Oesophageal varices, portal hypertensive gastropathy and spontaneous Sub-arachnoid haemorrhage in a case of liver cirrhosis diagnosed on autopsy.
Main Article Content
Alcohol remains one of the most abused substances worldwide. Studies over the years have attributed chronic alcoholism as a major risk factor to liver cirrhosis. Patients with liver cirrhosis develop portal hypertension which put them at a higher risk of having esophageal varices and other associated complications. The authors present a case of a chronic alcoholic male individual who developed cirrhosis along with other less reported complications like sub-arachnoid hemorrhage and portal hypertensive gastropathy. The paper also profiles various changes associated with esophageal varices as observed during autopsy examination.
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2. Reynolds K, Lewis B, Nolen JD, Kinney GL, Sathya B, He J: Alcohol consumption and risk of stroke: a meta-analysis. JAMA. 2003;289(5):579-588. DOI:10.1001/jama.289.5.579
3. Sharara AI, Rockey DC. Gastroesophageal variceal hemorrhage. N Engl J Med. 2001; 345:669-681. DOI: 10.1056/NEJMra003007.
4. Pluta A, Gutkowski K, Hartleb M. Coagulopathy in liver diseases. Adv Med Sci. 2010; 55:16 –21. DOI: 10.2478/v10039-010-0018-3.
5. Huang HH, Lin HH, Shih YL, Chen PJ, Chang WK, Chu HC, et al. Spontaneous intracranial haemorrhage in cirrhotic patients. Clin Neurol Neurosurg. 2008; 110:253–258. DOI: 10.1016/j.clineuro.2007.11.010
6. .Henning G,.Hendrik V, Søren JP, Peter J.,.Mette G, Henrik ST,et al. Liver cirrhosis, other liver diseases, and risk of hospitalisation for intracerebral haemorrhage. BMC Gastroenterology. 2008, 8:16 doi:10.1186/1471-230X-8-16.
7. Williams MF (2014) Outpatient management of adult alcoholism. South African Medical Journal. 104(1): 73-74. DOI: 10.7196/samj.7644.
8. Kumar V, Abbas AK, Aster JC. Robbins Basic Pathology. USA, Elsevier Saunders, Philadelphia. 2013: 607-609.
9. Anderson JR. Muir’s Textbook of Pathology. Edward Arnold Publishers, Bedford, London, 1974:538-603.
10. Finkbeiner WE, Ursell PC, Davis CL. Autopsy Pathology: A Manual and Atlas. Churchill Livingstone, Philadelphia, USA, 2004: 231-232.
11. Misra, UK., Kalita, J, Pandey S, Mandal, SK. Predictors of gastrointestinal bleeding in acute intracerebral haemorrhage. Journal of The Neurological Sciences. 25–29. DOI: 10.1016/s0022-510x(02)00415-x.
12. Rumalla, K, Mittal, MK. Gastrointestinal Bleeding in Acute Ischemic Stroke: A Population-Based Analysis of Hospitalizations in the United States. Journal of stroke and cerebrovascular diseases: The Official Journal of National Stroke Association, 1728–1735. DOI: 10.1016/j.jstrokecerebrovasdis.2016.03.044.
13. Hsu HL, Lin YH, Huang YC, Weng HH, Lee M, Huang WY, et al. Gastrointestinal haemorrhage after acute ischemic stroke and its risk factors in Asians. European Neurology 2009;62(4):212-8. doi: 10.1159/000229018.
14. Lewis EA. Gastroduodenal ulceration and haemorrhage of neurogenic origin. The British Journal of Surgery 60, 279–283. DOI: 10.1038/s41598-017-13707-3
15. Schaller BJ, Graf R, Jacobs AH. Pathophysiological changes of the gastrointestinal tract in ischemic stroke. The American Journal of Gastroenterology. 1655–1665. DOI: 10.1111/j.1572-0241.2006.00540.x
16. Feibel JH, Hardy PM, Campbell RG, Goldstein MN, Joynt RJ. Prognostic value of the stress response following stroke. JAMA 238, 1374–1376. DOI: 10.1001/jama.1977.03280140052016.
17. Kotadiya TP, Khant V, Prajapati B. A study of coagulation profile in diseases of liver: At tertiary care center hospital. Indian Journal of Pathology and Oncology. 107-111. DOI: 10.18231/2394-6792.2019.0019