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Multiple sclerosis is the commonest non-traumatic disabling disease that affects young adults. The presenting signs and symptoms include several common symptoms seen in primary care. It therefore behooves primary care practitioners to recognize the disease’s presentation, mimicking diagnoses and initial workup. Management of many of the symptoms of disease exacerbations are within the purview of the primary care provider. Co-management of the patient with multiple sclerosis with a neurologist improves patient care and provides a context for management of co-morbidities. The patient-centered medical home provides many services and resources that can be of use to a multiple sclerosis patient. Vaccinations and other preventative care are important in the care of the multiple sclerosis patient, particularly those on immunosuppression therapy for their disease.
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