Role of the Insulin-like growth factor axis and the Transforming growth factor-β in the regulation of the placenta and the pathogenesis of Gestational Trophoblastic Diseases
Main Article Content
Adriana Umana-Perez
http://orcid.org/0000-0001-9262-2699
Susana Novoa-Herran
http://orcid.org/0000-0003-2157-1008
Juan Jose Castro
http://orcid.org/0000-0002-7107-1303
Andres Correa-Sanchez
http://orcid.org/0000-0003-1423-3449
Valentina Guevara
http://orcid.org/0000-0003-1535-615X
David Alejandro Lopez-Gonzalez
http://orcid.org/0000-0003-3091-9950
Myriam Sanchez-Gomez
http://orcid.org/0000-0001-9262-2699
Susana Novoa-Herran
http://orcid.org/0000-0003-2157-1008
Juan Jose Castro
http://orcid.org/0000-0002-7107-1303
Andres Correa-Sanchez
http://orcid.org/0000-0003-1423-3449
Valentina Guevara
http://orcid.org/0000-0003-1535-615X
David Alejandro Lopez-Gonzalez
http://orcid.org/0000-0003-3091-9950
Myriam Sanchez-Gomez
Abstract
During human pregnancy, the trophoblast develops as the fetal compartment, while in bidirectional communication with the maternal decidua. The trophoblast is responsible for the adequate implantation of the embryo, supply of nutrients and environmental protection of the fetus along the progress of pregnancy. To perform these functions trophoblast cells, undergo a complex and finely tuned differentiation into specialized groups of cells, in a process regulated by several hormones, growth factors and cytokines. Abnormalities in trophoblast function result in several pregnancy complications.
In this review, we focus our attention on two growth factors with pivotal roles during human pregnancy. The Insulin-like growth factor (IGF) family and the Transforming growth factor (TGF-β) axis are important regulators of the proliferation, differentiation, apoptosis, migration and invasion of human trophoblasts. We summarize what is described in the literature on how these factors and their receptors are expressed on the different subsets of trophoblasts, the signaling pathways that transduce their corresponding actions and functional biological effects. We describe the associations that have been found between these growth factors and the group of pathologies known as Gestational Trophoblastic Diseases (GTD).
Keywords:
Trophoblasts, Placenta, Transforming Growth Factor beta, Insulin-Like Growth Factor I, Insulin-Like Growth Factor II, GTD
Article Details
How to Cite
UMANA-PEREZ, Adriana et al.
Role of the Insulin-like growth factor axis and the Transforming growth factor-β in the regulation of the placenta and the pathogenesis of Gestational Trophoblastic Diseases.
Medical Research Archives, [S.l.], v. 8, n. 10, oct. 2020.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/2247>. Date accessed: 18 nov. 2024.
doi: https://doi.org/10.18103/mra.v8i10.2247.
Section
Review Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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