Role of the Insulin-like growth factor axis and the Transforming growth factor-β in the regulation of the placenta and the pathogenesis of Gestational Trophoblastic Diseases

Main Article Content

Adriana Umana-Perez http://orcid.org/0000-0001-9262-2699 Susana Novoa-Herran http://orcid.org/0000-0003-2157-1008 Juan Jose Castro http://orcid.org/0000-0002-7107-1303 Andres Correa-Sanchez http://orcid.org/0000-0003-1423-3449 Valentina Guevara http://orcid.org/0000-0003-1535-615X David Alejandro Lopez-Gonzalez http://orcid.org/0000-0003-3091-9950 Myriam Sanchez-Gomez

Abstract

During human pregnancy, the trophoblast develops as the fetal compartment, while in bidirectional communication with the maternal decidua. The trophoblast is responsible for the adequate implantation of the embryo, supply of nutrients and environmental protection of the fetus along the progress of pregnancy. To perform these functions trophoblast cells, undergo a complex and finely tuned differentiation into specialized groups of cells, in a process regulated by several hormones, growth factors and cytokines. Abnormalities in trophoblast function result in several pregnancy complications.


In this review, we focus our attention on two growth factors with pivotal roles during human pregnancy. The Insulin-like growth factor (IGF) family and the Transforming growth factor (TGF-β) axis are important regulators of the proliferation, differentiation, apoptosis, migration and invasion of human trophoblasts. We summarize what is described in the literature on how these factors and their receptors are expressed on the different subsets of trophoblasts, the signaling pathways that transduce their corresponding actions and functional biological effects. We describe the associations that have been found between these growth factors and the group of pathologies known as Gestational Trophoblastic Diseases (GTD).

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How to Cite
UMANA-PEREZ, Adriana et al. Role of the Insulin-like growth factor axis and the Transforming growth factor-β in the regulation of the placenta and the pathogenesis of Gestational Trophoblastic Diseases. Medical Research Archives, [S.l.], v. 8, n. 10, oct. 2020. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/2247>. Date accessed: 02 dec. 2020. doi: https://doi.org/10.18103/mra.v8i10.2247.
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Review Articles

References

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