Energy Drinks; Impact of Use in Patients with Diabetes, Obesity, and/or other Cardiometabolic Spectrum Conditions.
Main Article Content
Abstract
Energy drinks (EDs) are a brand of non-alcoholic beverages that are typically distinguished from regular sweetened caloric beverages (SCBs) by their augmented carbohydrate and purine alkaloids/methylxanthines (usually either caffeine; 1,3,7 trimethylxanthine and/or theobromine; 3,7 dimethylxanthine) content touted as being able to boost energy levels. At initial inception they were dominantly consumed by young adults (with an initial strong male preponderance) but in the last few decades as their variety, main-stream acceptance and widespread marketing has increased their appeal and consumption has become widespread and virtually universal to the general population including virtually all age, gender and ethno-racial demographics. With increased widespread consumption concerns regarding their safety and potential impact on long term health have started being raised. This is particularly pertinent as their regulatory oversight and monitoring is often presently minimal.
Diabetes and Obesity represent two dominant halves of the global diabesity epidemic that afflicts over 650 million adults worldwide with over 40% of the adult population in the United States affected. The well documented cardiometabolic spectrum (CMS) of diseases that are associated comorbidities of diabesity are well documented and it is inevitable that the increasing consumption of EDs would involve these group of persons in adult, geriatric, adolescent and even pediatric populations.
This review summarizes and synthesizes the limited published data on the described and potential health impact of EDs use particularly in persons with and/or at risk for diabetes, obesity and other CMS diseases to make the case for need of more careful study, monitoring and scrutiny of the use of these beverages in these group of persons. After providing an overview of the history, epidemiology and major components of EDs we detail the major potential and reported systemic complications of their long-term intake especially in at risk populations discussing the modulating effects of genetics, present comorbidities and alcohol co-intake. The prominent roles of caffeine and carbohydrates in the potential poly-systemic effects of EDs and their reported toxidromes is also highlighted while acknowledging the limitations in the present body of published data in this area.
Keywords:
Energy drinks, Sweetened Caloric beverages, Alcoholic beverages, Diabetes Mellitus, Obesity, Cardiometabolic syndrome, Caffeine
Article Details
How to Cite
MORAN, Heberth et al.
Energy Drinks; Impact of Use in Patients with Diabetes, Obesity, and/or other Cardiometabolic Spectrum Conditions..
Medical Research Archives, [S.l.], v. 10, n. 2, feb. 2022.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/2679>. Date accessed: 25 apr. 2024.
doi: https://doi.org/10.18103/mra.v10i2.2679.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
References
1. Ibrahim NK, Iftikhar R. Energy drinks: Getting wings but at what health cost? Pakistan journal of medical sciences. Nov-Dec 2014;30(6):1415-1419.
2. Alsunni AA. Energy Drink Consumption: Beneficial and Adverse Health Effects. International journal of health sciences. Oct 2015;9(4):468-474.
3. Top 50 most popular Energy drinks. 2021; https://www.nutritionix.com/grocery/category/soda/energy-drink/244. Accessed 12/12/2021, 2021.
4. Bizvibe. https://blog.bizvibe.com/blog/largest-energy-drink-brands. In: Bizvibe, ed. Vol 20212021.
5. Foster J. Top Selling Energy Drink Brands. 2021; https://www.caffeineinformer.com/the-15-top-energy-drink-brands. Accessed 12/12/2021, 2021.
6. Miller C, Ettridge K, Wakefield M, et al. Consumption of Sugar-Sweetened Beverages, Juice, Artificially-Sweetened Soda and Bottled Water: An Australian Population Study. Nutrients. Mar 19 2020;12(3).
7. Sorkin BC, Camp KM, Haggans CJ, et al. Executive summary of NIH workshop on the Use and Biology of Energy Drinks: Current Knowledge and Critical Gaps. Nutrition reviews. Oct 2014;72 Suppl 1:1-8.
8. Adams J, Hofman K, Moubarac JC, Thow AM. Public health response to ultra-processed food and drinks. BMJ. Jun 26 2020;369:m2391.
9. Bonfiglioli C, Hattersley L, King L. Australian print news media coverage of sweet, non-alcoholic drinks sends mixed health messages. Aust N Z J Public Health. Aug 2011;35(4):325-330.
10. Collins B, Capewell S, O'Flaherty M, et al. Modelling the Health Impact of an English Sugary Drinks Duty at National and Local Levels. PloS one. 2015;10(6):e0130770.
11. Datta BK, Husain MJ. Carbonating the household diet: a Pakistani tale. Public health nutrition. Jun 2020;23(9):1629-1637.
12. Fidler Mis N, Braegger C, Bronsky J, et al. Sugar in Infants, Children and Adolescents: A Position Paper of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition. J Pediatr Gastroenterol Nutr. Dec 2017;65(6):681-696.
13. Gupta P, Shah D, Kumar P, et al. Indian Academy of Pediatrics Guidelines on the Fast and Junk Foods, Sugar Sweetened Beverages, Fruit Juices, and Energy Drinks. Indian pediatrics. Oct 15 2019;56(10):849-863.
14. Gutierrez-Hellin J, Varillas-Delgado D. Energy Drinks and Sports Performance, Cardiovascular Risk, and Genetic Associations; Future Prospects. Nutrients. Feb 24 2021;13(3).
15. Lasater G, Piernas C, Popkin BM. Beverage patterns and trends among school-aged children in the US, 1989-2008. Nutrition journal. Oct 2 2011;10:103.
16. Mackus M, van de Loo A, Benson S, Scholey A, Verster JC. Consumption of caffeinated beverages and the awareness of their caffeine content among Dutch students. Appetite. Aug 1 2016;103:353-357.
17. Seifert SM, Schaechter JL, Hershorin ER, Lipshultz SE. Health effects of energy drinks on children, adolescents, and young adults. Pediatrics. Mar 2011;127(3):511-528.
18. Pabayo R, Spence JC, Casey L, Storey K. Food consumption patterns in preschool children. Canadian journal of dietetic practice and research : a publication of Dietitians of Canada = Revue canadienne de la pratique et de la recherche en dietetique : une publication des Dietetistes du Canada. Summer 2012;73(2):66-71.
19. Pabayo R, Spence JC, Cutumisu N, Casey L, Storey K. Sociodemographic, behavioural and environmental correlates of sweetened beverage consumption among pre-school children. Public health nutrition. Aug 2012;15(8):1338-1346.
20. Higgins JP, Tuttle TD, Higgins CL. Energy beverages: content and safety. Mayo Clinic proceedings. Nov 2010;85(11):1033-1041.
21. Higgins PB, Bastarrachea RA, Lopez-Alvarenga JC, et al. Eight week exposure to a high sugar high fat diet results in adiposity gain and alterations in metabolic biomarkers in baboons (Papio hamadryas sp.). Cardiovascular diabetology. Oct 29 2010;9:71.
22. Mansour B, Amarah W, Nasralla E, Elias N. Energy drinks in children and adolescents: demographic data and immediate effects. Eur J Pediatr. May 2019;178(5):649-656.
23. Bell RA, Mayer-Davis EJ, Martin MA, D'Agostino RB, Jr., Haffner SM. Associations between alcohol consumption and insulin sensitivity and cardiovascular disease risk factors: the Insulin Resistance and Atherosclerosis Study. Diabetes care. Nov 2000;23(11):1630-1636.
24. Di Minno MN, Franchini M, Russolillo A, Lupoli R, Iervolino S, Di Minno G. Alcohol dosing and the heart: updating clinical evidence. Semin Thromb Hemost. Nov 2011;37(8):875-884.
25. Djousse L, Arnett DK, Eckfeldt JH, Province MA, Singer MR, Ellison RC. Alcohol consumption and metabolic syndrome: does the type of beverage matter? Obes Res. Sep 2004;12(9):1375-1385.
26. Hu EA, Lazo M, Rosenberg SD, et al. Alcohol Consumption and Incident Kidney Disease: Results From the Atherosclerosis Risk in Communities Study. J Ren Nutr. Jan 2020;30(1):22-30.
27. Martz ME, Patrick ME, Schulenberg JE. Alcohol mixed with energy drink use among u.s. 12th-grade students: prevalence, correlates, and associations with unsafe driving. The Journal of adolescent health : official publication of the Society for Adolescent Medicine. May 2015;56(5):557-563.
28. Powers G, Berger L. Alcohol mixed with energy drinks: Expectancies of use and alcohol-related negative consequences among a young adult sample. Addictive behaviors reports. Dec 2020;12:100292.
29. Tucker JS, Troxel WM, Ewing BA, D'Amico EJ. Alcohol mixed with energy drinks: Associations with risky drinking and functioning in high school. Drug and alcohol dependence. Oct 1 2016;167:36-41.
30. Verster JC, Benson S, Johnson SJ, Scholey A, Alford C. Mixing alcohol with energy drink (AMED) and total alcohol consumption: a systematic review and meta-analysis. Human psychopharmacology. Jan 2016;31(1):2-10.
31. Hayes SL, Mann MK, Morgan FM, Kelly MJ, Weightman AL. Collaboration between local health and local government agencies for health improvement. The Cochrane database of systematic reviews. Oct 17 2012;10:CD007825.
32. Marczinski CA. Can energy drinks increase the desire for more alcohol? Advances in nutrition. Jan 2015;6(1):96-101.
33. Marczinski CA, Fillmore MT. Energy drinks mixed with alcohol: what are the risks? Nutrition reviews. Oct 2014;72 Suppl 1:98-107.
34. Marczinski CA, Stamates AL, Ossege J, Maloney SF, Bardgett ME, Brown CJ. Subjective State, Blood Pressure, and Behavioral Control Changes Produced by an "Energy Shot". Journal of caffeine research. Jun 1 2014;4(2):57-63.
35. Takechi R, Mamo J, Das S, et al. Short-term consumption of alcohol (vodka) mixed with energy drink (AMED) attenuated alcohol-induced cerebral capillary disturbances and neuroinflammation in adult wild-type mice. Nutritional neuroscience. Sep 22 2021:1-10.
36. Marczinski CA. Alcohol mixed with energy drinks: consumption patterns and motivations for use in U.S. college students. International journal of environmental research and public health. Aug 2011;8(8):3232-3245.
37. Marczinski CA, Fillmore MT, Bardgett ME, Howard MA. Effects of energy drinks mixed with alcohol on behavioral control: risks for college students consuming trendy cocktails. Alcoholism, clinical and experimental research. Jul 2011;35(7):1282-1292.
38. Marczinski CA, Fillmore MT, Henges AL, Ramsey MA, Young CR. Effects of energy drinks mixed with alcohol on information processing, motor coordination and subjective reports of intoxication. Experimental and clinical psychopharmacology. Apr 2012;20(2):129-138.
39. O'Brien MC, McCoy TP, Rhodes SD, Wagoner A, Wolfson M. Caffeinated cocktails: energy drink consumption, high-risk drinking, and alcohol-related consequences among college students. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. May 2008;15(5):453-460.
40. de Haan L, de Haan HA, van der Palen J, Olivier B, Verster JC. Effects of consuming alcohol mixed with energy drinks versus consuming alcohol only on overall alcohol consumption and negative alcohol-related consequences. International journal of general medicine. 2012;5:953-960.
41. Berger LK, Fendrich M, Chen HY, Arria AM, Cisler RA. Sociodemographic correlates of energy drink consumption with and without alcohol: results of a community survey. Addictive behaviors. May 2011;36(5):516-519.
42. Khan MR, Berger AT, Wells BE, Cleland CM. Longitudinal associations between adolescent alcohol use and adulthood sexual risk behavior and sexually transmitted infection in the United States: assessment of differences by race. American journal of public health. May 2012;102(5):867-876.
43. Arria AM, Caldeira KM, Kasperski SJ, et al. Increased alcohol consumption, nonmedical prescription drug use, and illicit drug use are associated with energy drink consumption among college students. Journal of addiction medicine. Jun 2010;4(2):74-80.
44. Arria AM, Caldeira KM, Kasperski SJ, Vincent KB, Griffiths RR, O'Grady KE. Energy drink consumption and increased risk for alcohol dependence. Alcoholism, clinical and experimental research. Feb 2011;35(2):365-375.
45. Attila S, Cakir B. Energy-drink consumption in college students and associated factors. Nutrition. Mar 2011;27(3):316-322.
46. Brache K, Stockwell T. Drinking patterns and risk behaviors associated with combined alcohol and energy drink consumption in college drinkers. Addictive behaviors. Dec 2011;36(12):1133-1140.
47. Cheng WJ, Cheng Y, Huang MC, Chen CJ. Alcohol dependence, consumption of alcoholic energy drinks and associated work characteristics in the Taiwan working population. Alcohol and alcoholism. Jul-Aug 2012;47(4):372-379.
48. Eckschmidt F, de Andrade AG, dos Santos B, de Oliveira LG. The effects of alcohol mixed with energy drinks (AmED) on traffic behaviors among Brazilian college students: a national survey. Traffic injury prevention. 2013;14(7):671-679.
49. Price SR, Hilchey CA, Darredeau C, Fulton HG, Barrett SP. Energy drink co-administration is associated with increased reported alcohol ingestion. Drug and alcohol review. May 2010;29(3):331-333.
50. Snipes DJ, Benotsch EG. High-risk cocktails and high-risk sex: examining the relation between alcohol mixed with energy drink consumption, sexual behavior, and drug use in college students. Addictive behaviors. Jan 2013;38(1):1418-1423.
51. Snipes DJ, Green BA, Javier SJ, Perrin PB, Benotsch EG. The use of alcohol mixed with energy drinks and experiences of sexual victimization among male and female college students. Addictive behaviors. Jan 2014;39(1):259-264.
52. Berger L, Fendrich M, Fuhrmann D. Alcohol mixed with energy drinks: are there associated negative consequences beyond hazardous drinking in college students? Addictive behaviors. Sep 2013;38(9):2428-2432.
53. Jacobson BH, Hughes PP, Conchola EC, Hester GM, Woolsey CL. Effect of Energy Drinks on Selected Fine Motor Tasks. Perceptual and motor skills. Aug 2015;121(1):170-178.
54. Miller KE. Alcohol Mixed with Energy Drink Use and Sexual Risk-Taking: Casual, Intoxicated, and Unprotected Sex. Journal of caffeine research. Jun 2012;2(2):62-69.
55. Sather TE, Woolsey CL, Williams RD, Jr., Evans MW, Jr., Cromartie F. Age of first use of energy beverages predicts future maximal consumption among naval pilot and flight officer candidates. Addictive behaviors reports. Jun 2016;3:9-13.
56. Woolsey CL, Jacobson BH, Williams RD, Jr., et al. A comparison of the combined-use of alcohol & energy drinks to alcohol-only on high-risk drinking and driving behaviors. Substance use & misuse. Jan 2015;50(1):1-7.
57. Woolsey CL, Williams RD, Jr., Housman JM, Barry AE, Jacobson BH, Evans MW, Jr. Combined Use of Alcohol and Energy Drinks Increases Participation in High-Risk Drinking and Driving Behaviors Among College Students. Journal of studies on alcohol and drugs. Jul 2015;76(4):615-619.
58. Woolsey CL, Williams RD, Jr., Jacobson BH, et al. Increased Energy Drink Use as a Predictor of Illicit Prescription Stimulant Use. Substance abuse. 2015;36(4):413-419.
59. de Haan L, Egberts AC, Heerdink ER. The relation between risk-taking behavior and alcohol use in young adults is different for men and women. Drug and alcohol dependence. Oct 1 2015;155:222-227.
60. Writing Group M, Mozaffarian D, Benjamin EJ, et al. Executive Summary: Heart Disease and Stroke Statistics--2016 Update: A Report From the American Heart Association. Circulation. Jan 26 2016;133(4):447-454.
61. Writing Group M, Mozaffarian D, Benjamin EJ, et al. Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association. Circulation. Jan 26 2016;133(4):e38-360.
62. Olateju T, Begley J, Green DJ, Kerr D. Physiological and glycemic responses following acute ingestion of a popular functional drink in patients with type 1 diabetes. Can J Diabetes. Feb 2015;39(1):78-82.
63. Trapp G, Hurworth M, Jacoby P, et al. Energy drink intake and metabolic syndrome: A prospective investigation in young adults. Nutr Metab Cardiovasc Dis. Sep 24 2020;30(10):1679-1684.
64. England CY, Andrews R, Jago R, Thompson JL. Changes in reported food intake in adults with type 2 diabetes in response to a nonprescriptive dietary intervention. Journal of human nutrition and dietetics : the official journal of the British Dietetic Association. Aug 2014;27(4):311-321.
65. Evans CEL. Sugars and health: a review of current evidence and future policy. Proc Nutr Soc. Aug 2017;76(3):400-407.
66. Yong HY, Mohd Shariff Z, Mohd Yusof BN, et al. Beverage Intake and the Risk of Gestational Diabetes Mellitus: The SECOST. Nutrients. Jun 27 2021;13(7).
67. Yu R, Woo J, Chan R, et al. Relationship between dietary intake and the development of type 2 diabetes in a Chinese population: the Hong Kong Dietary Survey. Public health nutrition. Jul 2011;14(7):1133-1141.
68. Zaparolli MR, MRR DA-C, Frehner C, et al. Food Intake Evaluation during the First Year of Postoperative of Patients with Type 2 Diabetes Mellitus or Glycemic Alteration Submitted to Roux-En-Y Gastric Bypass. Arq Bras Cir Dig. 2018;31(2):e1367.
69. (NIDDK) NIoDaDaKD. Diabetes Statistics. 2021; https://www.niddk.nih.gov/health-information/health-statistics/diabetes-statistics.
70. prevention. USDoHaHSCfDca. National Diabetes Statistics Report 2020; Estimates of Diabetes and Its Burden in the United States. 2020; https://www.cdc.gov/diabetes/pdfs/data/statistics/national-diabetes-statistics-report.pdf.
71. Shah NS, Wang MC, Freaney PM, et al. Trends in Gestational Diabetes at First Live Birth by Race and Ethnicity in the US, 2011-2019. Jama. Aug 17 2021;326(7):660-669.
72. Wang J, Luben R, Khaw KT, Bingham S, Wareham NJ, Forouhi NG. Dietary energy density predicts the risk of incident type 2 diabetes: the European Prospective Investigation of Cancer (EPIC)-Norfolk Study. Diabetes care. Nov 2008;31(11):2120-2125.
73. Wang L, Li X, Wang Z, et al. Trends in Prevalence of Diabetes and Control of Risk Factors in Diabetes Among US Adults, 1999-2018. Jama. Jun 25 2021.
74. Saran R, Li Y, Robinson B, et al. US Renal Data System 2014 Annual Data Report: Epidemiology of Kidney Disease in the United States. American journal of kidney diseases : the official journal of the National Kidney Foundation. Jul 2015;66(1 Suppl 1):Svii, S1-305.
75. Burt VL, Cutler JA, Higgins M, et al. Trends in the prevalence, awareness, treatment, and control of hypertension in the adult US population. Data from the health examination surveys, 1960 to 1991. Hypertension. Jul 1995;26(1):60-69.
76. Burt VL, Whelton P, Roccella EJ, et al. Prevalence of hypertension in the US adult population. Results from the Third National Health and Nutrition Examination Survey, 1988-1991. Hypertension. Mar 1995;25(3):305-313.
77. Egan BM. The prevalence and control of hypertension in adults. 2021; https://www.uptodate.com/contents/the-prevalence-and-control-of-hypertension-in-adults.
78. Ostchega Y, Fryar CD, Nwankwo T, Nguyen DT. Hypertension Prevalence Among Adults Aged 18 and Over: United States, 2017-2018. NCHS data brief. Apr 2020(364):1-8.
79. Prevention. CfDCa. High blood pressure; Facts about hypertension. 2021; https://www.cdc.gov/bloodpressure/facts.htm.
80. Audain K, Levy L, Ellahi B. Sugar-sweetened beverage consumption in the early years and implications for type-2 diabetes: a sub-Saharan Africa context. Proc Nutr Soc. Nov 2019;78(4):547-553.
81. Ballard SL, Wellborn-Kim JJ, Clauson KA. Effects of commercial energy drink consumption on athletic performance and body composition. The Physician and sportsmedicine. Apr 2010;38(1):107-117.
82. Basrai M, Schweinlin A, Menzel J, et al. Energy Drinks Induce Acute Cardiovascular and Metabolic Changes Pointing to Potential Risks for Young Adults: A Randomized Controlled Trial. The Journal of nutrition. Mar 1 2019;149(3):441-450.
83. Berg CM, Lappas G, Strandhagen E, et al. Food patterns and cardiovascular disease risk factors: the Swedish INTERGENE research program. The American journal of clinical nutrition. Aug 2008;88(2):289-297.
84. Chrysant SG, Chrysant GS. Cardiovascular complications from consumption of high energy drinks: recent evidence. J Hum Hypertens. Feb 2015;29(2):71-76.
85. de Koning L, Malik VS, Rimm EB, Willett WC, Hu FB. Sugar-sweetened and artificially sweetened beverage consumption and risk of type 2 diabetes in men. The American journal of clinical nutrition. Jun 2011;93(6):1321-1327.
86. Dhingra R, Sullivan L, Jacques PF, et al. Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community. Circulation. Jul 31 2007;116(5):480-488.
87. Dominguez LJ, Martinez-Gonzalez MA, Basterra-Gortari FJ, Gea A, Barbagallo M, Bes-Rastrollo M. Fast food consumption and gestational diabetes incidence in the SUN project. PloS one. 2014;9(9):e106627.
88. Donazar-Ezcurra M, Lopez-Del Burgo C, Martinez-Gonzalez MA, Basterra-Gortari FJ, de Irala J, Bes-Rastrollo M. Soft drink consumption and gestational diabetes risk in the SUN project. Clinical nutrition. Apr 2018;37(2):638-645.
89. Duchan E, Patel ND, Feucht C. Energy drinks: a review of use and safety for athletes. The Physician and sportsmedicine. Jun 2010;38(2):171-179.
90. Fisk G, Hammond-Haley M, D'Silva A. Energy drink-induced cardiomyopathy. BMJ Case Rep. Apr 15 2021;14(4).
91. Gharacholou SM, Ijioma N, Banwart E, Munoz FD. ST-Segment Elevation Myocardial Infarction and Normal Coronary Arteries after Consuming Energy Drinks. Case Rep Cardiol. 2017;2017:4061205.
92. Graneri LT, Mamo JCL, D'Alonzo Z, Lam V, Takechi R. Chronic Intake of Energy Drinks and Their Sugar Free Substitution Similarly Promotes Metabolic Syndrome. Nutrients. Apr 6 2021;13(4).
93. Hu FB, Malik VS. Sugar-sweetened beverages and risk of obesity and type 2 diabetes: epidemiologic evidence. Physiology & behavior. Apr 26 2010;100(1):47-54.
94. Kaminer Y. Problematic use of energy drinks by adolescents. Child and adolescent psychiatric clinics of North America. Jul 2010;19(3):643-650.
95. Malik VS, Popkin BM, Bray GA, Despres JP, Willett WC, Hu FB. Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis. Diabetes care. Nov 2010;33(11):2477-2483.
96. Nguyen S, Choi HK, Lustig RH, Hsu CY. Sugar-sweetened beverages, serum uric acid, and blood pressure in adolescents. J Pediatr. Jun 2009;154(6):807-813.
97. Niemczyk M, Stopa M, Lobacz M, Rutkowska K, Radko A. Influence of energy drinks on hemodynamic parameters in young healthy adults - Randomized double-blind placebo controlled cross-over study: PS020. Porto Biomed J. Sep-Oct 2017;2(5):199.
98. Paglia L. The sweet danger of added sugars. Eur J Paediatr Dent. Jun 2019;20(2):89.
99. Pase MP, Himali JJ, Beiser AS, et al. Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia: A Prospective Cohort Study. Stroke. May 2017;48(5):1139-1146.
100. Robin S, Buchanan R, Poole R. Energy drinks and adolescents - A hepatic health hazard? J Hepatol. Apr 2018;68(4):856-857.
101. Roeb E, Weiskirchen R. Fructose and Non-Alcoholic Steatohepatitis. Front Pharmacol. 2021;12:634344.
102. Shah SA, Chu BW, Lacey CS, Riddock IC, Lee M, Dargush AE. Impact of Acute Energy Drink Consumption on Blood Pressure Parameters: A Meta-analysis. Ann Pharmacother. Oct 2016;50(10):808-815.
103. Shin S, Kim SA, Ha J, Lim K. Sugar-Sweetened Beverage Consumption in Relation to Obesity and Metabolic Syndrome among Korean Adults: A Cross-Sectional Study from the 2012(-)2016 Korean National Health and Nutrition Examination Survey (KNHANES). Nutrients. Oct 9 2018;10(10).
104. Shoham DA, Durazo-Arvizu R, Kramer H, et al. Sugary soda consumption and albuminuria: results from the National Health and Nutrition Examination Survey, 1999-2004. PloS one. 2008;3(10):e3431.
105. Voskoboinik A, Koh Y, Kistler PM. Cardiovascular effects of caffeinated beverages. Trends Cardiovasc Med. Aug 2019;29(6):345-350.
106. Wikoff D, Welsh BT, Henderson R, et al. Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. Nov 2017;109(Pt 1):585-648.
107. Butt MS, Sultan MT. Coffee and its consumption: benefits and risks. Critical reviews in food science and nutrition. Apr 2011;51(4):363-373.
108. van Dam RM. Coffee consumption and risk of type 2 diabetes, cardiovascular diseases, and cancer. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. Dec 2008;33(6):1269-1283.
109. Cornelis MC, El-Sohemy A, Campos H. Genetic polymorphism of the adenosine A2A receptor is associated with habitual caffeine consumption. The American journal of clinical nutrition. Jul 2007;86(1):240-244.
110. Laitala VS, Kaprio J, Silventoinen K. Genetics of coffee consumption and its stability. Addiction. Dec 2008;103(12):2054-2061.
111. Yang A, Palmer AA, de Wit H. Genetics of caffeine consumption and responses to caffeine. Psychopharmacology. Aug 2010;211(3):245-257.
112. Drucker DJ. Incretin action in the pancreas: potential promise, possible perils, and pathological pitfalls. Diabetes. Oct 2013;62(10):3316-3323.
113. Hussein GM, Matsuda H, Nakamura S, et al. Mate tea (Ilex paraguariensis) promotes satiety and body weight lowering in mice: involvement of glucagon-like peptide-1. Biological & pharmaceutical bulletin. 2011;34(12):1849-1855.
114. Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Microbial ecology: human gut microbes associated with obesity. Nature. Dec 21 2006;444(7122):1022-1023.
115. Cowan TE, Palmnas MS, Yang J, et al. Chronic coffee consumption in the diet-induced obese rat: impact on gut microbiota and serum metabolomics. The Journal of nutritional biochemistry. Apr 2014;25(4):489-495.
116. Greenblum S, Turnbaugh PJ, Borenstein E. Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease. Proceedings of the National Academy of Sciences of the United States of America. Jan 10 2012;109(2):594-599.
117. Payne AN, Chassard C, Lacroix C. Gut microbial adaptation to dietary consumption of fructose, artificial sweeteners and sugar alcohols: implications for host-microbe interactions contributing to obesity. Obesity reviews : an official journal of the International Association for the Study of Obesity. Sep 2012;13(9):799-809.
118. Administration USFaD. Spilling the Beans: How Much Caffeine is Too Much? 2021; https://www.fda.gov/consumers/consumer-updates/spilling-beans-how-much-caffeine-too-much. Accessed 12/12/2021, 2021.
119. Heckman MA, Weil J, Gonzalez de Mejia E. Caffeine (1, 3, 7-trimethylxanthine) in foods: a comprehensive review on consumption, functionality, safety, and regulatory matters. Journal of food science. Apr 2010;75(3):R77-87.
120. Troxel WM, Tucker JS, Ewing B, Miles JNV, D'Amico EJ. Sleepy Teens and Energy Drink Use: Results From an Ethnically Diverse Sample of Youth. Behavioral sleep medicine. May-Jun 2018;16(3):223-234.
121. Willson C. The clinical toxicology of caffeine: A review and case study. Toxicology reports. 2018;5:1140-1152.
122. Cappelletti S, Piacentino D, Fineschi V, Frati P, Cipolloni L, Aromatario M. Caffeine-Related Deaths: Manner of Deaths and Categories at Risk. Nutrients. May 14 2018;10(5).
123. Osswald H, Schnermann J. Methylxanthines and the kidney. Handbook of experimental pharmacology. 2011(200):391-412.
124. Willson C. Sympathomimetic amine compounds and hepatotoxicity: Not all are alike-Key distinctions noted in a short review. Toxicology reports. 2019;6:26-33.
125. Sorkin BC, Coates PM. Caffeine-containing energy drinks: beginning to address the gaps in what we know. Advances in nutrition. Sep 2014;5(5):541-543.
126. Trabulo D, Marques S, Pedroso E. Caffeinated energy drink intoxication. BMJ Case Rep. Feb 2 2011;2011.
127. Choudhury TR, Abdool MA, Galasko G. Energy drinks give you wings but also an abnormal exercise test. BMJ Case Rep. Jul 27 2017;2017.
128. Mahmud A, Feely J. Acute effect of caffeine on arterial stiffness and aortic pressure waveform. Hypertension. Aug 2001;38(2):227-231.
129. Bkaily G, Jazzar A, Normand A, Simon Y, Al-Khoury J, Jacques D. Taurine and cardiac disease: state of the art and perspectives. Can J Physiol Pharmacol. Feb 2020;98(2):67-73.
130. Wojcik OP, Koenig KL, Zeleniuch-Jacquotte A, Costa M, Chen Y. The potential protective effects of taurine on coronary heart disease. Atherosclerosis. Jan 2010;208(1):19-25.
131. Seidl R, Peyrl A, Nicham R, Hauser E. A taurine and caffeine-containing drink stimulates cognitive performance and well-being. Amino acids. 2000;19(3-4):635-642.
132. Boasquivis PF, Silva GMM, Paiva FA, Cavalcanti RM, Nunez CV, de Paula Oliveira R. Guarana (Paullinia cupana) Extract Protects Caenorhabditis elegans Models for Alzheimer Disease and Huntington Disease through Activation of Antioxidant and Protein Degradation Pathways. Oxidative medicine and cellular longevity. 2018;2018:9241308.
133. Peixoto H, Roxo M, Rohrig T, Richling E, Wang X, Wink M. Anti-Aging and Antioxidant Potential of Paullinia cupana var. sorbilis: Findings in Caenorhabditis elegans Indicate a New Utilization for Roasted Seeds of Guarana. Medicines. Aug 15 2017;4(3).
134. Schimpl FC, da Silva JF, Goncalves JF, Mazzafera P. Guarana: revisiting a highly caffeinated plant from the Amazon. Journal of ethnopharmacology. Oct 28 2013;150(1):14-31.
135. Zeidan-Chulia F, Gelain DP, Kolling EA, et al. Major components of energy drinks (caffeine, taurine, and guarana) exert cytotoxic effects on human neuronal SH-SY5Y cells by decreasing reactive oxygen species production. Oxidative medicine and cellular longevity. 2013;2013:791795.
136. Woods DJ. Guarana: Paullinia cupana, P. sorbilis; also known as Brazilian cocoa and 'zoom'. Journal of primary health care. Jun 1 2012;4(2):163-164.
137. Smith N, Atroch AL. Guarana's Journey from Regional Tonic to Aphrodisiac and Global Energy Drink. Evidence-based complementary and alternative medicine : eCAM. Sep 2010;7(3):279-282.
138. Moustakas D, Mezzio M, Rodriguez BR, Constable MA, Mulligan ME, Voura EB. Guarana provides additional stimulation over caffeine alone in the planarian model. PloS one. 2015;10(4):e0123310.
139. Boyina R, Dodoala S. Evaluation of the Neurobehavioural Toxic Effects of Taurine, Glucuronolactone, and Gluconolactone Used in Energy Drinks in Young Rats. Turkish journal of pharmaceutical sciences. Dec 23 2020;17(6):659-666.
140. McLellan TM, Lieberman HR. Do energy drinks contain active components other than caffeine? Nutrition reviews. Dec 2012;70(12):730-744.
141. Miles-Chan JL, Charriere N, Grasser EK, Montani JP, Dulloo AG. The thermic effect of sugar-free Red Bull: do the non-caffeine bioactive ingredients in energy drinks play a role? Obesity. Jan 2015;23(1):16-19.
142. Ricciutelli M, Caprioli G, Cortese M, et al. Simultaneous determination of taurine, glucuronolactone and glucuronic acid in energy drinks by ultra high performance liquid chromatography-tandem mass spectrometry (triple quadrupole). Journal of chromatography. A. Oct 17 2014;1364:303-307.
143. Abenavoli L, Capasso R, Milic N, Capasso F. Milk thistle in liver diseases: past, present, future. Phytotherapy research : PTR. Oct 2010;24(10):1423-1432.
144. Albassam AA, Frye RF, Markowitz JS. The effect of milk thistle (Silybum marianum) and its main flavonolignans on CYP2C8 enzyme activity in human liver microsomes. Chemico-biological interactions. Jun 1 2017;271:24-29.
145. Bray GA. Fructose: pure, white, and deadly? Fructose, by any other name, is a health hazard. J Diabetes Sci Technol. Jul 1 2010;4(4):1003-1007.
146. Bray GA. Energy and fructose from beverages sweetened with sugar or high-fructose corn syrup pose a health risk for some people. Advances in nutrition. Mar 1 2013;4(2):220-225.
147. Bray GA, Popkin BM. Dietary sugar and body weight: have we reached a crisis in the epidemic of obesity and diabetes?: health be damned! Pour on the sugar. Diabetes care. Apr 2014;37(4):950-956.
148. Vos MB, Lavine JE. Dietary fructose in nonalcoholic fatty liver disease. Hepatology. Jun 2013;57(6):2525-2531.
149. Bray GA. Fructose: should we worry? International journal of obesity. Dec 2008;32 Suppl 7:S127-131.
150. DeChristopher LR, Tucker KL. Excess free fructose, high-fructose corn syrup and adult asthma: the Framingham Offspring Cohort. The British journal of nutrition. May 2018;119(10):1157-1167.
151. DeChristopher LR, Uribarri J, Tucker KL. Intake of high fructose corn syrup sweetened soft drinks, fruit drinks and apple juice is associated with prevalent coronary heart disease, in U.S. adults, ages 45-59 y. BMC Nutr. 2017;3:51.
152. Ferder L, Ferder MD, Inserra F. The role of high-fructose corn syrup in metabolic syndrome and hypertension. Curr Hypertens Rep. Apr 2010;12(2):105-112.
153. Saeed SA, Hameed A, Yousif S, Lessan N. The perils of high carbohydrate drinks in the undiagnosed diabetic patient. BMJ Case Rep. Aug 11 2011;2011.
154. Stricker S, Rudloff S, Geier A, Steveling A, Roeb E, Zimmer KP. Fructose Consumption-Free Sugars and Their Health Effects. Dtsch Arztebl Int. Feb 5 2021;118(5):71-78.
155. Taskinen MR, Packard CJ, Boren J. Dietary Fructose and the Metabolic Syndrome. Nutrients. Aug 22 2019;11(9).
156. den Biggelaar L, Sep SJS, Mari A, et al. Association of artificially sweetened and sugar-sweetened soft drinks with beta-cell function, insulin sensitivity, and type 2 diabetes: the Maastricht Study. European journal of nutrition. Jun 2020;59(4):1717-1727.
157. Omran A, Ahearn G, Bowers D, Swenson J, Coughlin C. Metabolic effects of sucralose on environmental bacteria. Journal of toxicology. 2013;2013:372986.
158. Omran A, Baker R, Coughlin C. Differential bacteriostatic effects of sucralose on various species of environmental bacteria. ISRN toxicology. 2013;2013:415070.
159. AlDeeb OA, Mahgoub H, Foda NH. Sucralose. Profiles of drug substances, excipients, and related methodology. 2013;38:423-462.
160. Carlomagno G, Unfer V. Inositol safety: clinical evidences. European review for medical and pharmacological sciences. Aug 2011;15(8):931-936.
161. Hofman DL, van Buul VJ, Brouns FJ. Nutrition, Health, and Regulatory Aspects of Digestible Maltodextrins. Critical reviews in food science and nutrition. Sep 9 2016;56(12):2091-2100.
162. Shishtar E, Jovanovski E, Jenkins A, Vuksan V. Effects of Korean White Ginseng (Panax Ginseng C.A. Meyer) on Vascular and Glycemic Health in Type 2 Diabetes: Results of a Randomized, Double Blind, Placebo-controlled, Multiple-crossover, Acute Dose Escalation Trial. Clinical nutrition research. Jul 2014;3(2):89-97.
163. Shishtar E, Sievenpiper JL, Djedovic V, et al. The effect of ginseng (the genus panax) on glycemic control: a systematic review and meta-analysis of randomized controlled clinical trials. PloS one. 2014;9(9):e107391.
164. Diamond BJ, Bailey MR. Ginkgo biloba: indications, mechanisms, and safety. The Psychiatric clinics of North America. Mar 2013;36(1):73-83.
165. Shannon CE, Nixon AV, Greenhaff PL, Stephens FB. Protein ingestion acutely inhibits insulin-stimulated muscle carnitine uptake in healthy young men. The American journal of clinical nutrition. Jan 2016;103(1):276-282.
166. Heckman MA, Sherry K, De Mejia EG. Energy Drinks: An Assessment of Their Market Size, Consumer Demographics, Ingredient Profile, Functionality, and Regulations in the United States. Comprehensive reviews in food science and food safety. May 2010;9(3):303-317.
167. Staff MC. Nutrition and Healthy Eating; Artificial sweetners and other sugar substitutes. 2020; https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/in-depth/artificial-sweeteners/art-20046936.
168. Wikipedia. Sugar Substitute. 2021; https://en.wikipedia.org/wiki/Sugar_substitute.
169. Salomon SH, Kennedy K. The 9 Best Sugar Substitutes for People With Type 2 Diabetes. 2019; https://www.everydayhealth.com/type-2-diabetes/diet/sugar-substitutes-for-diabetes/.
170. FDA US. How Sweet It Is: All About Sugar Substitutes. 2020; https://www.fda.gov/consumers/consumer-updates/how-sweet-it-all-about-sugar-substitutes.
171. Wax E, Zieve D, Conaway B, team ADAME. Sweeteners - sugar substitutes. 2019; https://medlineplus.gov/ency/article/007492.htm.
172. Graneri L, Lam V, D'Alonzo Z, Nesbit M, Mamo JCL, Takechi R. The Consumption of Energy Drinks Induces Blood-Brain Barrier Dysfunction in Wild-Type Mice. Frontiers in nutrition. 2021;8:668514.
173. Ruiz-Ojeda FJ, Plaza-Diaz J, Saez-Lara MJ, Gil A. Effects of Sweeteners on the Gut Microbiota: A Review of Experimental Studies and Clinical Trials. Advances in nutrition. Jan 1 2019;10(suppl_1):S31-S48.
174. Sandolu A, Robertson C. Coffee drinkers have healthier gut microbiotas. 2019; https://www.medicalnewstoday.com/articles/326845.
175. Alford C, Hamilton-Morris J, Verster JC. The effects of energy drink in combination with alcohol on performance and subjective awareness. Psychopharmacology. Aug 2012;222(3):519-532.
176. de Haan L, de Haan HA, Olivier B, Verster JC. Alcohol mixed with energy drinks: methodology and design of the Utrecht Student Survey. International journal of general medicine. 2012;5:889-898.
177. Verster JC, Alford C, Scholey A. The alcohol mixed with energy drink debate: masking the facts! A commentary on "Mixing an energy drink with an alcoholic beverage increases motivation for more alcohol in college students" by Marczinski and colleagues (in press). Alcoholism, clinical and experimental research. Apr 2013;37(4):703-705.
178. Verster JC, Aufricht C, Alford C. Energy drinks mixed with alcohol: misconceptions, myths, and facts. International journal of general medicine. 2012;5:187-198.
179. Howard AL, Patrick ME, Maggs JL. College student affect and heavy drinking: Variable associations across days, semesters, and people. Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors. Jun 2015;29(2):430-443.
180. Patrick ME, Evans-Polce RJ, Maggs JL. Use of alcohol mixed with energy drinks as a predictor of alcohol-related consequences two years later. Journal of studies on alcohol and drugs. Sep 2014;75(5):753-757.
181. Patrick ME, Maggs JL. Energy drinks and alcohol: links to alcohol behaviors and consequences across 56 days. The Journal of adolescent health : official publication of the Society for Adolescent Medicine. Apr 2014;54(4):454-459.
182. Dillon P, Kelpin S, Kendler K, Thacker L, Dick D, Svikis D. Gender Differences in Any-Source Caffeine and Energy Drink Use and Associated Adverse Health Behaviors. Journal of caffeine and adenosine research. Mar 1 2019;9(1):12-19.
183. Arnaud MJ. Pharmacokinetics and metabolism of natural methylxanthines in animal and man. Handbook of experimental pharmacology. 2011(200):33-91.
184. Brunner Y, Schvartz D, Priego-Capote F, Coute Y, Sanchez JC. Glucotoxicity and pancreatic proteomics. Journal of proteomics. Jan 30 2009;71(6):576-591.
185. Luo X, Wu J, Jing S, Yan LJ. Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity. Aging and disease. Jan 2016;7(1):90-110.
186. Mooradian AD, Thurman JE. Glucotoxicity: potential mechanisms. Clinics in geriatric medicine. May 1999;15(2):255.
187. Grasser EK, Miles-Chan JL, Charriere N, Loonam CR, Dulloo AG, Montani JP. Energy Drinks and Their Impact on the Cardiovascular System: Potential Mechanisms. Advances in nutrition. Sep 2016;7(5):950-960.
188. Iyer PS, Yelisetti R, Miriyala V, Siddiqui W, Kaji A. A remarkable case of rhabdomyolysis associated with ingestion of energy drink 'neon volt'. J Community Hosp Intern Med Perspect. 2016;6(5):32528.
189. Johnson RK, Appel LJ, Brands M, et al. Dietary sugars intake and cardiovascular health: a scientific statement from the American Heart Association. Circulation. Sep 15 2009;120(11):1011-1020.
190. Jonjev ZS, Bala G. High-energy drinks may provoke aortic dissection. Coll Antropol. May 2013;37 Suppl 2:227-229.
191. Kromann CB, Nielsen CT. A case of cola dependency in a woman with recurrent depression. BMC Res Notes. Dec 21 2012;5:692.
192. Solomin D, Borron SW, Watts SH. STEMI Associated with Overuse of Energy Drinks. Case Rep Emerg Med. 2015;2015:537689.
193. Tofield A. Energy drinks can cause heart problems. Eur Heart J. Mar 1 2015;36(9):537.
194. Usman A, Jawaid A. Hypertension in a young boy: an energy drink effect. BMC Res Notes. Oct 29 2012;5:591.
195. Uwaifo GI. Beware Energy Drinks: A Case of a Toxic Triad Syndrome in a Diabetic Patient With Nonalcoholic Fatty Liver Disease. Am J Med Sci. Oct 2019;358(4):304-311.
196. Belzile D, Cinq-Mars A, Bernier M, et al. Do Energy Drinks Really Give You Wings? Left Ventricular Assist Device Therapy as a Bridge to Recovery for an Energy Drink-Induced Cardiomyopathy. The Canadian journal of cardiology. Feb 2020;36(2):317 e311-317 e313.
197. Chung S, Ha K, Lee HS, et al. Soft drink consumption is positively associated with metabolic syndrome risk factors only in Korean women: Data from the 2007-2011 Korea National Health and Nutrition Examination Survey. Metabolism: clinical and experimental. Nov 2015;64(11):1477-1484.
198. Rebholz CM, Young BA, Katz R, et al. Patterns of Beverages Consumed and Risk of Incident Kidney Disease. Clin J Am Soc Nephrol. Jan 7 2019;14(1):49-56.
199. Stopa M, Lobacz M, Niemczyk M, et al. Influence of energy drinks on acute hemodynamic parameters in young healthy adults: a randomized double-blind placebo-controlled crossover pilot study. Kardiol Pol. Apr 24 2020;78(4):335-337.
200. Ward AE, Lipshultz SE, Fisher SD. Energy drink-induced near-fatal ventricular arrhythmia prevented by an intracardiac defibrillator decades after operative "repair" of tetralogy of Fallot. Am J Cardiol. Oct 1 2014;114(7):1124-1125.
201. Yuzbashian E, Asghari G, Mirmiran P, Zadeh-Vakili A, Azizi F. Sugar-sweetened beverage consumption and risk of incident chronic kidney disease: Tehran lipid and glucose study. Nephrology (Carlton). Jul 2016;21(7):608-616.
202. Zulli A, Smith RM, Kubatka P, et al. Caffeine and cardiovascular diseases: critical review of current research. European journal of nutrition. Jun 2016;55(4):1331-1343.
203. Benjo AM, Pineda AM, Nascimento FO, Zamora C, Lamas GA, Escolar E. Left main coronary artery acute thrombosis related to energy drink intake. Circulation. Mar 20 2012;125(11):1447-1448.
204. Dupasquier E, Bugnon A, Fellay G, Grbic M, Braaker P, Monney A. [Prinzmetal's angor. Apropos of 4 cases. Review of the literature]. Schweiz Med Wochenschr. Sep 27 1975;105(39):1246-1258.
205. Fujii W, Takaki M, Yoshida A, Ishidate H, Ito H, Suga H. Effects of intracoronary caffeine on left ventricular mechanoenergetics in Ca2+ overload failing rat hearts. Jpn J Physiol. Oct 1998;48(5):373-381.
206. Grasser EK, Yepuri G, Dulloo AG, Montani JP. Cardio- and cerebrovascular responses to the energy drink Red Bull in young adults: a randomized cross-over study. European journal of nutrition. Oct 2014;53(7):1561-1571.
207. Lasheras I, Seral P, Alonso-Ventura V, Santabarbara J. The impact of acute energy drink consumption on electrical heart disease: A systematic review and meta-analysis. Journal of electrocardiology. Mar-Apr 2021;65:128-135.
208. Howland J, Rohsenow DJ, Arnedt JT, et al. The acute effects of caffeinated versus non-caffeinated alcoholic beverage on driving performance and attention/reaction time. Addiction. Feb 2011;106(2):335-341.
209. Dikici S, Saritas A, Besir FH, Tasci AH, Kandis H. Do energy drinks cause epileptic seizure and ischemic stroke? The American journal of emergency medicine. Jan 2013;31(1):274 e271-274.
210. Saritas A, Dikici S, Gunes H. Adverse effects of energy drinks. The American journal of emergency medicine. Mar 2015;33(3):461-462.
211. InterAct C, Romaguera D, Norat T, et al. Consumption of sweet beverages and type 2 diabetes incidence in European adults: results from EPIC-InterAct. Diabetologia. Jul 2013;56(7):1520-1530.
212. Kong L, Lu Y, Zhang S, Nan Y, Qiao L. Role of nutrition, gene polymorphism, and gut microbiota in non-alcoholic fatty liver disease. Discovery medicine. Sep 2017;24(131):95-106.
213. Battaglin WA, Bradley PM, Iwanowicz L, Journey CA, Walsh HL, Blazer VS. Pharmaceuticals, hormones, pesticides, and other bioactive contaminants in water, sediment, and tissue from Rocky Mountain National Park, 2012-2013. The Science of the total environment. Dec 1 2018;643:651-673.
214. Furlong ET, Batt AL, Glassmeyer ST, et al. Nationwide reconnaissance of contaminants of emerging concern in source and treated drinking waters of the United States: Pharmaceuticals. The Science of the total environment. Feb 1 2017;579:1629-1642.
215. Ackah M, Anim AK, Zakaria N, et al. Determination of some heavy metal levels in soft drinks on the Ghanaian market using atomic absorption spectrometry method. Environmental monitoring and assessment. Dec 2014;186(12):8499-8507.
216. Gallo P, Di Marco Pisciottano I, Esposito F, et al. Determination of BPA, BPB, BPF, BADGE and BFDGE in canned energy drinks by molecularly imprinted polymer cleaning up and UPLC with fluorescence detection. Food chemistry. Apr 1 2017;220:406-412.
217. Izah SC, Inyang IR, Angaye TCN, Okowa IP. A Review of Heavy Metal Concentration and Potential Health Implications of Beverages Consumed in Nigeria. Toxics. Dec 22 2016;5(1).
218. Kilic S, Cengiz MF, Kilic M. Monitoring of metallic contaminants in energy drinks using ICP-MS. Environmental monitoring and assessment. Mar 9 2018;190(4):202.
219. Shruti VC, Perez-Guevara F, Elizalde-Martinez I, Kutralam-Muniasamy G. First study of its kind on the microplastic contamination of soft drinks, cold tea and energy drinks - Future research and environmental considerations. The Science of the total environment. Jul 15 2020;726:138580.
220. Wuthiekanun V, Amornchai P, Langla S, White NJ, Day NPJ, Limmathurotsakul D. Survival of Burkholderia pseudomallei and Pathogenic Leptospira in Cola, Beer, Energy Drinks, and Sports Drinks. The American journal of tropical medicine and hygiene. Jul 2020;103(1):249-252.
221. Intelligence M. AFRICA ENERGY DRINKS MARKET - GROWTH, TRENDS, COVID-19 IMPACT, AND FORECASTS (2021 - 2026). 2021; https://www.mordorintelligence.com/industry-reports/africa-energy-drink-market.
2. Alsunni AA. Energy Drink Consumption: Beneficial and Adverse Health Effects. International journal of health sciences. Oct 2015;9(4):468-474.
3. Top 50 most popular Energy drinks. 2021; https://www.nutritionix.com/grocery/category/soda/energy-drink/244. Accessed 12/12/2021, 2021.
4. Bizvibe. https://blog.bizvibe.com/blog/largest-energy-drink-brands. In: Bizvibe, ed. Vol 20212021.
5. Foster J. Top Selling Energy Drink Brands. 2021; https://www.caffeineinformer.com/the-15-top-energy-drink-brands. Accessed 12/12/2021, 2021.
6. Miller C, Ettridge K, Wakefield M, et al. Consumption of Sugar-Sweetened Beverages, Juice, Artificially-Sweetened Soda and Bottled Water: An Australian Population Study. Nutrients. Mar 19 2020;12(3).
7. Sorkin BC, Camp KM, Haggans CJ, et al. Executive summary of NIH workshop on the Use and Biology of Energy Drinks: Current Knowledge and Critical Gaps. Nutrition reviews. Oct 2014;72 Suppl 1:1-8.
8. Adams J, Hofman K, Moubarac JC, Thow AM. Public health response to ultra-processed food and drinks. BMJ. Jun 26 2020;369:m2391.
9. Bonfiglioli C, Hattersley L, King L. Australian print news media coverage of sweet, non-alcoholic drinks sends mixed health messages. Aust N Z J Public Health. Aug 2011;35(4):325-330.
10. Collins B, Capewell S, O'Flaherty M, et al. Modelling the Health Impact of an English Sugary Drinks Duty at National and Local Levels. PloS one. 2015;10(6):e0130770.
11. Datta BK, Husain MJ. Carbonating the household diet: a Pakistani tale. Public health nutrition. Jun 2020;23(9):1629-1637.
12. Fidler Mis N, Braegger C, Bronsky J, et al. Sugar in Infants, Children and Adolescents: A Position Paper of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition. J Pediatr Gastroenterol Nutr. Dec 2017;65(6):681-696.
13. Gupta P, Shah D, Kumar P, et al. Indian Academy of Pediatrics Guidelines on the Fast and Junk Foods, Sugar Sweetened Beverages, Fruit Juices, and Energy Drinks. Indian pediatrics. Oct 15 2019;56(10):849-863.
14. Gutierrez-Hellin J, Varillas-Delgado D. Energy Drinks and Sports Performance, Cardiovascular Risk, and Genetic Associations; Future Prospects. Nutrients. Feb 24 2021;13(3).
15. Lasater G, Piernas C, Popkin BM. Beverage patterns and trends among school-aged children in the US, 1989-2008. Nutrition journal. Oct 2 2011;10:103.
16. Mackus M, van de Loo A, Benson S, Scholey A, Verster JC. Consumption of caffeinated beverages and the awareness of their caffeine content among Dutch students. Appetite. Aug 1 2016;103:353-357.
17. Seifert SM, Schaechter JL, Hershorin ER, Lipshultz SE. Health effects of energy drinks on children, adolescents, and young adults. Pediatrics. Mar 2011;127(3):511-528.
18. Pabayo R, Spence JC, Casey L, Storey K. Food consumption patterns in preschool children. Canadian journal of dietetic practice and research : a publication of Dietitians of Canada = Revue canadienne de la pratique et de la recherche en dietetique : une publication des Dietetistes du Canada. Summer 2012;73(2):66-71.
19. Pabayo R, Spence JC, Cutumisu N, Casey L, Storey K. Sociodemographic, behavioural and environmental correlates of sweetened beverage consumption among pre-school children. Public health nutrition. Aug 2012;15(8):1338-1346.
20. Higgins JP, Tuttle TD, Higgins CL. Energy beverages: content and safety. Mayo Clinic proceedings. Nov 2010;85(11):1033-1041.
21. Higgins PB, Bastarrachea RA, Lopez-Alvarenga JC, et al. Eight week exposure to a high sugar high fat diet results in adiposity gain and alterations in metabolic biomarkers in baboons (Papio hamadryas sp.). Cardiovascular diabetology. Oct 29 2010;9:71.
22. Mansour B, Amarah W, Nasralla E, Elias N. Energy drinks in children and adolescents: demographic data and immediate effects. Eur J Pediatr. May 2019;178(5):649-656.
23. Bell RA, Mayer-Davis EJ, Martin MA, D'Agostino RB, Jr., Haffner SM. Associations between alcohol consumption and insulin sensitivity and cardiovascular disease risk factors: the Insulin Resistance and Atherosclerosis Study. Diabetes care. Nov 2000;23(11):1630-1636.
24. Di Minno MN, Franchini M, Russolillo A, Lupoli R, Iervolino S, Di Minno G. Alcohol dosing and the heart: updating clinical evidence. Semin Thromb Hemost. Nov 2011;37(8):875-884.
25. Djousse L, Arnett DK, Eckfeldt JH, Province MA, Singer MR, Ellison RC. Alcohol consumption and metabolic syndrome: does the type of beverage matter? Obes Res. Sep 2004;12(9):1375-1385.
26. Hu EA, Lazo M, Rosenberg SD, et al. Alcohol Consumption and Incident Kidney Disease: Results From the Atherosclerosis Risk in Communities Study. J Ren Nutr. Jan 2020;30(1):22-30.
27. Martz ME, Patrick ME, Schulenberg JE. Alcohol mixed with energy drink use among u.s. 12th-grade students: prevalence, correlates, and associations with unsafe driving. The Journal of adolescent health : official publication of the Society for Adolescent Medicine. May 2015;56(5):557-563.
28. Powers G, Berger L. Alcohol mixed with energy drinks: Expectancies of use and alcohol-related negative consequences among a young adult sample. Addictive behaviors reports. Dec 2020;12:100292.
29. Tucker JS, Troxel WM, Ewing BA, D'Amico EJ. Alcohol mixed with energy drinks: Associations with risky drinking and functioning in high school. Drug and alcohol dependence. Oct 1 2016;167:36-41.
30. Verster JC, Benson S, Johnson SJ, Scholey A, Alford C. Mixing alcohol with energy drink (AMED) and total alcohol consumption: a systematic review and meta-analysis. Human psychopharmacology. Jan 2016;31(1):2-10.
31. Hayes SL, Mann MK, Morgan FM, Kelly MJ, Weightman AL. Collaboration between local health and local government agencies for health improvement. The Cochrane database of systematic reviews. Oct 17 2012;10:CD007825.
32. Marczinski CA. Can energy drinks increase the desire for more alcohol? Advances in nutrition. Jan 2015;6(1):96-101.
33. Marczinski CA, Fillmore MT. Energy drinks mixed with alcohol: what are the risks? Nutrition reviews. Oct 2014;72 Suppl 1:98-107.
34. Marczinski CA, Stamates AL, Ossege J, Maloney SF, Bardgett ME, Brown CJ. Subjective State, Blood Pressure, and Behavioral Control Changes Produced by an "Energy Shot". Journal of caffeine research. Jun 1 2014;4(2):57-63.
35. Takechi R, Mamo J, Das S, et al. Short-term consumption of alcohol (vodka) mixed with energy drink (AMED) attenuated alcohol-induced cerebral capillary disturbances and neuroinflammation in adult wild-type mice. Nutritional neuroscience. Sep 22 2021:1-10.
36. Marczinski CA. Alcohol mixed with energy drinks: consumption patterns and motivations for use in U.S. college students. International journal of environmental research and public health. Aug 2011;8(8):3232-3245.
37. Marczinski CA, Fillmore MT, Bardgett ME, Howard MA. Effects of energy drinks mixed with alcohol on behavioral control: risks for college students consuming trendy cocktails. Alcoholism, clinical and experimental research. Jul 2011;35(7):1282-1292.
38. Marczinski CA, Fillmore MT, Henges AL, Ramsey MA, Young CR. Effects of energy drinks mixed with alcohol on information processing, motor coordination and subjective reports of intoxication. Experimental and clinical psychopharmacology. Apr 2012;20(2):129-138.
39. O'Brien MC, McCoy TP, Rhodes SD, Wagoner A, Wolfson M. Caffeinated cocktails: energy drink consumption, high-risk drinking, and alcohol-related consequences among college students. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. May 2008;15(5):453-460.
40. de Haan L, de Haan HA, van der Palen J, Olivier B, Verster JC. Effects of consuming alcohol mixed with energy drinks versus consuming alcohol only on overall alcohol consumption and negative alcohol-related consequences. International journal of general medicine. 2012;5:953-960.
41. Berger LK, Fendrich M, Chen HY, Arria AM, Cisler RA. Sociodemographic correlates of energy drink consumption with and without alcohol: results of a community survey. Addictive behaviors. May 2011;36(5):516-519.
42. Khan MR, Berger AT, Wells BE, Cleland CM. Longitudinal associations between adolescent alcohol use and adulthood sexual risk behavior and sexually transmitted infection in the United States: assessment of differences by race. American journal of public health. May 2012;102(5):867-876.
43. Arria AM, Caldeira KM, Kasperski SJ, et al. Increased alcohol consumption, nonmedical prescription drug use, and illicit drug use are associated with energy drink consumption among college students. Journal of addiction medicine. Jun 2010;4(2):74-80.
44. Arria AM, Caldeira KM, Kasperski SJ, Vincent KB, Griffiths RR, O'Grady KE. Energy drink consumption and increased risk for alcohol dependence. Alcoholism, clinical and experimental research. Feb 2011;35(2):365-375.
45. Attila S, Cakir B. Energy-drink consumption in college students and associated factors. Nutrition. Mar 2011;27(3):316-322.
46. Brache K, Stockwell T. Drinking patterns and risk behaviors associated with combined alcohol and energy drink consumption in college drinkers. Addictive behaviors. Dec 2011;36(12):1133-1140.
47. Cheng WJ, Cheng Y, Huang MC, Chen CJ. Alcohol dependence, consumption of alcoholic energy drinks and associated work characteristics in the Taiwan working population. Alcohol and alcoholism. Jul-Aug 2012;47(4):372-379.
48. Eckschmidt F, de Andrade AG, dos Santos B, de Oliveira LG. The effects of alcohol mixed with energy drinks (AmED) on traffic behaviors among Brazilian college students: a national survey. Traffic injury prevention. 2013;14(7):671-679.
49. Price SR, Hilchey CA, Darredeau C, Fulton HG, Barrett SP. Energy drink co-administration is associated with increased reported alcohol ingestion. Drug and alcohol review. May 2010;29(3):331-333.
50. Snipes DJ, Benotsch EG. High-risk cocktails and high-risk sex: examining the relation between alcohol mixed with energy drink consumption, sexual behavior, and drug use in college students. Addictive behaviors. Jan 2013;38(1):1418-1423.
51. Snipes DJ, Green BA, Javier SJ, Perrin PB, Benotsch EG. The use of alcohol mixed with energy drinks and experiences of sexual victimization among male and female college students. Addictive behaviors. Jan 2014;39(1):259-264.
52. Berger L, Fendrich M, Fuhrmann D. Alcohol mixed with energy drinks: are there associated negative consequences beyond hazardous drinking in college students? Addictive behaviors. Sep 2013;38(9):2428-2432.
53. Jacobson BH, Hughes PP, Conchola EC, Hester GM, Woolsey CL. Effect of Energy Drinks on Selected Fine Motor Tasks. Perceptual and motor skills. Aug 2015;121(1):170-178.
54. Miller KE. Alcohol Mixed with Energy Drink Use and Sexual Risk-Taking: Casual, Intoxicated, and Unprotected Sex. Journal of caffeine research. Jun 2012;2(2):62-69.
55. Sather TE, Woolsey CL, Williams RD, Jr., Evans MW, Jr., Cromartie F. Age of first use of energy beverages predicts future maximal consumption among naval pilot and flight officer candidates. Addictive behaviors reports. Jun 2016;3:9-13.
56. Woolsey CL, Jacobson BH, Williams RD, Jr., et al. A comparison of the combined-use of alcohol & energy drinks to alcohol-only on high-risk drinking and driving behaviors. Substance use & misuse. Jan 2015;50(1):1-7.
57. Woolsey CL, Williams RD, Jr., Housman JM, Barry AE, Jacobson BH, Evans MW, Jr. Combined Use of Alcohol and Energy Drinks Increases Participation in High-Risk Drinking and Driving Behaviors Among College Students. Journal of studies on alcohol and drugs. Jul 2015;76(4):615-619.
58. Woolsey CL, Williams RD, Jr., Jacobson BH, et al. Increased Energy Drink Use as a Predictor of Illicit Prescription Stimulant Use. Substance abuse. 2015;36(4):413-419.
59. de Haan L, Egberts AC, Heerdink ER. The relation between risk-taking behavior and alcohol use in young adults is different for men and women. Drug and alcohol dependence. Oct 1 2015;155:222-227.
60. Writing Group M, Mozaffarian D, Benjamin EJ, et al. Executive Summary: Heart Disease and Stroke Statistics--2016 Update: A Report From the American Heart Association. Circulation. Jan 26 2016;133(4):447-454.
61. Writing Group M, Mozaffarian D, Benjamin EJ, et al. Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association. Circulation. Jan 26 2016;133(4):e38-360.
62. Olateju T, Begley J, Green DJ, Kerr D. Physiological and glycemic responses following acute ingestion of a popular functional drink in patients with type 1 diabetes. Can J Diabetes. Feb 2015;39(1):78-82.
63. Trapp G, Hurworth M, Jacoby P, et al. Energy drink intake and metabolic syndrome: A prospective investigation in young adults. Nutr Metab Cardiovasc Dis. Sep 24 2020;30(10):1679-1684.
64. England CY, Andrews R, Jago R, Thompson JL. Changes in reported food intake in adults with type 2 diabetes in response to a nonprescriptive dietary intervention. Journal of human nutrition and dietetics : the official journal of the British Dietetic Association. Aug 2014;27(4):311-321.
65. Evans CEL. Sugars and health: a review of current evidence and future policy. Proc Nutr Soc. Aug 2017;76(3):400-407.
66. Yong HY, Mohd Shariff Z, Mohd Yusof BN, et al. Beverage Intake and the Risk of Gestational Diabetes Mellitus: The SECOST. Nutrients. Jun 27 2021;13(7).
67. Yu R, Woo J, Chan R, et al. Relationship between dietary intake and the development of type 2 diabetes in a Chinese population: the Hong Kong Dietary Survey. Public health nutrition. Jul 2011;14(7):1133-1141.
68. Zaparolli MR, MRR DA-C, Frehner C, et al. Food Intake Evaluation during the First Year of Postoperative of Patients with Type 2 Diabetes Mellitus or Glycemic Alteration Submitted to Roux-En-Y Gastric Bypass. Arq Bras Cir Dig. 2018;31(2):e1367.
69. (NIDDK) NIoDaDaKD. Diabetes Statistics. 2021; https://www.niddk.nih.gov/health-information/health-statistics/diabetes-statistics.
70. prevention. USDoHaHSCfDca. National Diabetes Statistics Report 2020; Estimates of Diabetes and Its Burden in the United States. 2020; https://www.cdc.gov/diabetes/pdfs/data/statistics/national-diabetes-statistics-report.pdf.
71. Shah NS, Wang MC, Freaney PM, et al. Trends in Gestational Diabetes at First Live Birth by Race and Ethnicity in the US, 2011-2019. Jama. Aug 17 2021;326(7):660-669.
72. Wang J, Luben R, Khaw KT, Bingham S, Wareham NJ, Forouhi NG. Dietary energy density predicts the risk of incident type 2 diabetes: the European Prospective Investigation of Cancer (EPIC)-Norfolk Study. Diabetes care. Nov 2008;31(11):2120-2125.
73. Wang L, Li X, Wang Z, et al. Trends in Prevalence of Diabetes and Control of Risk Factors in Diabetes Among US Adults, 1999-2018. Jama. Jun 25 2021.
74. Saran R, Li Y, Robinson B, et al. US Renal Data System 2014 Annual Data Report: Epidemiology of Kidney Disease in the United States. American journal of kidney diseases : the official journal of the National Kidney Foundation. Jul 2015;66(1 Suppl 1):Svii, S1-305.
75. Burt VL, Cutler JA, Higgins M, et al. Trends in the prevalence, awareness, treatment, and control of hypertension in the adult US population. Data from the health examination surveys, 1960 to 1991. Hypertension. Jul 1995;26(1):60-69.
76. Burt VL, Whelton P, Roccella EJ, et al. Prevalence of hypertension in the US adult population. Results from the Third National Health and Nutrition Examination Survey, 1988-1991. Hypertension. Mar 1995;25(3):305-313.
77. Egan BM. The prevalence and control of hypertension in adults. 2021; https://www.uptodate.com/contents/the-prevalence-and-control-of-hypertension-in-adults.
78. Ostchega Y, Fryar CD, Nwankwo T, Nguyen DT. Hypertension Prevalence Among Adults Aged 18 and Over: United States, 2017-2018. NCHS data brief. Apr 2020(364):1-8.
79. Prevention. CfDCa. High blood pressure; Facts about hypertension. 2021; https://www.cdc.gov/bloodpressure/facts.htm.
80. Audain K, Levy L, Ellahi B. Sugar-sweetened beverage consumption in the early years and implications for type-2 diabetes: a sub-Saharan Africa context. Proc Nutr Soc. Nov 2019;78(4):547-553.
81. Ballard SL, Wellborn-Kim JJ, Clauson KA. Effects of commercial energy drink consumption on athletic performance and body composition. The Physician and sportsmedicine. Apr 2010;38(1):107-117.
82. Basrai M, Schweinlin A, Menzel J, et al. Energy Drinks Induce Acute Cardiovascular and Metabolic Changes Pointing to Potential Risks for Young Adults: A Randomized Controlled Trial. The Journal of nutrition. Mar 1 2019;149(3):441-450.
83. Berg CM, Lappas G, Strandhagen E, et al. Food patterns and cardiovascular disease risk factors: the Swedish INTERGENE research program. The American journal of clinical nutrition. Aug 2008;88(2):289-297.
84. Chrysant SG, Chrysant GS. Cardiovascular complications from consumption of high energy drinks: recent evidence. J Hum Hypertens. Feb 2015;29(2):71-76.
85. de Koning L, Malik VS, Rimm EB, Willett WC, Hu FB. Sugar-sweetened and artificially sweetened beverage consumption and risk of type 2 diabetes in men. The American journal of clinical nutrition. Jun 2011;93(6):1321-1327.
86. Dhingra R, Sullivan L, Jacques PF, et al. Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community. Circulation. Jul 31 2007;116(5):480-488.
87. Dominguez LJ, Martinez-Gonzalez MA, Basterra-Gortari FJ, Gea A, Barbagallo M, Bes-Rastrollo M. Fast food consumption and gestational diabetes incidence in the SUN project. PloS one. 2014;9(9):e106627.
88. Donazar-Ezcurra M, Lopez-Del Burgo C, Martinez-Gonzalez MA, Basterra-Gortari FJ, de Irala J, Bes-Rastrollo M. Soft drink consumption and gestational diabetes risk in the SUN project. Clinical nutrition. Apr 2018;37(2):638-645.
89. Duchan E, Patel ND, Feucht C. Energy drinks: a review of use and safety for athletes. The Physician and sportsmedicine. Jun 2010;38(2):171-179.
90. Fisk G, Hammond-Haley M, D'Silva A. Energy drink-induced cardiomyopathy. BMJ Case Rep. Apr 15 2021;14(4).
91. Gharacholou SM, Ijioma N, Banwart E, Munoz FD. ST-Segment Elevation Myocardial Infarction and Normal Coronary Arteries after Consuming Energy Drinks. Case Rep Cardiol. 2017;2017:4061205.
92. Graneri LT, Mamo JCL, D'Alonzo Z, Lam V, Takechi R. Chronic Intake of Energy Drinks and Their Sugar Free Substitution Similarly Promotes Metabolic Syndrome. Nutrients. Apr 6 2021;13(4).
93. Hu FB, Malik VS. Sugar-sweetened beverages and risk of obesity and type 2 diabetes: epidemiologic evidence. Physiology & behavior. Apr 26 2010;100(1):47-54.
94. Kaminer Y. Problematic use of energy drinks by adolescents. Child and adolescent psychiatric clinics of North America. Jul 2010;19(3):643-650.
95. Malik VS, Popkin BM, Bray GA, Despres JP, Willett WC, Hu FB. Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis. Diabetes care. Nov 2010;33(11):2477-2483.
96. Nguyen S, Choi HK, Lustig RH, Hsu CY. Sugar-sweetened beverages, serum uric acid, and blood pressure in adolescents. J Pediatr. Jun 2009;154(6):807-813.
97. Niemczyk M, Stopa M, Lobacz M, Rutkowska K, Radko A. Influence of energy drinks on hemodynamic parameters in young healthy adults - Randomized double-blind placebo controlled cross-over study: PS020. Porto Biomed J. Sep-Oct 2017;2(5):199.
98. Paglia L. The sweet danger of added sugars. Eur J Paediatr Dent. Jun 2019;20(2):89.
99. Pase MP, Himali JJ, Beiser AS, et al. Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia: A Prospective Cohort Study. Stroke. May 2017;48(5):1139-1146.
100. Robin S, Buchanan R, Poole R. Energy drinks and adolescents - A hepatic health hazard? J Hepatol. Apr 2018;68(4):856-857.
101. Roeb E, Weiskirchen R. Fructose and Non-Alcoholic Steatohepatitis. Front Pharmacol. 2021;12:634344.
102. Shah SA, Chu BW, Lacey CS, Riddock IC, Lee M, Dargush AE. Impact of Acute Energy Drink Consumption on Blood Pressure Parameters: A Meta-analysis. Ann Pharmacother. Oct 2016;50(10):808-815.
103. Shin S, Kim SA, Ha J, Lim K. Sugar-Sweetened Beverage Consumption in Relation to Obesity and Metabolic Syndrome among Korean Adults: A Cross-Sectional Study from the 2012(-)2016 Korean National Health and Nutrition Examination Survey (KNHANES). Nutrients. Oct 9 2018;10(10).
104. Shoham DA, Durazo-Arvizu R, Kramer H, et al. Sugary soda consumption and albuminuria: results from the National Health and Nutrition Examination Survey, 1999-2004. PloS one. 2008;3(10):e3431.
105. Voskoboinik A, Koh Y, Kistler PM. Cardiovascular effects of caffeinated beverages. Trends Cardiovasc Med. Aug 2019;29(6):345-350.
106. Wikoff D, Welsh BT, Henderson R, et al. Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. Nov 2017;109(Pt 1):585-648.
107. Butt MS, Sultan MT. Coffee and its consumption: benefits and risks. Critical reviews in food science and nutrition. Apr 2011;51(4):363-373.
108. van Dam RM. Coffee consumption and risk of type 2 diabetes, cardiovascular diseases, and cancer. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. Dec 2008;33(6):1269-1283.
109. Cornelis MC, El-Sohemy A, Campos H. Genetic polymorphism of the adenosine A2A receptor is associated with habitual caffeine consumption. The American journal of clinical nutrition. Jul 2007;86(1):240-244.
110. Laitala VS, Kaprio J, Silventoinen K. Genetics of coffee consumption and its stability. Addiction. Dec 2008;103(12):2054-2061.
111. Yang A, Palmer AA, de Wit H. Genetics of caffeine consumption and responses to caffeine. Psychopharmacology. Aug 2010;211(3):245-257.
112. Drucker DJ. Incretin action in the pancreas: potential promise, possible perils, and pathological pitfalls. Diabetes. Oct 2013;62(10):3316-3323.
113. Hussein GM, Matsuda H, Nakamura S, et al. Mate tea (Ilex paraguariensis) promotes satiety and body weight lowering in mice: involvement of glucagon-like peptide-1. Biological & pharmaceutical bulletin. 2011;34(12):1849-1855.
114. Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Microbial ecology: human gut microbes associated with obesity. Nature. Dec 21 2006;444(7122):1022-1023.
115. Cowan TE, Palmnas MS, Yang J, et al. Chronic coffee consumption in the diet-induced obese rat: impact on gut microbiota and serum metabolomics. The Journal of nutritional biochemistry. Apr 2014;25(4):489-495.
116. Greenblum S, Turnbaugh PJ, Borenstein E. Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease. Proceedings of the National Academy of Sciences of the United States of America. Jan 10 2012;109(2):594-599.
117. Payne AN, Chassard C, Lacroix C. Gut microbial adaptation to dietary consumption of fructose, artificial sweeteners and sugar alcohols: implications for host-microbe interactions contributing to obesity. Obesity reviews : an official journal of the International Association for the Study of Obesity. Sep 2012;13(9):799-809.
118. Administration USFaD. Spilling the Beans: How Much Caffeine is Too Much? 2021; https://www.fda.gov/consumers/consumer-updates/spilling-beans-how-much-caffeine-too-much. Accessed 12/12/2021, 2021.
119. Heckman MA, Weil J, Gonzalez de Mejia E. Caffeine (1, 3, 7-trimethylxanthine) in foods: a comprehensive review on consumption, functionality, safety, and regulatory matters. Journal of food science. Apr 2010;75(3):R77-87.
120. Troxel WM, Tucker JS, Ewing B, Miles JNV, D'Amico EJ. Sleepy Teens and Energy Drink Use: Results From an Ethnically Diverse Sample of Youth. Behavioral sleep medicine. May-Jun 2018;16(3):223-234.
121. Willson C. The clinical toxicology of caffeine: A review and case study. Toxicology reports. 2018;5:1140-1152.
122. Cappelletti S, Piacentino D, Fineschi V, Frati P, Cipolloni L, Aromatario M. Caffeine-Related Deaths: Manner of Deaths and Categories at Risk. Nutrients. May 14 2018;10(5).
123. Osswald H, Schnermann J. Methylxanthines and the kidney. Handbook of experimental pharmacology. 2011(200):391-412.
124. Willson C. Sympathomimetic amine compounds and hepatotoxicity: Not all are alike-Key distinctions noted in a short review. Toxicology reports. 2019;6:26-33.
125. Sorkin BC, Coates PM. Caffeine-containing energy drinks: beginning to address the gaps in what we know. Advances in nutrition. Sep 2014;5(5):541-543.
126. Trabulo D, Marques S, Pedroso E. Caffeinated energy drink intoxication. BMJ Case Rep. Feb 2 2011;2011.
127. Choudhury TR, Abdool MA, Galasko G. Energy drinks give you wings but also an abnormal exercise test. BMJ Case Rep. Jul 27 2017;2017.
128. Mahmud A, Feely J. Acute effect of caffeine on arterial stiffness and aortic pressure waveform. Hypertension. Aug 2001;38(2):227-231.
129. Bkaily G, Jazzar A, Normand A, Simon Y, Al-Khoury J, Jacques D. Taurine and cardiac disease: state of the art and perspectives. Can J Physiol Pharmacol. Feb 2020;98(2):67-73.
130. Wojcik OP, Koenig KL, Zeleniuch-Jacquotte A, Costa M, Chen Y. The potential protective effects of taurine on coronary heart disease. Atherosclerosis. Jan 2010;208(1):19-25.
131. Seidl R, Peyrl A, Nicham R, Hauser E. A taurine and caffeine-containing drink stimulates cognitive performance and well-being. Amino acids. 2000;19(3-4):635-642.
132. Boasquivis PF, Silva GMM, Paiva FA, Cavalcanti RM, Nunez CV, de Paula Oliveira R. Guarana (Paullinia cupana) Extract Protects Caenorhabditis elegans Models for Alzheimer Disease and Huntington Disease through Activation of Antioxidant and Protein Degradation Pathways. Oxidative medicine and cellular longevity. 2018;2018:9241308.
133. Peixoto H, Roxo M, Rohrig T, Richling E, Wang X, Wink M. Anti-Aging and Antioxidant Potential of Paullinia cupana var. sorbilis: Findings in Caenorhabditis elegans Indicate a New Utilization for Roasted Seeds of Guarana. Medicines. Aug 15 2017;4(3).
134. Schimpl FC, da Silva JF, Goncalves JF, Mazzafera P. Guarana: revisiting a highly caffeinated plant from the Amazon. Journal of ethnopharmacology. Oct 28 2013;150(1):14-31.
135. Zeidan-Chulia F, Gelain DP, Kolling EA, et al. Major components of energy drinks (caffeine, taurine, and guarana) exert cytotoxic effects on human neuronal SH-SY5Y cells by decreasing reactive oxygen species production. Oxidative medicine and cellular longevity. 2013;2013:791795.
136. Woods DJ. Guarana: Paullinia cupana, P. sorbilis; also known as Brazilian cocoa and 'zoom'. Journal of primary health care. Jun 1 2012;4(2):163-164.
137. Smith N, Atroch AL. Guarana's Journey from Regional Tonic to Aphrodisiac and Global Energy Drink. Evidence-based complementary and alternative medicine : eCAM. Sep 2010;7(3):279-282.
138. Moustakas D, Mezzio M, Rodriguez BR, Constable MA, Mulligan ME, Voura EB. Guarana provides additional stimulation over caffeine alone in the planarian model. PloS one. 2015;10(4):e0123310.
139. Boyina R, Dodoala S. Evaluation of the Neurobehavioural Toxic Effects of Taurine, Glucuronolactone, and Gluconolactone Used in Energy Drinks in Young Rats. Turkish journal of pharmaceutical sciences. Dec 23 2020;17(6):659-666.
140. McLellan TM, Lieberman HR. Do energy drinks contain active components other than caffeine? Nutrition reviews. Dec 2012;70(12):730-744.
141. Miles-Chan JL, Charriere N, Grasser EK, Montani JP, Dulloo AG. The thermic effect of sugar-free Red Bull: do the non-caffeine bioactive ingredients in energy drinks play a role? Obesity. Jan 2015;23(1):16-19.
142. Ricciutelli M, Caprioli G, Cortese M, et al. Simultaneous determination of taurine, glucuronolactone and glucuronic acid in energy drinks by ultra high performance liquid chromatography-tandem mass spectrometry (triple quadrupole). Journal of chromatography. A. Oct 17 2014;1364:303-307.
143. Abenavoli L, Capasso R, Milic N, Capasso F. Milk thistle in liver diseases: past, present, future. Phytotherapy research : PTR. Oct 2010;24(10):1423-1432.
144. Albassam AA, Frye RF, Markowitz JS. The effect of milk thistle (Silybum marianum) and its main flavonolignans on CYP2C8 enzyme activity in human liver microsomes. Chemico-biological interactions. Jun 1 2017;271:24-29.
145. Bray GA. Fructose: pure, white, and deadly? Fructose, by any other name, is a health hazard. J Diabetes Sci Technol. Jul 1 2010;4(4):1003-1007.
146. Bray GA. Energy and fructose from beverages sweetened with sugar or high-fructose corn syrup pose a health risk for some people. Advances in nutrition. Mar 1 2013;4(2):220-225.
147. Bray GA, Popkin BM. Dietary sugar and body weight: have we reached a crisis in the epidemic of obesity and diabetes?: health be damned! Pour on the sugar. Diabetes care. Apr 2014;37(4):950-956.
148. Vos MB, Lavine JE. Dietary fructose in nonalcoholic fatty liver disease. Hepatology. Jun 2013;57(6):2525-2531.
149. Bray GA. Fructose: should we worry? International journal of obesity. Dec 2008;32 Suppl 7:S127-131.
150. DeChristopher LR, Tucker KL. Excess free fructose, high-fructose corn syrup and adult asthma: the Framingham Offspring Cohort. The British journal of nutrition. May 2018;119(10):1157-1167.
151. DeChristopher LR, Uribarri J, Tucker KL. Intake of high fructose corn syrup sweetened soft drinks, fruit drinks and apple juice is associated with prevalent coronary heart disease, in U.S. adults, ages 45-59 y. BMC Nutr. 2017;3:51.
152. Ferder L, Ferder MD, Inserra F. The role of high-fructose corn syrup in metabolic syndrome and hypertension. Curr Hypertens Rep. Apr 2010;12(2):105-112.
153. Saeed SA, Hameed A, Yousif S, Lessan N. The perils of high carbohydrate drinks in the undiagnosed diabetic patient. BMJ Case Rep. Aug 11 2011;2011.
154. Stricker S, Rudloff S, Geier A, Steveling A, Roeb E, Zimmer KP. Fructose Consumption-Free Sugars and Their Health Effects. Dtsch Arztebl Int. Feb 5 2021;118(5):71-78.
155. Taskinen MR, Packard CJ, Boren J. Dietary Fructose and the Metabolic Syndrome. Nutrients. Aug 22 2019;11(9).
156. den Biggelaar L, Sep SJS, Mari A, et al. Association of artificially sweetened and sugar-sweetened soft drinks with beta-cell function, insulin sensitivity, and type 2 diabetes: the Maastricht Study. European journal of nutrition. Jun 2020;59(4):1717-1727.
157. Omran A, Ahearn G, Bowers D, Swenson J, Coughlin C. Metabolic effects of sucralose on environmental bacteria. Journal of toxicology. 2013;2013:372986.
158. Omran A, Baker R, Coughlin C. Differential bacteriostatic effects of sucralose on various species of environmental bacteria. ISRN toxicology. 2013;2013:415070.
159. AlDeeb OA, Mahgoub H, Foda NH. Sucralose. Profiles of drug substances, excipients, and related methodology. 2013;38:423-462.
160. Carlomagno G, Unfer V. Inositol safety: clinical evidences. European review for medical and pharmacological sciences. Aug 2011;15(8):931-936.
161. Hofman DL, van Buul VJ, Brouns FJ. Nutrition, Health, and Regulatory Aspects of Digestible Maltodextrins. Critical reviews in food science and nutrition. Sep 9 2016;56(12):2091-2100.
162. Shishtar E, Jovanovski E, Jenkins A, Vuksan V. Effects of Korean White Ginseng (Panax Ginseng C.A. Meyer) on Vascular and Glycemic Health in Type 2 Diabetes: Results of a Randomized, Double Blind, Placebo-controlled, Multiple-crossover, Acute Dose Escalation Trial. Clinical nutrition research. Jul 2014;3(2):89-97.
163. Shishtar E, Sievenpiper JL, Djedovic V, et al. The effect of ginseng (the genus panax) on glycemic control: a systematic review and meta-analysis of randomized controlled clinical trials. PloS one. 2014;9(9):e107391.
164. Diamond BJ, Bailey MR. Ginkgo biloba: indications, mechanisms, and safety. The Psychiatric clinics of North America. Mar 2013;36(1):73-83.
165. Shannon CE, Nixon AV, Greenhaff PL, Stephens FB. Protein ingestion acutely inhibits insulin-stimulated muscle carnitine uptake in healthy young men. The American journal of clinical nutrition. Jan 2016;103(1):276-282.
166. Heckman MA, Sherry K, De Mejia EG. Energy Drinks: An Assessment of Their Market Size, Consumer Demographics, Ingredient Profile, Functionality, and Regulations in the United States. Comprehensive reviews in food science and food safety. May 2010;9(3):303-317.
167. Staff MC. Nutrition and Healthy Eating; Artificial sweetners and other sugar substitutes. 2020; https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/in-depth/artificial-sweeteners/art-20046936.
168. Wikipedia. Sugar Substitute. 2021; https://en.wikipedia.org/wiki/Sugar_substitute.
169. Salomon SH, Kennedy K. The 9 Best Sugar Substitutes for People With Type 2 Diabetes. 2019; https://www.everydayhealth.com/type-2-diabetes/diet/sugar-substitutes-for-diabetes/.
170. FDA US. How Sweet It Is: All About Sugar Substitutes. 2020; https://www.fda.gov/consumers/consumer-updates/how-sweet-it-all-about-sugar-substitutes.
171. Wax E, Zieve D, Conaway B, team ADAME. Sweeteners - sugar substitutes. 2019; https://medlineplus.gov/ency/article/007492.htm.
172. Graneri L, Lam V, D'Alonzo Z, Nesbit M, Mamo JCL, Takechi R. The Consumption of Energy Drinks Induces Blood-Brain Barrier Dysfunction in Wild-Type Mice. Frontiers in nutrition. 2021;8:668514.
173. Ruiz-Ojeda FJ, Plaza-Diaz J, Saez-Lara MJ, Gil A. Effects of Sweeteners on the Gut Microbiota: A Review of Experimental Studies and Clinical Trials. Advances in nutrition. Jan 1 2019;10(suppl_1):S31-S48.
174. Sandolu A, Robertson C. Coffee drinkers have healthier gut microbiotas. 2019; https://www.medicalnewstoday.com/articles/326845.
175. Alford C, Hamilton-Morris J, Verster JC. The effects of energy drink in combination with alcohol on performance and subjective awareness. Psychopharmacology. Aug 2012;222(3):519-532.
176. de Haan L, de Haan HA, Olivier B, Verster JC. Alcohol mixed with energy drinks: methodology and design of the Utrecht Student Survey. International journal of general medicine. 2012;5:889-898.
177. Verster JC, Alford C, Scholey A. The alcohol mixed with energy drink debate: masking the facts! A commentary on "Mixing an energy drink with an alcoholic beverage increases motivation for more alcohol in college students" by Marczinski and colleagues (in press). Alcoholism, clinical and experimental research. Apr 2013;37(4):703-705.
178. Verster JC, Aufricht C, Alford C. Energy drinks mixed with alcohol: misconceptions, myths, and facts. International journal of general medicine. 2012;5:187-198.
179. Howard AL, Patrick ME, Maggs JL. College student affect and heavy drinking: Variable associations across days, semesters, and people. Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors. Jun 2015;29(2):430-443.
180. Patrick ME, Evans-Polce RJ, Maggs JL. Use of alcohol mixed with energy drinks as a predictor of alcohol-related consequences two years later. Journal of studies on alcohol and drugs. Sep 2014;75(5):753-757.
181. Patrick ME, Maggs JL. Energy drinks and alcohol: links to alcohol behaviors and consequences across 56 days. The Journal of adolescent health : official publication of the Society for Adolescent Medicine. Apr 2014;54(4):454-459.
182. Dillon P, Kelpin S, Kendler K, Thacker L, Dick D, Svikis D. Gender Differences in Any-Source Caffeine and Energy Drink Use and Associated Adverse Health Behaviors. Journal of caffeine and adenosine research. Mar 1 2019;9(1):12-19.
183. Arnaud MJ. Pharmacokinetics and metabolism of natural methylxanthines in animal and man. Handbook of experimental pharmacology. 2011(200):33-91.
184. Brunner Y, Schvartz D, Priego-Capote F, Coute Y, Sanchez JC. Glucotoxicity and pancreatic proteomics. Journal of proteomics. Jan 30 2009;71(6):576-591.
185. Luo X, Wu J, Jing S, Yan LJ. Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity. Aging and disease. Jan 2016;7(1):90-110.
186. Mooradian AD, Thurman JE. Glucotoxicity: potential mechanisms. Clinics in geriatric medicine. May 1999;15(2):255.
187. Grasser EK, Miles-Chan JL, Charriere N, Loonam CR, Dulloo AG, Montani JP. Energy Drinks and Their Impact on the Cardiovascular System: Potential Mechanisms. Advances in nutrition. Sep 2016;7(5):950-960.
188. Iyer PS, Yelisetti R, Miriyala V, Siddiqui W, Kaji A. A remarkable case of rhabdomyolysis associated with ingestion of energy drink 'neon volt'. J Community Hosp Intern Med Perspect. 2016;6(5):32528.
189. Johnson RK, Appel LJ, Brands M, et al. Dietary sugars intake and cardiovascular health: a scientific statement from the American Heart Association. Circulation. Sep 15 2009;120(11):1011-1020.
190. Jonjev ZS, Bala G. High-energy drinks may provoke aortic dissection. Coll Antropol. May 2013;37 Suppl 2:227-229.
191. Kromann CB, Nielsen CT. A case of cola dependency in a woman with recurrent depression. BMC Res Notes. Dec 21 2012;5:692.
192. Solomin D, Borron SW, Watts SH. STEMI Associated with Overuse of Energy Drinks. Case Rep Emerg Med. 2015;2015:537689.
193. Tofield A. Energy drinks can cause heart problems. Eur Heart J. Mar 1 2015;36(9):537.
194. Usman A, Jawaid A. Hypertension in a young boy: an energy drink effect. BMC Res Notes. Oct 29 2012;5:591.
195. Uwaifo GI. Beware Energy Drinks: A Case of a Toxic Triad Syndrome in a Diabetic Patient With Nonalcoholic Fatty Liver Disease. Am J Med Sci. Oct 2019;358(4):304-311.
196. Belzile D, Cinq-Mars A, Bernier M, et al. Do Energy Drinks Really Give You Wings? Left Ventricular Assist Device Therapy as a Bridge to Recovery for an Energy Drink-Induced Cardiomyopathy. The Canadian journal of cardiology. Feb 2020;36(2):317 e311-317 e313.
197. Chung S, Ha K, Lee HS, et al. Soft drink consumption is positively associated with metabolic syndrome risk factors only in Korean women: Data from the 2007-2011 Korea National Health and Nutrition Examination Survey. Metabolism: clinical and experimental. Nov 2015;64(11):1477-1484.
198. Rebholz CM, Young BA, Katz R, et al. Patterns of Beverages Consumed and Risk of Incident Kidney Disease. Clin J Am Soc Nephrol. Jan 7 2019;14(1):49-56.
199. Stopa M, Lobacz M, Niemczyk M, et al. Influence of energy drinks on acute hemodynamic parameters in young healthy adults: a randomized double-blind placebo-controlled crossover pilot study. Kardiol Pol. Apr 24 2020;78(4):335-337.
200. Ward AE, Lipshultz SE, Fisher SD. Energy drink-induced near-fatal ventricular arrhythmia prevented by an intracardiac defibrillator decades after operative "repair" of tetralogy of Fallot. Am J Cardiol. Oct 1 2014;114(7):1124-1125.
201. Yuzbashian E, Asghari G, Mirmiran P, Zadeh-Vakili A, Azizi F. Sugar-sweetened beverage consumption and risk of incident chronic kidney disease: Tehran lipid and glucose study. Nephrology (Carlton). Jul 2016;21(7):608-616.
202. Zulli A, Smith RM, Kubatka P, et al. Caffeine and cardiovascular diseases: critical review of current research. European journal of nutrition. Jun 2016;55(4):1331-1343.
203. Benjo AM, Pineda AM, Nascimento FO, Zamora C, Lamas GA, Escolar E. Left main coronary artery acute thrombosis related to energy drink intake. Circulation. Mar 20 2012;125(11):1447-1448.
204. Dupasquier E, Bugnon A, Fellay G, Grbic M, Braaker P, Monney A. [Prinzmetal's angor. Apropos of 4 cases. Review of the literature]. Schweiz Med Wochenschr. Sep 27 1975;105(39):1246-1258.
205. Fujii W, Takaki M, Yoshida A, Ishidate H, Ito H, Suga H. Effects of intracoronary caffeine on left ventricular mechanoenergetics in Ca2+ overload failing rat hearts. Jpn J Physiol. Oct 1998;48(5):373-381.
206. Grasser EK, Yepuri G, Dulloo AG, Montani JP. Cardio- and cerebrovascular responses to the energy drink Red Bull in young adults: a randomized cross-over study. European journal of nutrition. Oct 2014;53(7):1561-1571.
207. Lasheras I, Seral P, Alonso-Ventura V, Santabarbara J. The impact of acute energy drink consumption on electrical heart disease: A systematic review and meta-analysis. Journal of electrocardiology. Mar-Apr 2021;65:128-135.
208. Howland J, Rohsenow DJ, Arnedt JT, et al. The acute effects of caffeinated versus non-caffeinated alcoholic beverage on driving performance and attention/reaction time. Addiction. Feb 2011;106(2):335-341.
209. Dikici S, Saritas A, Besir FH, Tasci AH, Kandis H. Do energy drinks cause epileptic seizure and ischemic stroke? The American journal of emergency medicine. Jan 2013;31(1):274 e271-274.
210. Saritas A, Dikici S, Gunes H. Adverse effects of energy drinks. The American journal of emergency medicine. Mar 2015;33(3):461-462.
211. InterAct C, Romaguera D, Norat T, et al. Consumption of sweet beverages and type 2 diabetes incidence in European adults: results from EPIC-InterAct. Diabetologia. Jul 2013;56(7):1520-1530.
212. Kong L, Lu Y, Zhang S, Nan Y, Qiao L. Role of nutrition, gene polymorphism, and gut microbiota in non-alcoholic fatty liver disease. Discovery medicine. Sep 2017;24(131):95-106.
213. Battaglin WA, Bradley PM, Iwanowicz L, Journey CA, Walsh HL, Blazer VS. Pharmaceuticals, hormones, pesticides, and other bioactive contaminants in water, sediment, and tissue from Rocky Mountain National Park, 2012-2013. The Science of the total environment. Dec 1 2018;643:651-673.
214. Furlong ET, Batt AL, Glassmeyer ST, et al. Nationwide reconnaissance of contaminants of emerging concern in source and treated drinking waters of the United States: Pharmaceuticals. The Science of the total environment. Feb 1 2017;579:1629-1642.
215. Ackah M, Anim AK, Zakaria N, et al. Determination of some heavy metal levels in soft drinks on the Ghanaian market using atomic absorption spectrometry method. Environmental monitoring and assessment. Dec 2014;186(12):8499-8507.
216. Gallo P, Di Marco Pisciottano I, Esposito F, et al. Determination of BPA, BPB, BPF, BADGE and BFDGE in canned energy drinks by molecularly imprinted polymer cleaning up and UPLC with fluorescence detection. Food chemistry. Apr 1 2017;220:406-412.
217. Izah SC, Inyang IR, Angaye TCN, Okowa IP. A Review of Heavy Metal Concentration and Potential Health Implications of Beverages Consumed in Nigeria. Toxics. Dec 22 2016;5(1).
218. Kilic S, Cengiz MF, Kilic M. Monitoring of metallic contaminants in energy drinks using ICP-MS. Environmental monitoring and assessment. Mar 9 2018;190(4):202.
219. Shruti VC, Perez-Guevara F, Elizalde-Martinez I, Kutralam-Muniasamy G. First study of its kind on the microplastic contamination of soft drinks, cold tea and energy drinks - Future research and environmental considerations. The Science of the total environment. Jul 15 2020;726:138580.
220. Wuthiekanun V, Amornchai P, Langla S, White NJ, Day NPJ, Limmathurotsakul D. Survival of Burkholderia pseudomallei and Pathogenic Leptospira in Cola, Beer, Energy Drinks, and Sports Drinks. The American journal of tropical medicine and hygiene. Jul 2020;103(1):249-252.
221. Intelligence M. AFRICA ENERGY DRINKS MARKET - GROWTH, TRENDS, COVID-19 IMPACT, AND FORECASTS (2021 - 2026). 2021; https://www.mordorintelligence.com/industry-reports/africa-energy-drink-market.