Guillain-Barré Syndrome in a 28-Year-Old Female with Antecedent COVID 19 Infection: A Case Report

Main Article Content

Priscilla Hirst, MD Benjamin Tate Fedeles, MD Joseph J. Schlesinger, MD, FCCM


Various neurological manifestations have been observed throughout the SARS-CoV-2 disease (COVID-19) pandemic. However, few cases of Guillain-Barré syndrome (GBS) in association with COVID-19 have been described. We submit a unique case of a previously healthy 28-year-old woman who presented with ascending weakness including facial diplegia, areflexia and respiratory compromise consistent with GBS Miller Fisher variant in the setting of recent COVID-19 infection one month prior to symptom onset. 

Article Details

How to Cite
HIRST, Priscilla; FEDELES, Benjamin Tate; SCHLESINGER, Joseph J.. Guillain-Barré Syndrome in a 28-Year-Old Female with Antecedent COVID 19 Infection: A Case Report. Medical Research Archives, [S.l.], v. 9, n. 9, sep. 2021. ISSN 2375-1924. Available at: <>. Date accessed: 17 apr. 2024. doi:
Case Reports


1. Mao L, Jin H, Wang M, et al. Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. JAMA Neurol. 2020;77(6):683-690. doi:10.1001/jamaneurol.2020.1127

2. Zhou Z, Kang H, Li S, Zhao X. Understanding the neurotropic characteristics of SARS-CoV-2: from neurological manifestations of COVID-19 to potential neurotropic mechanisms. J Neurol. 2020;267(8):2179-2184. doi:10.1007/s00415-020-09929-7

3. Hughes RA, Cornblath DR. Guillain-Barré syndrome. Lancet. 2005;366(9497):1653-1666. doi:10.1016/S0140-6736(05)67665-9

4. Piccione EA, Salame K, Katirji B (2014) Guillain-Barré syndrome and related disorders. In: Katirji B, Kaminski HJ, Ruff RL (eds) Neuromuscular disorders in clinical practice. Springer New York, New York, NY, pp 573–603

5. Rahimi K. Guillain-Barre syndrome during COVID-19 pandemic: an overview of the reports [published correction appears in Neurol Sci. 2020 Sep 23;:]. Neurol Sci. 2020;41(11):3149-3156. doi:10.1007/s10072-020-04693-y

6. Helms J, Kremer S, Merdji H, et al. Neurologic Features in Severe SARS-CoV-2 Infection. N Engl J Med. 2020;382(23):2268-2270. doi:10.1056/NEJMc2008597

7. Moriguchi T, Harii N, Goto J, et al. A first case of meningitis/encephalitis associated with SARS-Coronavirus-2. Int J Infect Dis. 2020;94:55-58. doi:10.1016/j.ijid.2020.03.062

8. Gupta A, Paliwal VK, Garg RK. Is COVID-19-related Guillain-Barré syndrome different?. Brain Behav Immun. 2020;87:177-178. doi:10.1016/j.bbi.2020.05.051

9. Fisher M. An unusual variant of acute idiopathic polyneuritis (syndrome of ophthalmoplegia, ataxia and areflexia). N Engl J Med. 1956;255(2):57-65. doi:10.1056/NEJM195607122550201

10. Willison HJ, Veitch J, Paterson G, Kennedy PG. Miller Fisher syndrome is associated with serum antibodies to GQ1b ganglioside. J Neurol Neurosurg Psychiatry. 1993;56(2):204-206. doi:10.1136/jnnp.56.2.204

11. Yuki N, Hartung HP. Guillain-Barré syndrome [published correction appears in N Engl J Med. 2012 Oct 25;367(17):1673]. N Engl J Med. 2012;366(24):2294-2304. doi:10.1056/NEJMra1114525

12. Zhao H, Shen D, Zhou H, Liu J, Chen S. Guillain-Barré syndrome associated with SARS-CoV-2 infection: causality or coincidence?. Lancet Neurol. 2020;19(5):383-384. doi:10.1016/S1474-4422(20)30109-5

13. Gutiérrez-Ortiz C, Méndez-Guerrero A, Rodrigo-Rey S, et al. Miller Fisher syndrome and polyneuritis cranialis in COVID-19. Neurology. 2020;95(5):e601-e605. doi:10.1212/WNL.0000000000009619

14. Dinkin M, Gao V, Kahan J, et al. COVID-19 presenting with ophthalmoparesis from cranial nerve palsy. Neurology. 2020;95(5):221-223. doi:10.1212/WNL.0000000000009700

15. Kamel WA. et al. Guillain-Barré syndrome following COVID-19 Infection: First Case Report from Kuwait and Review of the Literature. Dubai Med J. 2021;4:107-111.

16. Giannis D, Ziogas IA, Gianni P. Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past. J Clin Virol. 2020;127:104362. doi:10.1016/j.jcv.2020.104362