A Case of Myopericarditis and the HPV vaccine

Main Article Content

Angela H Pegram, PharmD, BCPS, CDCES Tara V Bush, PA-C



Human Papillomavirus (HPV) is the underlying etiology of numerous cancers and genital warts in both males and females.  Vaccines were developed against HPV to prevent transmission and arrest development of cancers caused by the virus.  Gardasil 9â is the newest vaccine, covering 9 serotypes of HPV and is recommended by the CDC for both males and females over 9 years of age in a series of vaccinations. Myopericarditis (including myocarditis and pericarditis) is not reported as an adverse reaction in the Gardasil 9â package insert.

Case Report

A healthy 18-year-old male with no significant past medical or social history received dose number 3 of HPV vaccine at his physician’s office.   Within 24 hours, he developed chills and a fever (normal HPV reactions) and then recovered without sequelae within 48 hours.  Three days later, he developed crushing chest pain, with arm tingling and jaw pain.  He was triaged directly to the emergency room where he had troponins of greater than 11000 and T wave inversions on his EKG.  Other diagnostic tests and labs showed normal heart anatomy and no early coronary artery disease.  He was diagnosed with myopericarditis by cardiology.  He was treated and recovered fully within 3 months.


Using the WHO tool for adverse vaccine reactions, this case has a consistent causal relationship with vaccination.  This is the eleventh case of myopericarditis reported to the Vaccine Adverse Effects Reporting system for the HPV vaccine. 


Although rare, myopericarditis should be considered as a possible adverse effect from the human papillomavirus vaccine.

Article Details

How to Cite
PEGRAM, Angela H; BUSH, Tara V. A Case of Myopericarditis and the HPV vaccine. Medical Research Archives, [S.l.], v. 9, n. 12, dec. 2021. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/2649>. Date accessed: 17 jan. 2022. doi: https://doi.org/10.18103/mra.v9i12.2649.
Case Reports


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