Acetylcholinesterase Inhibitors for Alzheimer’s disease: Past, Present, and Potential Future
Main Article Content
Abstract
Alzheimer’s Diseases (AD) is a neurodegenerative disorder characterized by progressive neuronal loss leading to cognitive decline. Although there is yet to be a cure nor a way to reverse the neuronal damage, there are current treatments to amend some of the cognitive symptoms associated with AD. Acetylcholinesterase inhibitors (AChEi) are the primary agents of choice and have had profound implications throughout the past decades. AChEi such as donepezil, rivastigmine, and galantamine mediates and increases cholinergic activities in the central nervous system (CNS), and have been shown to improve and preserve cognition in AD patients. Beyond the current drugs on the market, investigational discoveries continue to explore the potential of safer and more efficacious AChEi agents for the treatment of AD. There have been quite a few challenges, given the high failure rates. Yet, these very trials and studies have been a fundamental step towards better understanding the treatments of AD and have provided some insight on the potential to surpass what is currently available.
Keywords:
Alzheimer’s Diseases, acetylcholinesterase inhibitors, approved drugs
Article Details
How to Cite
TRUONG, Brandon; QUIROZ, Jose Paredes; PRIEFER, Ronny.
Acetylcholinesterase Inhibitors for Alzheimer’s disease: Past, Present, and Potential Future.
Medical Research Archives, [S.l.], v. 8, n. 12, dec. 2020.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/2271>. Date accessed: 22 dec. 2024.
doi: https://doi.org/10.18103/mra.v8i12.2271.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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13. Francis PT, Palmer AM, Snape M, Wilcock GK. The cholinergic hypothesis of Alzheimer's disease: a review of progress. J Neurol Neurosurg Psychiatry. 1999 Feb;66(2):137-47. doi: 10.1136/jnnp.66.2.137. PMID: 10071091; PMCID: PMC1736202.
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20. Colović MB, Krstić DZ, Lazarević-Pašti TD, Bondžić AM, Vasić VM. Acetylcholinesterase inhibitors: pharmacology and toxicology. Curr Neuropharmacol. 2013;11(3):315-335. doi:10.2174/1570159X11311030006
21. Qaseem A, Snow V, Cross JT Jr, et al. Current pharmacologic treatment of dementia: a clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians. Ann Intern Med. 2008;148(5):370-378. doi:10.7326/0003-4819-148-5-200803040-00008
22. Petersen RC, Lopez O, Armstrong MJ, et al. Practice guideline update summary: Mild cognitive impairment: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology. 2018;90(3):126-135. doi:10.1212/WNL.0000000000004826
23. Agboton C, et al., Impact of nighttime donepezil administration on sleep in the older adult population: A retrospective study Mental Health Clinician 4,5 (2014) 257-259 https://doi.org/10.9740/mhc.n222761
24. Bentué-Ferrer D., Tribut O., Polard, E. et al. Clinically Significant Drug Interactions with Cholinesterase Inhibitors. CNS Drugs 17, 947–963 (2003). https://doi.org/10.2165/00023210-200317130-00002
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