Backgrounds of Computer-Aided Assessment of Morphological Structure in Polymer Drugs-Delivery Microcapsules

Main Article Content

Juliusz L. Kulikowski,, DSc

Abstract

Microcapsules are widely used as one of the drug delivery means.  The paper presents the backgrounds of a method of microcapsules size and shape assessment by computer-aided analysis of microscope images of microcapsules’ cross-sections. The method has been elaborated and is practically used to the microcapsules quality control at the Nalecz Institute of Biocybernetics and Biomedical Engineering PAS in Warsaw. Mathematical definitions of parameters describing the size, shape and inner structure of microcapsules are described in the paper. A general scheme of a computer-aided microcapsules quality assessment procedure is presented. Remarks about the limitations of the applicability of the described microcapsules assessment method are also given. On this basis, directions of future works aimed at improvement of the described microcapsules quality assessment method are suggested.

Keywords: drugs delivery, microcapsules, computer- aided image analysis, irregular shape approximation, microcapsules quality assessment

Article Details

How to Cite
KULIKOWSKI,, Juliusz L.. Backgrounds of Computer-Aided Assessment of Morphological Structure in Polymer Drugs-Delivery Microcapsules. Medical Research Archives, [S.l.], v. 9, n. 2, feb. 2021. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/2312>. Date accessed: 25 apr. 2024. doi: https://doi.org/10.18103/mra.v9i2.2312.
Section
Research Articles

References

1. Chang TMS, Macintosh FC, Mason SG. Semipermeable aqueous microcapsules: I. Preparation and properties. Can. J. Pharmacol. 1966; 44:115-128
2. Vienken J, Diamantoglou M, Hahn C, Kamusewitz H, Paul D. Considerations on development all aspects of biocompatible dialysis membranes. Artif. Organs. 1995; 19: 398-406
3. Mulder M. Basic principles of membrane te chnology. Kluwer Acad. Publishers, 1996
4. Chwojnowski A, Wojciechowski C, Dudziński K, Łukowska E, Granicka L. New type of hollow fiber membrane for cell and microorganisms cultivation and encapsulation. Desalination, 2009; 240: 9-13

5. Lalia BS, Kochkodan V, Hashaikeh R,
Hilal N. A review on membrane fabrication: Structure, properties and performance relationships. Desalination, 2013;326:77-95
6. Przytulska M, Kulikowski JL, Lewińska D, Grzeczkowicz M, Kupikowska SB. Computer-aided image analysis for microcapsules’ quality assessment. Biocybernetics and Biomed. Eng., 2015;35(4):342-350
7. Camacho FG, Grima EM, Miron AS, Pascual VG, Chisti Y. Carboxymethyl cellulose protects algal cells against hydrodynamic stress. Enzyme Microb. Technol., 2001;29:602-610
8. Liu SX, Kim JT. Characterization of surface modification of polyethersulfone membrane. Journ. Adhes. Sci. Technol., 2011;25:193-212
9. Goh CH, Wan P, Heng S, Chan LW. Alginates as a useful natural polymer for microencapsulation and therapeutic applications.Carbohydr.Polym.,2012; 1(88): 1-12
10. Kai D, Shy Liow S, Jun Loh X. Biodegradable polymers for electrospinning; Towards biomedical applications. Mater. Sci. Eng. C , 2014;45:659-670
11. Strathmann H. Introduction to membrane science and technology. Wiley, 2011
12. Zhao J, Luo G, Wu J, Xia H. Preparation of microporous silicone rubber membrane with tunable pore size via solvent evaporation-induced phase separation, Appl. Matter Interfaces, 2013; 5:2040-2046
13. Chwojnowski A, Przytulska M, Wierzbicka D, Kulikowski JL, Wojciechowski C. Membranes’ porosity evaluation by computer-aided analysis of SEM images – a preliminary study, Biocyb. and Biomed. Eng.,2012; 32(4): 65–75

14. Przytulska M, Kulikowski JL. Multi-aspect assessment and classification of porous materials designer for tissue engineering, In: Kurzynski M, Wozniak M, Burduk R (eds.). Proc.of the 10th Int. Conf. on Computer Recognition Systems CORES 2017. Springer, 2017;AISC 578;22-32

15. Przytulska M, Kulikowski JL, Wasyleczko M., Chwojnowski A., Pietka D. The evaluation of 3D morphological structure of porous membranes based on a computer-aided analysis of their 2D images, Desalination, 2018;128:11-19

16. Kulikowski JL. Remarks on parameters characterizing the properties of porous materials used in biomedicine, Innov. in Tissue Eng.& Regen.Med., 2019;1(3):1-4

17. Wart Y., Georges G., Deumie C., Amra C., Moulin P. Membrane characterization by optical methods: Ellipsometry of the scattered field. Journal of Membrane Science, 2008;318:145-153
18 Suri JS. et al. (eds.). Handbook of Biomedical Image Analysis. Vol. II: Segmentation Models Part B, Kluwer Academic/Plenum Publishers, New York, 2005; 369-450
19. Pitas I. Digital Image Processing Algorithms and Applications, A Wiley-Interscience Publication, 2000, 323-334
20. Kulikowski JL, Przytulska M. Morphological Spectra. Lambert Academic Publishing, 2020
21. Kulikowski J. Remarks on Parameters Characterizing the Properties of Porous Materials Used in Biomedicine. Innovations in Tissue Engineering & Regenerative Medicine,2019;1(3):1-4