugihara K, Akasu T, et al. Importance of extended lymphadenectomy with lateral node dissection for advanced lower rectal cancer. World J Surg. 1997;21:728 – 732.
43. Lopez-Kostner F, Lavery IC, Hool GR, et al. Total mesorectal excision is not necessary for cancers of the upper rectum. Surgery. 1998;124:612–617.
44. Zaheer S, Pemberton JH, Farouk R, et al. Surgical treatment of adenocarcinoma of the rectum. Ann Surg. 1998;227:800–811.
45. Dharmarajan S, Shuai D, Fajardo AD, Birnbaum EH, Hunt SR, Mutch MG, Fleshman JW and Lin AY: Clinically enlarged lateral pelvic lymph nodes do not influence prognosis after neoadjuvant therapy and TME in stage III rectal cancer. J Gastrointest Surg 15: 1368-1374, 2011.
46. Otowa Y, Yamashita K, Kanemitsu K, Sumi Y, Yamamoto M, Kanaji S, Imanishi T, Nakamura T, Suzuki S, Tanaka K, Kakeji Y. Treating patients with advanced rectal cancer and lateral pelvic lymph nodes with preoperative chemoradiotherapy based on pretreatment imaging. Onco Targets Ther. 2015 ; 8:3169-73.
47. Kim MJ, Chan Park S, Kim TH, Kim DY, Kim SY, Baek JY, Chang HJ, Park JW, Oh JH. Is lateral pelvic node dissection necessary after preoperative chemoradiotherapy for rectal cancer patients with initially suspected lateral pelvic node? Surgery. 2016 ;160(2):366-76.
48. Oh HK, Kang SB, Lee SM, Lee SY, Ihn MH, Kim DW, et al. Neoadjuvant chemoradiotherapy affects the indications for lateral pelvic node dissection in mid/low rectal cancer with clinically suspected lateral node involvement: A multicenter retrospective cohort study. Ann Surg Oncol 2014;21:2280-7.
49. Kim TH, Jeong SY, Choi DH, et al. Lateral lymph node metastasis is a major cause of locoregional recurrence in rectal cancer treated with preoperative chemoradiotherapy and curative resection. Ann Surg Oncol. 2008;15:729–737. 19.
50. Nagasaki T, Akiyoshi T, Fujimoto Y, Konishi T, Nagayama S, Fukunaga Y, Ueno M. Preoperative Chemoradiotherapy Might Improve the Prognosis of Patients with Locally Advanced Low Rectal Cancer and Lateral Pelvic Lymph Node Metastases. WJSurg 2017; 41 (3): 876-883.
51. Park JS, Choi GS, Lim KH, Jang YS, Kim HJ, Park SY, Jun SH. Laparoscopic extended lateral pelvic node dissection following total mesorectal excision for advanced rectal cancer: initial clinical experience. Surg Endosc 2011; 25:3322–3329.
52. Liang JT. Technical feasibility of laparoscopic lateral pelvic lymph node dissection for patients with low rectal cancer after concurrent chemoradiation therapy. Ann Surg Oncol 2011; 18:153–159
53. Furuhata T, Okita K, Nishidate T, Ito T, Yamaguchi H, Ueki T, Akizuki E, Meguro M, Ogawa T, Kukita K, Kimura Y, Mizuguchi T, Hirata K (2014) Clinical feasibility of laparoscopic lateral pelvic lymph node dissection following total mesorectal excision for advanced rectal cancer. Surg Today 45:310–314
54. Mukai T, Akiyoshi T, Ueno M, Fukunaga Y, Nagayama S, Fujimoto Y, Konishi T, Ikeda A, Yamaguchi T (2013) Laparoscopic total pelvic exenteration with en bloc lateral lymph node dissection after neoadjuvant chemoradiotherapy for advanced primary rectal cancer. Asian J Endosc Surg 6:314–317
55. Yamaguchi T, Konishi T, Kinugasa Y, Yamamoto S, Akiyoshi T, Okamura R, Ito M, Nishimura Y, Shiozawa M, Yamaguchi S, Hida K, Sakai Y, Watanabe M. Laparoscopic Versus Open Lateral Lymph Node Dissection for Locally Advanced Low Rectal Cancer: A Subgroup Analysis of a Large Multicenter Cohort Study in Japan. Dis Colon Rectum. 2017 ;60(9):954-964
56. Ueno M, Oya M, Azekura K, et al. Incidence and prognostic significance of lateral lymph node metastasis in patients with advanced low rectal cancer. Br J Surg. 2005;92:756–63.
57. Konishi T, Kuroyanagi H, Oya M, et al. Multimedia article. Lateral lymph node dissection with preoperative chemoradiation for locally advanced lower rectal cancer through a laparoscopic approach. Surg Endosc. 2011;25:2358–9.
58. Moriya Y, Sugihara K, Akasu T, et al. Nerve-sparing surgery with lateral node dissection for advanced lower rectal cancer. Eur J Cancer. 1995;31A:1229–1232.
59. Matsuoka H, Masaki T, Sugiyama M. et al. Impact of lateral pelvic lymph node dissection on evacuatory and urinary functions following low anterior resection for advanced rectal carcinoma. Langenbecks Arch Surg (2005) 390: 517–522.2005
60. Akiyoshi T, Nagata J, Nagasaki T, et al. Laparoscopic salvage lateral pelvic lymph node dissection for locally recurrent rectal cancer. Colorectal Dis. 2015;17(10):O213-216 2015
61. Kim HJ, Choi GS, Park JS, et al. Selective lateral pelvic lymph node dissection: a comparative study of the robotic versus laparoscopic approach. Surg Endosc. 2017; 32(5):2466-2473
62. Moriya Y. Treatment of lateral pelvic nodes metastases from rectal cancer: the future prospective. G Chir. 2013; 34(9-10):245-8.
63. Sammour T, Chang GJ. Lateral Node Dissection in Low Rectal Cancer: Time for a Global Approach? Ann Surg 2017; 20: 1-2.
64. Lee D, Matsuda T, Yamashita K, Hasegawa H, Yamamoto M, Kanaji S, Oshikiri T, Nakamura T et al. Significance of Lateral Pelvic Lymph Node Size in Predicting Metastasis and Prognosis in Rectal Cancer. Anticancer Res 2019; 39: 003-998.
65. Malakorn S, Yang Y, Bednarski BK, Kaur H, You YN, Holliday EB et al. Who Should Get Lateral Pelvic Lymph Node Dissection After Neoadjuvant Chemoradiation? Dis Colon Rectum 2019; 62: 1158–1166
66. Christou N, Meyer J, Toso C, Ris F, Buchs NC. Lateral lymph node dissection for low rectal cancer: Is it necessary? World J Gastroenterol 2019; 25(31): 4294-4299
67. Chan DK, Tan KK, Akiyoshi T. Diagnostic and management strategies for lateral pelvic lymph nodes in low rectal cancer—a review of the evidence. J Gastrointest Oncol 2019;10(6):1200-1206.
68. Kusters M, Uehara K, Cornelis J. H. van de Velde, Moriya Y. Is There Any Reason to Still Consider Lateral Lymph Node Dissection in Rectal Cancer? Rationale and Technique. Clin Colon Rectal Surg 2017; 30: 346–356.
2. Kodeda K, Johansson R, Zar n, et al. Time trends, improvements and national auditing of rectal cancer management over an 18-year period. Colorectal Dis. 2015;17:o168–o179.
3. Kim TG, Park W, Choi DH, Park HC, Kim SH, Cho YB, Yun SH, Kim HC, Lee WY, Lee J, Park JO, Park YS, Lim HY, Kang WK, Chun HK. Factors associated with lateral pelvic recurrence after curative resection following neoadjuvant chemoradiotherapy in rectal cancer patients. Int J Colorectal Dis. 2014 ;29(2):193-200.
4. Ueno H, Mochizuki H, Hashiguchi Y, Ishiguro M, Miyoshi M, Kajiwara Y, et al. Potential prognostic benefit of lateral pelvic node dissection for rectal cancer located below the peritoneal reflection. Ann Surg 2007;245:80-7.
5. Sato H, Maeda K, Maruta M, Masumori K, Koide Y. Who can get the beneficial effect from lateral lymph node dissection for Dukes C rectal carcinoma below the peritoneal reflection? Dis Colon Rectum 2006;49:S3-12 .
6. Villemin F, Huard P, Montagn’e M. Recherches anatomiques sur les lymphatiques du rectum et de l’anus: leur applications dans le traitement chirurgical du cancer. Rev Chir. 1925;63:39–80.
7. Sauer I, Bacon HE (1952) A new approach for excision of carcinoma of the lower portion of the rectum and anal canal. Surg Gynecol Obstet 95:229–242 .
8. Stearns MWJr, Deddish MR. Five-year results of abdominopelvic lymph node dissection for carcinoma of the rec- tum. Dis Colon Rectum 1959;2:169-172.
9. Takahashi T, Ueno M, Azekura K et al (2000) Lateral node dissection and total mesorectal excision for rectal cancer. Dis Colon Rectum 43:S59–S68 .
10. Wang Z, Loh KY, Tan KY, Woo EC (2012) The role of lateral lymph node dissection in the management of lower rectal cancer. Langenbeck's Arch Surg 397:353–361.
11. Kim JC, Takahashi K, Yu CS, et al. Comparative outcome between chemoradiotherapy and lateral pelvic lymph node dissection following total mesorectal excision in rectal cancer. Ann Surg. 2007;246(5): 754–762.
12. Kusters M, Beets GL, vandeVelde CJ et al. A comparison between the treatment of low rectal cancer in Japan and the Netherlands, focusing on the patterns of local recurrence. Ann Surg. 2009;249(2):229–235.
13. Georgiou P, Tan E, Gouvas N, Antoniou A, Brown G, Nicholls RJ, Tekkis P (2009) Extended lymphadenectomy versus conventional surgery for rectal cancer: a meta-analysis. Lancet Oncol 2009;10: 1053-1062.
14. Cheng H, Deng Z, Wang ZJ et al (2011) Lateral lymph node dissection with radical surgery versus single radical surgery for rectal cancer: a meta-analysis. Asian Pac J Cancer Prev 12:2517–2521.
15. Akiyoshi T, Watanabe T, Miyata S, Kotake K, Muto T and Sugihara K; Japanese Society for Cancer of the Colon and Rectum: Results of a Japanese nationwide multi-institutional study on lateral pelvic lymph node metastasis in low rectal cancer: Is it regional or distant disease? Ann Surg 2012; 255: 1129-1134.
16. Watanabe T, Itabashi M, Shimada Y et al. Japanese society for cancer of the colon and rectum (JSCCR) Guidelines 2014 for treatment of colorectal cancer. Int J Clin Oncol 2015; 20:207–239
17. Fujita S, Mizusawa J, Kanemitsu Y, Ito M, Kinugasa Y, Komori K, Ohue M, Ota M, Akazai Y, Shiozawa M, Yamaguchi T, Bandou H, Katsumata K, Murata K, Akagi Y, Takiguchi N, Saida Y, Nakamura K, Fukuda H, Akasu T, Moriya Y; Colorectal Cancer Study Group of Japan Clinical Oncology Group. Mesorectal Excision With or Without Lateral Lymph Node Dissection for Clinical Stage II/III Lower Rectal Cancer (JCOG0212): A Multicenter, Randomized Controlled, Noninferiority Trial. Ann Surg. 2017; 266(2):201-207.
18. Sugihara K, Kobayashi H, Kato T, et al. Indication and benefit of pelvic sidewall dissection for rectal cancer. Dis Colon Rectum. 2006; 49:1663–1672.
19. Kobayashi H, Mochizuki H, Kato T, et al. Outcomes of surgery alone for lower rectal cancer with and without pelvic sidewall dissection. Dis Colon Rectum. 2009;52:567–576.
20. Ozawa H, Kotake K, Hosaka M, Hirata A, Sigihara K. Impact of Lateral Pelvic Lymph Node Dissection on the Survival of Patients with T3 and T4 Low Rectal Cancer. World J Surg. 2016;40(6):1492-9.
21. Watanabe T, Tsurita G, Muto T, Sawada T, Sunouchi K, Higuchi Y, Komuro Y, Kanazawa T, Iijima T, Miyaki M and Nagawa H: Extended lymphadenectomy and preoperative radiotherapy for lower rectal cancers. Surgery 2002; 132: 27-33.
22. Ishihara S, Watanabe T, fukushima Y, et al. safety and factors contributing to the dificulty of laparoscopic surgery for rectal cancer treated with preoperative chemoradiotherapy. Tech Coloproctol. 2014;18:247–255.
23. Ishihara S, Kanemitsu Y, Murono K, Otani K, Koji Y, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata K, Nozawa H, Kazama S, Yamaguchi H, Sunami E, Sugihara K, Watanabe T. Oncological benefit of lateral pelvic lymph node dissection for rectal cancer treated without preoperative chemoradiotherapy: a multicenter retrospective study using propensity score analysis. Int J Colorectal Dis 2016; 31:1315–1321.
24. Ishihara S, Kawai K, tanaka T, Kiyomatsu T, Hata K, Nozawa H, Morikawa T, Watanabe T. Oncological Outcomes of Lateral Pelvic Lymph Node Metastasis in Rectal Cancer Treated With Preoperative Chemoradiotherapy . Dis Colon Rectum 2017; 60: 469–476.
25. Nagayoshi K, Ueki T, Manabe T, Moriyama T, Yanai K, Oda Y, Tanaka M. Laparoscopic lateral pelvic lymph node dissection is achievable and offers advantages as a minimally invasive surgery over the open approach. Surg Endosc 2015; 30 (5): 1938-47.
26. Watanabe T, Itabashi M, Shimada Y, Tanaka S, Ito Y, Ajioka Y, Hamaguchi T, Hyodo I, Igarashi M, Ishida H, Ishiguro M, Kanemitsu Y, Kokudo N, Muro K, Ochiai A, Oguchi M, Ohkura Y, Saito Y, Sakai Y, Ueno H, Yoshino T, Fujimori T, Koinuma N, Morita T, Nishimura G, Sakata Y, Takahashi K, Takiuchi H, Tsuruta O, Yamaguchi T, Yoshida M, Yamaguchi N, Kotake K, Sugihara K; Japanese Society for Cancer of the Colon and Rectum. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer. Int J Clin Oncol. 2012 Feb;17(1):1-29.
27. Fujita S. Incidence and prognosis of lower rectal cancer with limited extramesorectal lymph node metastasis. Int J Colorectal Dis. 2014 ; 29(9):1077-80.
28. Kim MJ, Kim TH, Kim DY, et al. Can chemoradiation allow for omission of lateral pelvic node dissection for locally advanced rectal cancer? J Surg Oncol. 2015;111:459–464.
29. Kusters M, Slater A, Muirhead R, Hompes R, Guy RJ, Jones OM, George BD, Lindsey I, Mortensen NJ, Cunningham C. What To Do With Lateral Nodal Disease in Low Locally Advanced Rectal Cancer? A Call for Further Reflection and Research. Dis Colon Rectum. 2017 ; 60(6):577-585.
30. Gleeson FC, Clain JE, Rajan E, Topazian MD, Wang KK, Levy MJ. EUS-FNA assessment of extramesenteric lymph node status in primary rectal cancer. Gastrointest Endosc. 2011;74(4):897-905
31. Shihab OC, Taylor F, Bees N, Blake H, Jeyadevan N, Bleehen R, Blomqvist L, Creagh M, George C, Guthrie A, Massouh H, Peppercorn D, Moran BJ, Heald RJ, Quirke P, Tekkis P, Brown G. MERCURY Study Group. Relevance of magnetic resonance imaging-detected pelvic sidewall lymph node involvement in rectal cancer. Br J Surg. 2011 ;98(12):1798-804.
32. Kobayashi H, Kikuchi A, Okazaki S, et al. Diagnostic performance of multidetector row computed tomography for assessment of lymph node metastasis in patients with distal rectal cancer. Ann Surg Oncol. 2015;22:203–208.
33. Ishibe A, Ota M, Watanabe J, et al. Prediction of lateral pelvic lymph-node metastasis in low rectal cancer by magnetic resonance imaging. World J Surg. 2016;40:995–1001.
34. Ogawa S, Hida JI, Ike H, Kinugasa T, Ota M, Shinto E, Itabashi M, Okamoto T, Yamamoto M, Sugihara K, Watanabe T. Prediction of lateral pelvic lymph node metastasis from lower rectal cancer using magnetic resonance imaging and risk factors for metastasis: Multicenter study of the Lymph Node Committee of the Japanese Society for Cancer of the Colon and Rectum. Int J Colorectal Dis. 2017 Oct;32(10):1479-1487.
35. Shihab OC, Taylor F, Bees N et al. Relevance of magnetic resonance imaging-detected pelvic sidewall lymph node involvement in rectal cancer. Br J Surg. 2011;98:1798–1804.
36. Nelson H, Petrelli N, Carlin A, et al. Guidelines 2000 for colon and rectal cancer surgery. J Natl Cancer Inst. 2001;93:583–596.
37. Akiyoshi T, Ueno M, Matsueda K, Konishi T, Fujimoto Y, Nagayama S, Fukunaga Y, Unno T, Kano A, Kuroyanagi H, et al: Selective lateral pelvic lymph node dissection in patients with advanced low rectal cancer treated with preoperative chemoradiotherapy based on pretreatment imaging. Ann Surg Oncol 21: 189-196, 2014.
38. Matsumoto T, Ohue M, Sekimoto M, Yamamoto H, Ikeda M, Monden M. Feasibility of autonomic nerve-preserving surgery for advanced rectal cancer based on analysis of micrometastases. Br J Surg. 2005 ;92(11):1444-8..
39. Coy CS, Meirelles LR, Leal RF et al. Evaluation of lateral lymph node metastases in advanced distal rectal cancer. Hepatogastroenterology 2010; 57:1363–1366
40. Inoue Y, Saigusa S, Hiro J, Toiyama Y, Araki T, Tanaka K, Mohri Y, Kusunoki M. Clinical significance of enlarged lateral pelvic lymph nodes before and after preoperative chemoradiotherapy for rectal cancer. Mol Clin Oncol. 2016 ;4(6):994-1002.
41. Ishihara S, Kawai K, Tanaka T, Kiyomatsu T, Hata K, Nozawa H, Morikawa T, Watanabe T. Oncological Outcomes of Lateral Pelvic Lymph Node Metastasis in Rectal Cancer Treated With Preoperative Chemoradiotherapy. Dis Colon Rectum. 2017; 60(5):469-476
42. Moriya Y, Sugihara K, Akasu T, et al. Importance of extended lymphadenectomy with lateral node dissection for advanced lower rectal cancer. World J Surg. 1997;21:728 – 732.
43. Lopez-Kostner F, Lavery IC, Hool GR, et al. Total mesorectal excision is not necessary for cancers of the upper rectum. Surgery. 1998;124:612–617.
44. Zaheer S, Pemberton JH, Farouk R, et al. Surgical treatment of adenocarcinoma of the rectum. Ann Surg. 1998;227:800–811.
45. Dharmarajan S, Shuai D, Fajardo AD, Birnbaum EH, Hunt SR, Mutch MG, Fleshman JW and Lin AY: Clinically enlarged lateral pelvic lymph nodes do not influence prognosis after neoadjuvant therapy and TME in stage III rectal cancer. J Gastrointest Surg 15: 1368-1374, 2011.
46. Otowa Y, Yamashita K, Kanemitsu K, Sumi Y, Yamamoto M, Kanaji S, Imanishi T, Nakamura T, Suzuki S, Tanaka K, Kakeji Y. Treating patients with advanced rectal cancer and lateral pelvic lymph nodes with preoperative chemoradiotherapy based on pretreatment imaging. Onco Targets Ther. 2015 ; 8:3169-73.
47. Kim MJ, Chan Park S, Kim TH, Kim DY, Kim SY, Baek JY, Chang HJ, Park JW, Oh JH. Is lateral pelvic node dissection necessary after preoperative chemoradiotherapy for rectal cancer patients with initially suspected lateral pelvic node? Surgery. 2016 ;160(2):366-76.
48. Oh HK, Kang SB, Lee SM, Lee SY, Ihn MH, Kim DW, et al. Neoadjuvant chemoradiotherapy affects the indications for lateral pelvic node dissection in mid/low rectal cancer with clinically suspected lateral node involvement: A multicenter retrospective cohort study. Ann Surg Oncol 2014;21:2280-7.
49. Kim TH, Jeong SY, Choi DH, et al. Lateral lymph node metastasis is a major cause of locoregional recurrence in rectal cancer treated with preoperative chemoradiotherapy and curative resection. Ann Surg Oncol. 2008;15:729–737. 19.
50. Nagasaki T, Akiyoshi T, Fujimoto Y, Konishi T, Nagayama S, Fukunaga Y, Ueno M. Preoperative Chemoradiotherapy Might Improve the Prognosis of Patients with Locally Advanced Low Rectal Cancer and Lateral Pelvic Lymph Node Metastases. WJSurg 2017; 41 (3): 876-883.
51. Park JS, Choi GS, Lim KH, Jang YS, Kim HJ, Park SY, Jun SH. Laparoscopic extended lateral pelvic node dissection following total mesorectal excision for advanced rectal cancer: initial clinical experience. Surg Endosc 2011; 25:3322–3329.
52. Liang JT. Technical feasibility of laparoscopic lateral pelvic lymph node dissection for patients with low rectal cancer after concurrent chemoradiation therapy. Ann Surg Oncol 2011; 18:153–159
53. Furuhata T, Okita K, Nishidate T, Ito T, Yamaguchi H, Ueki T, Akizuki E, Meguro M, Ogawa T, Kukita K, Kimura Y, Mizuguchi T, Hirata K (2014) Clinical feasibility of laparoscopic lateral pelvic lymph node dissection following total mesorectal excision for advanced rectal cancer. Surg Today 45:310–314
54. Mukai T, Akiyoshi T, Ueno M, Fukunaga Y, Nagayama S, Fujimoto Y, Konishi T, Ikeda A, Yamaguchi T (2013) Laparoscopic total pelvic exenteration with en bloc lateral lymph node dissection after neoadjuvant chemoradiotherapy for advanced primary rectal cancer. Asian J Endosc Surg 6:314–317
55. Yamaguchi T, Konishi T, Kinugasa Y, Yamamoto S, Akiyoshi T, Okamura R, Ito M, Nishimura Y, Shiozawa M, Yamaguchi S, Hida K, Sakai Y, Watanabe M. Laparoscopic Versus Open Lateral Lymph Node Dissection for Locally Advanced Low Rectal Cancer: A Subgroup Analysis of a Large Multicenter Cohort Study in Japan. Dis Colon Rectum. 2017 ;60(9):954-964
56. Ueno M, Oya M, Azekura K, et al. Incidence and prognostic significance of lateral lymph node metastasis in patients with advanced low rectal cancer. Br J Surg. 2005;92:756–63.
57. Konishi T, Kuroyanagi H, Oya M, et al. Multimedia article. Lateral lymph node dissection with preoperative chemoradiation for locally advanced lower rectal cancer through a laparoscopic approach. Surg Endosc. 2011;25:2358–9.
58. Moriya Y, Sugihara K, Akasu T, et al. Nerve-sparing surgery with lateral node dissection for advanced lower rectal cancer. Eur J Cancer. 1995;31A:1229–1232.
59. Matsuoka H, Masaki T, Sugiyama M. et al. Impact of lateral pelvic lymph node dissection on evacuatory and urinary functions following low anterior resection for advanced rectal carcinoma. Langenbecks Arch Surg (2005) 390: 517–522.2005
60. Akiyoshi T, Nagata J, Nagasaki T, et al. Laparoscopic salvage lateral pelvic lymph node dissection for locally recurrent rectal cancer. Colorectal Dis. 2015;17(10):O213-216 2015
61. Kim HJ, Choi GS, Park JS, et al. Selective lateral pelvic lymph node dissection: a comparative study of the robotic versus laparoscopic approach. Surg Endosc. 2017; 32(5):2466-2473
62. Moriya Y. Treatment of lateral pelvic nodes metastases from rectal cancer: the future prospective. G Chir. 2013; 34(9-10):245-8.
63. Sammour T, Chang GJ. Lateral Node Dissection in Low Rectal Cancer: Time for a Global Approach? Ann Surg 2017; 20: 1-2.
64. Lee D, Matsuda T, Yamashita K, Hasegawa H, Yamamoto M, Kanaji S, Oshikiri T, Nakamura T et al. Significance of Lateral Pelvic Lymph Node Size in Predicting Metastasis and Prognosis in Rectal Cancer. Anticancer Res 2019; 39: 003-998.
65. Malakorn S, Yang Y, Bednarski BK, Kaur H, You YN, Holliday EB et al. Who Should Get Lateral Pelvic Lymph Node Dissection After Neoadjuvant Chemoradiation? Dis Colon Rectum 2019; 62: 1158–1166
66. Christou N, Meyer J, Toso C, Ris F, Buchs NC. Lateral lymph node dissection for low rectal cancer: Is it necessary? World J Gastroenterol 2019; 25(31): 4294-4299
67. Chan DK, Tan KK, Akiyoshi T. Diagnostic and management strategies for lateral pelvic lymph nodes in low rectal cancer—a review of the evidence. J Gastrointest Oncol 2019;10(6):1200-1206.
68. Kusters M, Uehara K, Cornelis J. H. van de Velde, Moriya Y. Is There Any Reason to Still Consider Lateral Lymph Node Dissection in Rectal Cancer? Rationale and Technique. Clin Colon Rectal Surg 2017; 30: 346–356.