Oesophageal varices, portal hypertensive gastropathy and spontaneous Sub-arachnoid haemorrhage in a case of liver cirrhosis diagnosed on autopsy.
Main Article Content
http://orcid.org/0000-0002-7606-0646
Naveen Sharma
Pardeep Yadav
Mahender Singh
Abstract
Alcohol remains one of the most abused substances worldwide. Studies over the years have attributed chronic alcoholism as a major risk factor to liver cirrhosis. Patients with liver cirrhosis develop portal hypertension which put them at a higher risk of having esophageal varices and other associated complications. The authors present a case of a chronic alcoholic male individual who developed cirrhosis along with other less reported complications like sub-arachnoid hemorrhage and portal hypertensive gastropathy. The paper also profiles various changes associated with esophageal varices as observed during autopsy examination.
Article Details
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
References
2. Reynolds K, Lewis B, Nolen JD, Kinney GL, Sathya B, He J: Alcohol consumption and risk of stroke: a meta-analysis. JAMA. 2003;289(5):579-588. DOI:10.1001/jama.289.5.579
3. Sharara AI, Rockey DC. Gastroesophageal variceal hemorrhage. N Engl J Med. 2001; 345:669-681. DOI: 10.1056/NEJMra003007.
4. Pluta A, Gutkowski K, Hartleb M. Coagulopathy in liver diseases. Adv Med Sci. 2010; 55:16 –21. DOI: 10.2478/v10039-010-0018-3.
5. Huang HH, Lin HH, Shih YL, Chen PJ, Chang WK, Chu HC, et al. Spontaneous intracranial haemorrhage in cirrhotic patients. Clin Neurol Neurosurg. 2008; 110:253–258. DOI: 10.1016/j.clineuro.2007.11.010
6. .Henning G,.Hendrik V, Søren JP, Peter J.,.Mette G, Henrik ST,et al. Liver cirrhosis, other liver diseases, and risk of hospitalisation for intracerebral haemorrhage. BMC Gastroenterology. 2008, 8:16 doi:10.1186/1471-230X-8-16.
7. Williams MF (2014) Outpatient management of adult alcoholism. South African Medical Journal. 104(1): 73-74. DOI: 10.7196/samj.7644.
8. Kumar V, Abbas AK, Aster JC. Robbins Basic Pathology. USA, Elsevier Saunders, Philadelphia. 2013: 607-609.
9. Anderson JR. Muir’s Textbook of Pathology. Edward Arnold Publishers, Bedford, London, 1974:538-603.
10. Finkbeiner WE, Ursell PC, Davis CL. Autopsy Pathology: A Manual and Atlas. Churchill Livingstone, Philadelphia, USA, 2004: 231-232.
11. Misra, UK., Kalita, J, Pandey S, Mandal, SK. Predictors of gastrointestinal bleeding in acute intracerebral haemorrhage. Journal of The Neurological Sciences. 25–29. DOI: 10.1016/s0022-510x(02)00415-x.
12. Rumalla, K, Mittal, MK. Gastrointestinal Bleeding in Acute Ischemic Stroke: A Population-Based Analysis of Hospitalizations in the United States. Journal of stroke and cerebrovascular diseases: The Official Journal of National Stroke Association, 1728–1735. DOI: 10.1016/j.jstrokecerebrovasdis.2016.03.044.
13. Hsu HL, Lin YH, Huang YC, Weng HH, Lee M, Huang WY, et al. Gastrointestinal haemorrhage after acute ischemic stroke and its risk factors in Asians. European Neurology 2009;62(4):212-8. doi: 10.1159/000229018.
14. Lewis EA. Gastroduodenal ulceration and haemorrhage of neurogenic origin. The British Journal of Surgery 60, 279–283. DOI: 10.1038/s41598-017-13707-3
15. Schaller BJ, Graf R, Jacobs AH. Pathophysiological changes of the gastrointestinal tract in ischemic stroke. The American Journal of Gastroenterology. 1655–1665. DOI: 10.1111/j.1572-0241.2006.00540.x
16. Feibel JH, Hardy PM, Campbell RG, Goldstein MN, Joynt RJ. Prognostic value of the stress response following stroke. JAMA 238, 1374–1376. DOI: 10.1001/jama.1977.03280140052016.
17. Kotadiya TP, Khant V, Prajapati B. A study of coagulation profile in diseases of liver: At tertiary care center hospital. Indian Journal of Pathology and Oncology. 107-111. DOI: 10.18231/2394-6792.2019.0019