Molecular Mechanisms of Curcumin in COVID-19 Treatment and Prevention: A Global Health Perspective
Main Article Content
Abstract
Turmeric (Curcuma Longa) has a near 4000-year history of extensive medical use in South Asia. Its main physiologically active phytochemical is curcumin (diferuloylmethane), derived from the rhizome of turmeric. Curcumin is a hydrophobic polyphenol with a diketone moiety connecting two phenoxy rings. It is widely available, and exerts systemic and pleiotropic effects via several key mechanisms. Most famously, it is known to inhibit pro-inflammatory pathways such as PI3k/akt/NF-kB activation. It is also a potent antioxidant and free radical scavenger via a sequential proton loss electron transfer mechanism in ionizing solvents due to its extended conjugating ability across the entire molecule, and its ability to induce NRF-2. It has been implicated in the treatment of diseases ranging from asthma to various cancers, and is also a broad spectrum anti-microbial. COVID-19 is a novel beta-coronavirus that was declared a pandemic by the WHO in March, 2020. It is primarily a respiratory disorder, but it can spread hematogenously and effect many other organs such as the heart, nervous system, and kidneys. There is a significant intersection between the clinical manifestations of COVID-19 and curcumin’s therapeutic effects. In addition, curcumin has been shown to inhibit initial viral infectivity. Thus, there is potential for curcumin to safely both prevent and treat COVID-19 infection across the globe.
Keywords:
COVID-19, Curcumin, Anti-viral, Anti-inflammatory, Anti-oxidant, Molecular mechanisms
Article Details
How to Cite
ROBERTS, Nathan et al.
Molecular Mechanisms of Curcumin in COVID-19 Treatment and Prevention: A Global Health Perspective.
Medical Research Archives, [S.l.], v. 8, n. 10, nov. 2020.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/2248>. Date accessed: 18 nov. 2024.
doi: https://doi.org/10.18103/mra.v8i10.2248.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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