Biobased Hyperbranched Poly(ester)s of Precise Structure for the Release of Therapeutics

Main Article Content

Bob A. Howell Tracy Zhang Patrick B. Smith

Abstract

Hyperbrached poly(ester)s derived from naturally-occurring biomonomers may serve as excellent platforms for the sustained-release of therapeutics. Those generated from glycerol are particularly attractive. Traditionally, the difference in reactivity of the hydroxyl groups of glycerol has precluded the formation of well-defined polymers at high monomer conversion without gelation. Using the Martin-Smith model to select appropriate monomer ratios (ratios of functional groups), polymerization may be carried out to high conversion while avoiding gelation and with the assurance of a single type of endgroup. Various agents may be attached via esterification, amide formation or other process. Sustained release of the active agent may be readily achieved by enzyme-catalyzed hydrolysis.

Article Details

How to Cite
HOWELL, Bob A.; ZHANG, Tracy; SMITH, Patrick B.. Biobased Hyperbranched Poly(ester)s of Precise Structure for the Release of Therapeutics. Medical Research Archives, [S.l.], v. 9, n. 1, jan. 2021. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/2308>. Date accessed: 05 mar. 2021. doi: https://doi.org/10.18103/mra.v9i1.2308.
Section
Research Articles

References

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