The Proteomics and Fibromyalgia: A Perspective on the Study of the Inflammatory Response in Fibromyalgia
Main Article Content
Jose Luis Maldonado-García, Dr
http://orcid.org/0000-0003-2694-1290
María Teresa Vega-Ramírez, Dra
http://orcid.org/0000-0003-2450-4927
Gilberto Pérez-Sanchez, Dr
http://orcid.org/0000-0003-3878-0631
Enrique Becerril-Villanueva, Dr
http://orcid.org/0000-0001-7210-9775
Samantha Alvarez-Herrera, Dra
http://orcid.org/0000-0001-9747-885X
Danelia Mendieta-Cabrera, Dra
Martha Moreno-Lafont, Dra
http://orcid.org/0000-0003-2896-5819
Lenin Pavón, Dr
http://orcid.org/0000-0002-6067-6868
http://orcid.org/0000-0003-2694-1290
María Teresa Vega-Ramírez, Dra
http://orcid.org/0000-0003-2450-4927
Gilberto Pérez-Sanchez, Dr
http://orcid.org/0000-0003-3878-0631
Enrique Becerril-Villanueva, Dr
http://orcid.org/0000-0001-7210-9775
Samantha Alvarez-Herrera, Dra
http://orcid.org/0000-0001-9747-885X
Danelia Mendieta-Cabrera, Dra
Martha Moreno-Lafont, Dra
http://orcid.org/0000-0003-2896-5819
Lenin Pavón, Dr
http://orcid.org/0000-0002-6067-6868
Abstract
Fibromyalgia (FM) is a chronic, non-degenerative disease characterized by widespread and sustained pain, sleep disturbances, physical exhaustion, and cognitive difficulties. The FM pathophysiology has not been completely clarified, and several theories have been postulated, among which is the dysregulation of the inflammatory response as a mediator of the painful phenomenon. In addition, it has been reported that FM patients present a rise of IL-6 and IL-8 serum levels; this fact has clinical relevance since these inflammatory molecules induce symptoms such as pain, fatigue, hyperalgesia, and allodynia.
Additionally, some studies have been carried out on the participation of leukocytes in the physiopathology of fibromyalgia; The evidence suggests that mast cells are the most relevant leukocytes in the pathophysiology of FM since they promote the release of pro-inflammatory cytokines in response to stimuli such as substance P or corticotropin-releasing hormone, which were elevated in patients.
The number of FM patients is increasing year after year around the world. For this reason, it is essential to study the proteins involved in the inflammatory response in fibromyalgia. Proteomic analysis techniques such as tandem mass tag (TMT) with isobaric labeling offer a hope to find biological markers that allow the study simultaneously the participation of multiple inflammatory proteins in FM patients, allowing the identification of biomarkers. Thus, the use of isobaric tagging will allow shortly to expand the knowledge of pathophysiology in fibromyalgia, helping to identify biomarkers to improve the diagnosis of the FM disease and increase the quality of life of patients and their families.
Keywords:
Fibromyalgia, leucocytes, cytokines, proteomics, tandem mass tag, isobaric label
Article Details
How to Cite
MALDONADO-GARCÍA, Jose Luis et al.
The Proteomics and Fibromyalgia: A Perspective on the Study of the Inflammatory Response in Fibromyalgia.
Medical Research Archives, [S.l.], v. 9, n. 8, aug. 2021.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/2518>. Date accessed: 26 dec. 2024.
doi: https://doi.org/10.18103/mra.v9i8.2518.
Section
Review Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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2. Jiménez MM, Javier F, Bosquet S. Neurastenia y fibromialgia: el enlace entre el sistema nervioso y la cultura en entidades clínicas complejas. En-claves del Pensam. 2017;11(22):51-74.
3. Häuser W, Sarzi-Puttini P, Fitzcharles M-A. Fibromyalgia syndrome: under-, over- and misdiagnosis. Clin Exp Rheumatol. 2019;37 Suppl 1(1):90-97. http://www.ncbi.nlm.nih.gov/pubmed/30747096.
4. Perrot S. If fibromyalgia did not exist, we should have invented it. A short history of a controversial syndrome. Reumatismo. 2012;64(4):186-193. doi:10.4081/reumatismo.2012.186
5. Häuser W, Ablin J, Fitzcharles MA, et al. Fibromyalgia. Nat Rev Dis Prim. 2015;1(August):1-16. doi:10.1038/nrdp.2015.22
6. Sarzi-Puttini P, Giorgi V, Marotto D, Atzeni F. Fibromyalgia: an update on clinical characteristics, aetiopathogenesis and treatment. Nat Rev Rheumatol. 2020;16(11):645-660. doi:10.1038/s41584-020-00506-w
7. Hackshaw K V. The Search for Biomarkers in Fibromyalgia. Diagnostics. 2021;11(2):156. doi:10.3390/diagnostics11020156
8. Peláez-Ballestas I, Sanin LH, Moreno-Montoya J, et al. Epidemiology of the rheumatic diseases in Mexico. A study of 5 regions based on the COPCORD methodology. J Rheumatol Suppl. 2011;86(SUPPL. 86):3-8. doi:10.3899/jrheum.100951
9. Choy E, Perrot S, Leon T, et al. A patient survey of the impact of fibromyalgia and the journey to diagnosis. BMC Health Serv Res. 2010;10:102. doi:10.1186/1472-6963-10-102
10. Gendelman O, Amital H, Bar-On Y, et al. Time to diagnosis of fibromyalgia and factors associated with delayed diagnosis in primary care. Best Pract Res Clin Rheumatol. 2018;32(4):489-499. doi:10.1016/j.berh.2019.01.019
11. Lacasse A, Bourgault P, Choinière M. Fibromyalgia-related costs and loss of productivity: A substantial societal burden. BMC Musculoskelet Disord. 2016;17(1). doi:10.1186/s12891-016-1027-6
12. Berger A, Dukes E, Martin S, Edelsberg J, Oster G. Characteristics and healthcare costs of patients with fibromyalgia syndrome. Int J Clin Pract. 2007;61(9):1498-1508. doi:10.1111/j.1742-1241.2007.01480.x
13. Guymer EK, Littlejohn GO, Brand CK, Kwiatek RA. Fibromyalgia onset has a high impact on work ability in Australians. Intern Med J. 2016;46(9):1069-1074. doi:10.1111/imj.13135
14. Núñez-nevárez K, López-betancourt A, Cisneros-pérez V. Labor Condition and Severity of Fibromyalgia Condición Laboral y Severidad de la Fibromialgia. Rev Red Inv Sal Trab. 2021;4(6):54-59.
15. González E, Elorza J, Failde I. Fibromyalgia and psychiatric comorbidity: their effect on the quality of life patients. Actas Esp Psiquiatr. 38(5):295-300. http://www.ncbi.nlm.nih.gov/pubmed/21117004. Accessed June 1, 2021.
16. Coskun Benlidayi I. Role of inflammation in the pathogenesis and treatment of fibromyalgia. Rheumatol Int. 2019;39(5):781-791. doi:10.1007/s00296-019-04251-6
17. Banfi G, Diani M, Pigatto PD, Reali E. T Cell Subpopulations in the Physiopathology of Fibromyalgia: Evidence and Perspectives. Int J Mol Sci. 2020;21(4):1186. doi:10.3390/ijms21041186
18. Van West D, Maes M. Neuroendocrine and immune aspects of fibromyalgia. BioDrugs. 2001;15(8):521-531. doi:10.2165/00063030-200115080-00004
19. Bote ME, Garca JJ, Hinchado MD, Ortega E. Inflammatory/stress feedback dysregulation in women with fibromyalgia. Neuroimmunomodulation. 2012;19(6):343-351. doi:10.1159/000341664
20. Kadetoff D, Lampa J, Westman M, Andersson M, Kosek E. Evidence of central inflammation in fibromyalgia - Increased cerebrospinal fluid interleukin-8 levels. J Neuroimmunol. 2012;242(1-2):33-38. doi:10.1016/j.jneuroim.2011.10.013
21. Peck MM, Maram R, Mohamed A, et al. The Influence of Pro-inflammatory Cytokines and Genetic Variants in the Development of Fibromyalgia: A Traditional Review. Cureus. September 2020. doi:10.7759/cureus.10276
22. Totsch SK, Sorge RE. Immune system involvement in specific pain conditions. Mol Pain. 2017;13. doi:10.1177/1744806917724559
23. Theoharides TC, Tsilioni I, Bawazeer M. Mast Cells, Neuroinflammation and Pain in Fibromyalgia Syndrome. Front Cell Neurosci. 2019;13. doi:10.3389/fncel.2019.00353
24. Fries E, Hesse J, Hellhammer J, Hellhammer DH. A new view on hypocortisolism. Psychoneuroendocrinology. 2005;30(10):1010-1016. doi:10.1016/j.psyneuen.2005.04.006
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