COVID 19 Severity Correlation between Inflammatory Markers and High Resolution Computerised Tomography

Coronavirus disease (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. The outbreak of SARS-CoV-2 was considered to have originally started via a zoonotic transmission associated with the seafood market in Wuhan, China. Later it was recognized that human to human transmission played a major role in the subsequent outbreak. The Inflammatory responses caused by  viral replication of SARS-CoV-2 with cellular destruction can recruit macrophages and monocytes and lead to the release of cytokines and chemokines.These  inflammatory markers then attract immune cells and activate immune responses, leading to cytokine storms .Many such inflammatory markers have been attributed to determine the severity of SARS-CoV-2 disease   and mortality associated with it. The Inflammatory markers such as   serum ferritin, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and interleukin-6 (IL-6) have been reported to be significantly associated with the high risks of the development of severe COVID-19 disease.  

Aims and objectives

The aim of the study was to find out correlation between inflammatory markers and HRCT chest severity in hospitalised COVID-19 patients.

 Results and conclusion.

 The study supported the existing data that high load of inflammatory markers is associated with more severe COVID-19 lung disease and indirectly high mortality ,out of four inflammatory markers which included D Dimer ,IL6,Serum ferritin and LDH we found three markers  IL6,Serum ferritin and LDH has significant relation with CT severity