Exposure to Antibodies Anti-Chlamydophila Pneumoniae Associated to Respiratory Symptoms of Asthma among Adolescents.

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Guadalupe García Elorriaga Maximino Miranda-García Guillermo Del Rey-Pineda Luisa María Sánchez-Zamorano Eduardo César Lazcano-Ponce Eduardo Salazar-Martínez

Abstract

Previous report shows relationship between C. pneumonie and Asthma. In this study, we assessed the association between exposure to C. pneumoniae infection and the risk of bronchial asthma in adolescents in the State of Morelos, Mexico. An analysis was performed on a population-based cohort study of 80 adolescents with respiratory symptoms of asthma defined by ISAAC and 202 healthy adolescents between 12 and 17 years old. The information was collected twice from questionnaires, anthropometry, and sampling. Excessive weight gain was determined by calculating body mass index, and exposure to the specific antibodies IgM, IgG, and IgA was detected by microimmunofluorescence. The geometric means were calculated for titers of C. pneumoniae. The odds ratio was used across multiple models. The results showed that the exposure to C. pneumoniae was very high in the study population (67.2%). All immunoglobulins were significantly increased in patients with asthma symptoms compared with the healthy population (17% for IgG, 34% for IgM, and 52% for IgA). In multiple models, the IgM and IgA immunoglobulins were found to be associated with asthma (OR, 2.4; 95% CI, 1.4–4.2 and OR, 2.4; 95% CI, 1.2–4.8, respectively). Our study reflects a high seroprevalence of C. pneumoniae in the population; this seroprevalence is higher in young people with asthma. Specific immunoglobulins to C. pneumoniae are associated with IgM and IgA. The epidemiological significance of our results influences the timely monitoring and management of infections acquired at an early age that persist, or recur, for much of the juvenile life. Additional studies are needed to validate our findings.

Article Details

How to Cite
ELORRIAGA, Guadalupe García et al. Exposure to Antibodies Anti-Chlamydophila Pneumoniae Associated to Respiratory Symptoms of Asthma among Adolescents.. Medical Research Archives, [S.l.], v. 9, n. 4, apr. 2021. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/2384>. Date accessed: 14 may 2021. doi: https://doi.org/10.18103/mra.v9i4.2384.
Section
Research Articles

References

1. Dimitrakaki V, Porpodis K, Bebetsos E, Zarogoulidis P, Papaiwannou A, Tsiouda T et al. Attitudes of asthmatic and nonasthmatic children to physical exercise. Patient Prefer Adherence. 2013; 7:81-8. doi: 10.2147/PPA.S4057

2. Laforest L, Yin D, Kocevar VS, Pacheco Y, Dickson N, Gormand F et al. Association between asthma control in children and loss of workdays by caregivers. Allergy Asthma Immunol. 2004; 93:265-71. doi: 10.1016/s1081-1206(10)61499-8

3. Gomes de Luna M de F, Gomes de Luna JR, Fisher GB, de Almeida PC, Chiesa D, Gurgel M et al. Factors associated with asthma in adolescents in the city of Fortaleza, Brazil. J Asthma. 2015; 52:485-91. doi: 10.3109/02770903.2014.984841

4. Barreto ML, Ribeiro-Silva Rde C, Malta DC, Oliveira-Campos M, Andreazzi MA, Cruz AA. Prevalence of asthma symptoms among adolescents in Brazil: National Adolescent School-based Health Survey (PeNSE 2012). Rev Bras Epidemiol. 2014; 17 Suppl 1:106-15. doi:
10.1590/1809-4503201400050009

5. Del-Rio-Navarro B, Del Rio-Chivardi JM, Berber A, Sienra-Monge JJ, Rosas-Vargas MA, Baeza-Bacab M. Asthma prevalence in children living in north Mexico City and a comparison with other Latin American cities and world regions. Allergy Asthma Proc. 2006; 27:334-40. doi: 10.2500/aap.2006.27.2880

6. Vargas Becerra MH. [Epidemiology of asthma]. Rev Alerg Mex. 2009; 56 Suppl 1:S3-9.

7. Torres Ferman IA, Vazquez Nava F, Calafell Ceballos RA, Vázquez Rodríguez EM, Almeida Arvizu VM, Barrientos Gómez MC, et al. [Asthma prevalence in adolescents. Relation to sex and active smoking]. Rev Alerg Mex. 2010; 57:146-152.

8. Fundora-Hernández H, Venero-Fernández SJ, Suárez-Medina R, Mora-Faife EL, García-García G, del Valle-Infante I et al. What are the main environmental exposures associated with elevated IgE in Cuban infants? A population-based study. Trop Med Int Health. 2014; 19:545-554. doi: 10.1111/tmi.12293

9. Guilbert TW, Denlinger LC. Role of infection in the development and exacerbation of asthma. Expert Rev Respir Med. 2010; 4:71-83. doi: 10.1586/ers.09.60

10. Patel KK, Anderson E, Salva PS, Webley WC. The prevalence and identity of Chlamydia-specific IgE in children with asthma and other chronic respiratory symptoms. Respir Res. 2012; 13:32. doi: 10.1186/1465-9921-13-32

11. Allegra L, Blasi F, Centanni S, Cosentini R, Denti F, Raccanelli R et al. Acute exacerbations of asthma in adults: role of Chlamydia pneumoniae infection. Eur Respir J. 1994; 7:2165-2168. doi: 10.1183/09031936.94.07122165

12. Hahn DL, Dodge RW, Golubjatnikov R. Association of Chlamydia pneumoniae (strain TWAR) infection with wheezing, asthmatic bronchitis, and adult-onset asthma. JAMA. 1991; 266:225-230.

13. Webley WC, Salva PS, Andrzejewski C, Cirino F, West CA, Tilahun et al. The bronchial lavage of pediatric patients with asthma contains infectious Chlamydia. Am J Respir Crit Care Med. 2005; 171:1083-88. doi: 10.1164/rccm.200407-917OC

14. Webley WC , Hahn DL. Infection-mediated asthma: etiology, mechanisms and treatment options, with focus on Chlamydia pneumoniae and macrolides. Respir Res. 2017; 18:98.doi: 10.1186/s12931-017-0584-z.

15. Cho Y, Kim T, Lee T, Moon K, Lee J, Kim Y et al. Chlamydia pneumoniae infection enhances cellular proliferation and reduces steroid responsiveness of human peripheral blood mononuclear cells via a tumor necrosis factor-alpha-dependent pathway. Clin Exp Allergy. 2005; 35:16251631. doi:10.1111/j.1365-2222.2005.02391.x

16. Hahn DL, Schure A, Patel K, Childs T, Drizik E, Webley W. Chlamydia pneumoniae-specific IgE is prevalent in asthma and is associated with disease severity. PLoS One. 2012; 7:e35945. doi:10.31371/journal.pone.0035945

17. Hahn DL, Grasmick M, Hetzel S, Yale S. Azithromycin for bronchial asthma in adults: an effectiveness trial. J Am Board Fam Med. 2012; 25:442–59. doi: 10.3122/jabfm.2012.04.110309

18. von Hertzen LC. Role of persistent infection in the control and severity of asthma: focus on Chlamydia pneumoniae. Eur Respir J. 2002; 19:546–556. doi: 10.1183/09031936.02.00254402

19. von Hertzen L, Vasankari T, Liippo K, Wahlström E, Puolakkainen M. Chlamydiapneumoniae and severity of asthma. Scand J Infect Dis. 2002; 34:22–7. doi: 10.1080/00365540110077155

20. Cook PJ, Davies P, Tunnicliffe W, Ayres JG, Honeybourne D, Wise R. Chlamydia pneumoniae and asthma. Thorax.1998; 53:254-259.doi: 10.1136/thx.53.4.254

21. Miranda Candelario JF. Atypical microorganisms in children whit community adquired pneumonia: EsSalud Grau Emergency Hospital - Period 2008. Acta Méd Peruana. 2012; 29:17-22.

22. Cabrera Navarro P, Caminero Luna J. [Risk factors in asthma]. Arch Bronconeumol. 2001; 37:248-256. doi: 10.1016/s0300-2896(01)75062-4

23. Del-Rio-Navarro BE, Castro-Rodriguez JA, Garibay Nieto N, Berber A, Toussaint G, Sienra-Monge JJ et al. Higher metabolic syndrome in obese asthmatic compared to obese nonasthmatic adolescent males. J Asthma. 2010; 47:501-506. doi: 10.3109/02770901003702808

24. Barquera S, Campos-Nonato I, Hernandez-Barrera L, Pedroza A, Rivera-Dommarco JA. [Prevalence of obesity in Mexican adults 2000-2012]. Salud Publica Mex. 2013; 55 Suppl 2:S151-160.

25. Lazcano-Ponce EC, Hernandez B, Cruz-Valdez A, Allen B, Díaz R, Hernández C et al. Chronic disease risk factors among healthy adolescents attending public schools in the state of Morelos, Mexico. Arch Med Res. 2003; 34:222-236. doi: 10.1016/S0188-4409(03)00042-0

26. Asher MI, Keil U, Anderson HR, Beasley R, Crane J, Martinez F et al. International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods. Eur Respir J. 1995;8:483-491. doi: 10.1183/09031936.95.08030483

27. Wang SP, Kuo CC, Grayston JT. Formalinized Chlamydia trachomatis organisms as antigen in the micro-immunofluorescence test. J Clin Microbiol. 1979;10:259-261. doi: 10.1128/JCM.10.2.259-261.1979

28. Chaim W, Sarov B, Sarov I, Piura B, Cohen A, Insler V. Serum IgG and IgA antibodies to Chlamydia in ectopic pregnancies. Contraception. 1989;40:59-71. doi: 10.1016/0010-7824(89)90028-0

29. Ben-Yaakov M, Eshel G, Zaksonski L, Lazarovich Z, Boldur I. Prevalence of antibodies to Chlamydia pneumoniae in an Israeli population without clinical evidence of respiratory infection. J Clin Pathol. 2002;55:355-358. doi: 10.1136/jcp.55.5.355

30. Al-Younes HM. High prevalence of Chlamydia pneumoniae infection in an asymptomatic Jordanian population. J Microbiol Immunol Infect. 2014;47:412-417. doi: 10.1016/j.jmii.2013.04.004

31. Nemati M, Mirzaee V, Shaabani Z, Zarrin M, Mirabdolahi SA, Bagheri-Jamebozorgi M, et al. Specific serum immunoglobulin G against Chlamydia pneumoniae in helthy children and adults in south-east of IRAN. J Ayub Med Coll Abbottabad. 2015; 27:264-267.

32. Koh WP, Taylor MB, Hughes K, Chew SK, Fong CW, Phoon MC et al. Seroprevalence of IgG antibodies against Chlamydia pneumoniae in Chinese, Malays and Asian Indians in Singapore. Int J Epidemiol. 2002;31:1001-1007. doi: 10.1093/ije/31.5.1001

33. Mills GD, Lindeman JA, Fawcett JP, Herbison GP, Sears MR. Chlamydia pneumoniae serological status is not associated with asthma in children or young adults. Int J Epidemiol. 2000;29:280-284. doi: 10.1093/ije/29.2.280

34. Ferrari M, Poli A, Olivieri M, Verlato G, Tardivo S, Nicolis M et al. Respiratory symptoms, asthma, atopy and Chlamydia pneumoniae IgG antibodies in a general population sample of young adults. Infection. 2002;30:203-207. doi: 10.1007/s15010-002-2143-9

35. Nagy A, Keszei M, Kis Z, Kis Z, Budai I, Tölgyesi G et al. Chlamydophila pneumoniae infection status is dependent on the subtypes of asthma and allergy. Allergy Asthma Proc. 2007;28:58-63. doi: 10.2500/aap.2007.28.2957

36. Paldanius M, Juvonen R, Leinonen M, Bloigu A, Silvennoinen-Kassinen S, Saikku P. Asthmatic persons are prone to the persistence of Chlamydia pneumoniae antibodies. Diagn Microbiol Infect Dis. 2007;59:117-122. doi: 10.1016/j.diagmicrobio.2007.04.004

37. Chen Z, Salam MT, Alderete TL, Habre R, Bastain TM, Berhane K et al. Effects of Childhood Asthma on the Development of Obesity among School-aged Children. Am J Respir Crit Care Med. 2017;195:1181-1188. doi: 10.1164/rccm.201608-1691OC

38. Papoutsakis C, Chondronikola M, Antonogeorgos G, Papadakou E, Matziou V, Drakouli M et al. Associations between central obesity and asthma in children and adolescents: a case-control study. J Asthma. 2015;52:128-134. doi: 10.3109/02770903.2014.954291

39. Lang JE, Bunnell HT, Hossain MJ, Wysocki, T, Lima JJ, Finkel TH et al. Being overweight or obese and the development of asthma. Pediatrics. 2018;142:e20182119.doi: 10.1542/peds.2018-2119

40. Jiang D, Wang L, Bai C, Chen O. Association between abdominal obesity and asthma: a meta‑analysis. Allergy Asthma Clin Immunol. 2019; 15:16.doi: 10.1186/s13223-019-0333-6

41. Shan L-S, Zhou Q-L, Shang Y-X. Bidirectional Association Between Asthma and Obesity During Childhood and Adolescence: A Systematic Review and Meta-Analysis. Front. Pediatr. 2020; 8:576858.doi: 10.3389/fped.2020.576858

42. Porter M, Wegienka G, Havstad S, Nageotte CG, Johnson CC, Ownby DR et al. Relationship between childhood body mass index and young adult asthma. Ann Allergy Asthma Immunol. 2012; 109:408-411.e1. doi:10.1016/j.anai.2012.09.009

43. Visness CM, London SJ, Daniels JL, Kaufman JS, Yeatts KB, Siega-Riz AM et al. Association of childhood obesity with atopic and nonatopic asthma: results from the National Health and Nutrition Examination Survey 1999-2006. J Asthma. 2010;47:822-829. doi: 10.3109/02770903.2010.489388

44. Dowell SF, Peeling RW, Boman J, Carlone GM, Fields BS, Guarner J et al. Standardizing Chlamydia pneumoniae assays: recommendations from the Centers for Disease Control and Prevention (USA) and the Laboratory Centre for Disease Control (Canada). Clin Infect Dis. 2001; 33:492-503. doi: 10.1086/322632

45. Smith-Norowitz TA, Chotikanatis K, Erstein DP, Perlman J, Norowitz YM, Joks R et al. Chlamydia pneumoniae enhances the Th2 profile of stimulated peripheral blood mononuclear cells from asthmatic patients. Hum Immunol. 2016; 77:382-388. doi: 10.1016/j.humimm.2016.02.010

46. Smith-Norowitz TA, Huang Y, Loeffler J, Klein E, Norowitz YM, Hammerschlag MR et al. Azithromycin decreases Chlamydia pneumoniae-mediated Interleukin-4 responses but not Immunoglobulin E responses. PLoS ONE. 2020; 8:15:e0234413.doi: 10.1371/journal.pone.0234413

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