Myofibroblastic sarcoma of the bone: two cases

Main Article Content

Esperanza holgado moreno Eduardo José Ortiz-Cruz José Juan Pozo-Kreilinger Manuel Peleteiro-Pensado

Abstract

Low-grade myofibroblastic sarcoma (L-G MFS) is a rare tumour that commonly affects the soft tissues of the head and neck. Its location in bone is very rare and there are few cases published in the literature, which sometimes leads to a wrong initial diagnosis.  The following report will give an overview of the clinical, radiological and histological findings in two patients with a very unusual bone sarcoma, which are more often found in the soft tissues. Treatment options and outcome will be discussed.


 


On excision of any sarcoma tumor, surgeons should be aware of the potential risk for erroneous management of malignancy. If not, careless surgery may render the treatment protocol complicated and additional bed tumor resection with poor function and prognosis.


 


Low-grade myofibroblastic sarcoma (L-G MFS) requires a wide resection to avoid local recurrence and distant metastases.


 


We present two cases with an initial diagnosis of giant cell tumor and fibrous dysplasia respectively, which were diagnosed as low-grade bone myofibroblastic sarcoma after clinical, radiological y pathological studies.

Article Details

How to Cite
HOLGADO MORENO, Esperanza et al. Myofibroblastic sarcoma of the bone: two cases. Medical Research Archives, [S.l.], v. 9, n. 5, may 2021. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/2392>. Date accessed: 25 june 2021. doi: https://doi.org/10.18103/mra.v9i5.2392.
Section
Case Reports

References

1. Mentzel T, Dry S, Katenkamp D, Fletcher CD. Low-grade myofibroblastic sarcoma: analysis of 18 cases in the spectrum of myofibroblastic tumors. Am J Surg Pathol. 1998 Oct;22(10):1228-38. DOI: 10.1097/00000478-199810000-00008.

2. Eyden B, Banerjee SS, Shenjere P, Fisher C. The myofibroblast and its tumours. J Clin Pathol. 2009 Mar;62(3):236-49. DOI: 10.1136/jcp.2008.061630. Epub 2008 Oct 17.

3. Montgomery E, Goldblum JR, Fisher C. Myofibrosarcoma: a clinicopathologic study. Am J Surg Pathol. 2001 Feb;25(2):219-28. DOI: 10.1097/00000478-200102000-00010.

4. Meng GZ, Zhang HY, Bu H, Zhang XL, Pang ZG, Ke Q, Liu X, Yang G. Myofibroblastic sarcomas: a clinicopathological study of 20 cases. Chin Med J (Engl). 2007 Mar 5;120(5):363-9.

5. Huang G, Ye F, Fu M, Chen Y. [Clinical analysis of low grade myofibroblastic sarcoma in head and neck]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2014 Aug;28(15):1148-50.

6. Watanabe K, Ogura G, Tajino T, Hoshi N, Suzuki T. Myofibrosarcoma of the bone: a clinicopathologic study. Am J Surg Pathol. 2001 Dec;25(12):1501-7. DOI: 10.1097/00000478-200112000-00005.

7. Bisceglia M, Tricarico N, Minenna P, Magro G, Pasquinelli G. Myofibrosarcoma of the upper jawbones: a clinicopathologic and ultrastructural study of two cases. Ultrastruct Pathol. 2001 Sep-Oct;25(5):385-97. DOI: 10.1080/019131201317101261.

8. San Miguel P, Fernández G, Ortiz-Rey JA, Larrauri P. Low-grade myofibroblastic sarcoma of the distal phalanx. J Hand Surg Am. 2004 Nov;29(6):1160-3. DOI: 10.1016/j.jhsa.2004.05.003.

9. Niedzielska I, Janic T, Mrowiec B. Low-grade myofibroblastic sarcoma of the mandible: a case report. J Med Case Rep. 2009 Aug 10;3:8458. DOI: 10.4076/1752-1947-3-8458.

10. Arora R, Gupta R, Sharma A, Dinda AK. A rare case of low-grade myofibroblastic sarcoma of the femur in a 38-year-old woman: a case report. J Med Case Rep. 2010 Apr 28;4:121. DOI: 10.1186/1752-1947-4-121.

11. Saito T, Mitomi H, Kurisaki A, Torigoe T, Takagi T, Suehara Y, Okubo T, Kaneko K, Yao T. Low-grade myofibroblastic sarcoma of the distal femur. Int J Surg Case Rep. 2013;4(2):195-9. DOI: 10.1016/j.ijscr.2012.11.017. Epub 2012 Nov 23.

12. Wang L, Li LX, Chen DQ, Yang L, Li SK, Cheng C. Low-grade Myofibroblastic sarcoma: clinical and imaging findings. BMC Med Imaging. 2019 May 2;19(1):36. DOI: 10.1186/s12880-018-0287-z.

13. Hadjigeorgiou GF, Samaras V, Varsos V. Low-grade myofibroblastic sarcoma of the thoracic spine: report of an extreme rare case. Br J Neurosurg.2017Dec;31(6):731-733. DOI:10.1080/02688697.2016.1220505. Epub 2016 Aug 18.

14. M Fernández-Aceñero, A Sanz-Laguna, J Carrascoso-Arran, P López-Criado. Low-Grade Myofibroblastic Sarcoma Of The Bone. The Internet Journal of Pathology. 2004 Volume 4 Number 1.

15. Mankin HJ, Lange TA, Spanier SS. The hazards of biopsy in patients with malignant primary bone and soft-tissue tumors. J Bone Joint Surg Am. 1982 Oct;64(8):1121-7.

16. Mankin HJ, Mankin CJ, Simon MA. The hazards of the biopsy, revisited. Members of the Musculoskeletal Tumor Society. J Bone Joint Surg Am. 1996 May;78(5):656-63. DOI: 10.2106/00004623-199605000-00004.

17. Agaimy A, Wünsch PH, Schroeder J, Gaumann A, Dietmaier W, Hartmann A, Hofstaedter F, Mentzel T. Low-grade abdominopelvic sarcoma with myofibroblastic features (low-grade myofibroblastic sarcoma): clinicopathological, immunohistochemical, molecular genetic and ultrastructural study of two cases with literature review. J Clin Pathol. 2008 Mar;61(3):301-6. DOI: 10.1136/jcp.2007.048561. Epub 2007 May 18.

18. Eisenstat J, Gilson T, Reimann J, Sampson B. Low-grade myofibroblastic sarcoma of the heart causing sudden death. Cardiovasc Pathol. 2008 Jan-Feb;17(1):55-9. DOI: 10.1016/j.carpath.2006.12.006. Epub 2007 Feb 22.

19. Humphries WE 3rd, Satyan KB, Relyea K, Kim ES, Adesina AM, Chintagumpala M, Jea A. Low-grade myofibroblastic sarcoma of the sacrum. J Neurosurg Pediatr. 2010 Sep;6(3):286-90. DOI: 10.3171/2010.5.PEDS09289.

20. Astrid Schenker, Burkhard Lehner, Ewgenija Gutjhar et al. Low-Grade Myofibroblastic Sarcoma (LGMS) of the Extremities – A Systematic Review and Case Report, 24 July 2020, PREPRINT (Version 1) available at Research Square [+https://doi.org/10.21203/rs.3.rs-38829/v1+]

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